Patents by Inventor Kambiz Shekdar

Kambiz Shekdar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210380518
    Abstract: Provided herein are compositions and methods of using compositions for treating respiratory diseases in a subject in need of such treatment. In particular, provided herein are compositions and methods of using compositions for the treatment of SARS-CoV-2 (Covid-19). More particularly, provided herein are compositions comprising ENaC agonists for treating SARS-CoV-2 (Covid-19).
    Type: Application
    Filed: June 8, 2021
    Publication date: December 9, 2021
    Inventor: Kambiz Shekdar
  • Publication number: 20200407727
    Abstract: The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.
    Type: Application
    Filed: April 24, 2020
    Publication date: December 31, 2020
    Inventor: Kambiz SHEKDAR
  • Patent number: 10669547
    Abstract: The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 2, 2020
    Inventor: Kambiz Shekdar
  • Patent number: 9872514
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 23, 2018
    Assignee: Chromocell Corporation
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones
  • Publication number: 20170219606
    Abstract: Cells and cell lines that express voltage-gated sodium ion channels (NaV) and methods for using the cells and cell lines are disclosed herein. The NaV-expressing cells and cell lines are useful in cell-based assays, e.g., high throughput screening assays.
    Type: Application
    Filed: January 19, 2016
    Publication date: August 3, 2017
    Inventors: Kambiz Shekdar, Olga Dedova
  • Patent number: 9657357
    Abstract: The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs. The invention relates to methods for making cells comprising one or more reporter nucleic acid constructs using fluorogenic oligonucleotides. The methods relate to high throughput screens.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: May 23, 2017
    Assignee: CHROMOCELL CORPORATION
    Inventors: Kambiz Shekdar, Dennis J. Sawchuk, Jessica C. Langer
  • Publication number: 20170052170
    Abstract: The invention relates to novel cells and cell lines, and methods for making and using them.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 23, 2017
    Inventors: Kambiz Shekdar, Dennis J. Sawchuk, Purvi Manoj Shah
  • Publication number: 20170000178
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Application
    Filed: June 9, 2016
    Publication date: January 5, 2017
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones
  • Patent number: 9534035
    Abstract: Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit combinations and various proteolyzed isoforms of ENaC and techniques for creating cell lines. The ENaC-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results.
    Type: Grant
    Filed: January 25, 2009
    Date of Patent: January 3, 2017
    Assignee: CHROMOCELL CORPORATION
    Inventors: Kambiz Shekdar, Jessica Langer, Dennis Sawchuk
  • Publication number: 20160305970
    Abstract: The invention relates to novel cells and cell lines, and methods for making and using them.
    Type: Application
    Filed: March 22, 2016
    Publication date: October 20, 2016
    Inventor: Kambiz Shekdar
  • Publication number: 20160299127
    Abstract: The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 13, 2016
    Inventors: Kambiz Shekdar, Purvi Manoj Shah, Joseph Gunnet, Jane V. Leland, Peter H. Brown, Louise Slade
  • Publication number: 20160237136
    Abstract: Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit combinations and various proteolyzed isoforms of ENaC and techniques for creating cell lines. The ENaC-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results.
    Type: Application
    Filed: November 19, 2015
    Publication date: August 18, 2016
    Inventors: Kambiz Shekdar, Jessica Langer, Dennis Sawchuk
  • Patent number: 9408407
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 9, 2016
    Assignees: CHROMOCELL CORPORATION, KRAFT FOODS GROUP BRANDS LLC
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones
  • Patent number: 9347934
    Abstract: The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: May 24, 2016
    Assignees: Chromocell Corporation, Kraft Foods Group Brands LLC
    Inventors: Kambiz Shekdar, Purvi Manoj Shah, Joseph Gunnet, Jane V. Leland, Peter H. Brown, Louise Slade
  • Publication number: 20160123959
    Abstract: The present invention relates to methods of isolating cells, generating cell lines, and detecting RNAs in cells using signaling probes that produce a signal upon hybridization to a target sequence. Other methods that utilize the signaling probe include methods of detecting or quantifying the effect of an agent on RNAs in a cell, methods of quantifying the level of RNA expression, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. The invention also provides protease probes. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures are provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 5, 2016
    Inventors: Kambiz Shekdar, Tina Kramer Garyantes, Dennis James Sawchuk
  • Publication number: 20160046948
    Abstract: The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 18, 2016
    Inventor: Kambiz SHEKDAR
  • Publication number: 20150315554
    Abstract: Disclosed herein are cells and cell lines that stably express CFTR and methods for using those cells and cell lines. The invention also includes techniques for creating these cells and cell lines. The cells and cell lines of this invention are physiologically relevant. They are highly sensitive and provide consistent and reliable results in cell-based assays.
    Type: Application
    Filed: November 24, 2014
    Publication date: November 5, 2015
    Inventors: Kambiz Shekdar, Jessica Langer, Srinivasan P. Venkatachalan, Dennis J. Sawchuk
  • Publication number: 20150299782
    Abstract: Methods of isolating cells or generating cell lines comprising the step of exposing the cells to signaling probes that produce a signal upon hybridization to a target sequence, as well as methods of quantifying the level of expression of an RNA of interest, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. Methods for isolating a plurality of cells encoding a plurality of different RNAs associated with a same nucleic acid tag sequence, comprising the step of exposing the cells to a same signaling probe that produces a detectable signal upon hybridization to the same nucleic acid tag sequence, are also provided. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures may be used in the above methods.
    Type: Application
    Filed: November 6, 2014
    Publication date: October 22, 2015
    Inventors: Kambiz Shekdar, Dennis J. Sawchuk, Jason M. Montez
  • Publication number: 20150253339
    Abstract: Cells and cell lines that express voltage-gated sodium ion channels (NaV) and methods for using the cells and cell lines are disclosed herein. The NaV-expressing cells and cell lines are useful in high throughput screening assays.
    Type: Application
    Filed: October 16, 2014
    Publication date: September 10, 2015
    Inventor: Kambiz Shekdar
  • Publication number: 20150237900
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 27, 2015
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones