Patents by Inventor Karel Filka

Karel Filka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4446275
    Abstract: The invention relates to selectively acting polymeric sorbents or saccharides, glycoproteins and saccharide containing polymers. In accordance with the invention, lectins are covalently bonded on vehicles selected from among, oxidized glycosylated hydroxyalkylacrylates or hydroxyalkylmethacrylates, and polyvinyl alcohol. These vehicles are comparable to known materials based on polysaccharides with bonded-on lectins, especially as far as the absorption power of the sorbent is concerned. The preferred process for preparing such sorbents is substantially easier than the hitherto used ones since it does not require specific measures to be taken in the work with highly toxic activating agents, and enables a simple control of conversion degree of the bonding reaction while achieving a relatively high reproducibility. Apart from this, unoxidized saccharide molecules bonded on the vehicle make it hydrophilic, or at least raise its original hydrophility.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: May 1, 1984
    Assignee: Prirodovedecka fakulta University Karlovy
    Inventors: Karel Filka, Jiri Coupek, Jan Kocourek
  • Patent number: 4281233
    Abstract: The invention pertains to hydrophilic macroporous three dimensional copolymers of hydroxyalkyl methacrylates or hydroxyalkyl acrylates (C.sub.1 -C.sub.4 hydroxyalkyl) with crosslinking monomers which contain covalently attached saccharides via an O-glycosidic bond. The invention further pertains to the method of manufacturing of these copolymers by the direct reaction of the basic three dimensional copolymer containing hydroxyl groups with saccharides or their derivatives in an inert organic solvent under catalysis of HCl, BF.sub.3, or their mixtures at 20.degree.-100.degree. C. Saccharides and their derivatives are selected from the group comprising monosaccharides, oligosaccharides, deoxy sugars, amino saccharides, acylated saccharides, ether or halogen derivatives of monosaccharides and oligosaccharides, and the like.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: July 28, 1981
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jiri Coupek, Karel Filka, Jan Kocourek
  • Patent number: 4251634
    Abstract: The invention pertains to hydrophilic macroporous threedimensional copolymers of hydroxyalkyl methacrylates or hydroxyalkyl acrylates (C.sub.1 -C.sub.4 hydroxyalkyl) with crosslinking monomers which contain covalently attached saccharides via an O-glycosidic bond. The invention further pertains to the method of manufacturing of these copolymers by the direct reaction of the basic three dimensional copolymer containing hydroxyl groups with saccharides or their derivatives in an inert organic solvent under catalysis of HCl, BF.sub.3, or their mixtures at 20.degree.-100.degree. C. Saccharides and their derivatives are selected from the group comprising monosaccharides, oligosaccharides, deoxy sugars, amino saccharides, acylated saccharides, ether or halogen derivatives of monosaccharides and oligosaccharides, and the like.
    Type: Grant
    Filed: April 28, 1978
    Date of Patent: February 17, 1981
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jiri Coupek, Karel Filka, Jan Kocourek