Patents by Inventor Karen Auditore-Hargreaves

Karen Auditore-Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoglobulin half-molecules and process for producing hybrid antibodies
    Patent number: 4479895
    Abstract: A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: October 30, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Karen Auditore-Hargreaves
  • Specific binding assay
    Patent number: 4473638
    Abstract: An improvement in a specific binding assay for determining a ligand in a liquid medium, in which assay the labelled conjugate includes FAD and the ligand and in which the labelled conjugate can bind to apoglucose oxidase to form a holoenzyme is provided. The improvement, which renders the assay practical at 37.degree. C., comprises carrying out the assay in the presence of at least about a 250 mM concentration of a polyhydric aldehyde or alcohol, including substrate.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: September 25, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Karen Auditore-Hargreaves
  • Immunoglobulin half-molecules and process for producing hybrid antibodies
    Patent number: 4470925
    Abstract: A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.
    Type: Grant
    Filed: October 4, 1983
    Date of Patent: September 11, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Karen Auditore-Hargreaves
  • Homogeneous immunoassay using covalent hybrid antibodies
    Patent number: 4446233
    Abstract: An immunoassay for analytes such as antigens or haptens, which utilizes covalent hybrid antibodies to modulate the activity of indicators. The hybrid antibody has binding sites for the analyte and the indicator. Final activity of the indicator is proportional to analyte concentration.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: May 1, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Karen Auditore-Hargreaves, Frederick M. Miesowicz