Patents by Inventor Karen Elizabeth Lackey

Karen Elizabeth Lackey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20160339027
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Applicant: NOVARTIS AG
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey, Stephen Barry Guntrip, Kathryn Jane Smith
  • BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20160051551
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Application
    Filed: October 20, 2015
    Publication date: February 25, 2016
    Applicant: NOVARTIS AG
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey, Stephen Barry Guntrip, Kathryn Jane Smith
  • CANCER TREATMENT METHOD
    Publication number: 20150366868
    Abstract: A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 24, 2015
    Applicant: NOVARTIS AG
    Inventors: Karen Elizabeth Lackey, Robert J. Mullin, Neil Spector, Edgar Raymond Wood, III, Wenle Xia
  • Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
    Patent number: 9199973
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: December 1, 2015
    Assignee: Novartis AG
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
  • BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
    Publication number: 20150065527
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Application
    Filed: November 10, 2014
    Publication date: March 5, 2015
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
  • Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
    Patent number: 8912205
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: December 16, 2014
    Assignee: GlaxoSmithKline LLC
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
  • Bicyclic Heteroaromatic Compounds As Protein Tyrosine Kinase Inhibitors
    Publication number: 20130310562
    Abstract: A pharmaceutical formulation comprising the compound of formula
    Type: Application
    Filed: July 16, 2013
    Publication date: November 21, 2013
    Applicant: GlaxoSmithKline LLC
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
  • Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
    Patent number: 8513262
    Abstract: A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L? are suitable leaving groups, with a compound of formula (III) UNH2??(III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L?.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: August 20, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Malcolm Clive Carter, George Stuart Cockerill, Karen Elizabeth Lackey
  • Cancer treatment method
    Patent number: 8444988
    Abstract: A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: May 21, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Karen Elizabeth Lackey, Robert J. Mullin, Neil Spector, Edgar Raymond Wood, III, Wenle Xia
  • CANCER TREATMENT METHOD
    Publication number: 20120058113
    Abstract: A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
    Type: Application
    Filed: November 11, 2011
    Publication date: March 8, 2012
    Inventors: Karen Elizabeth Lackey, Robert J. Mullin, Neil Spector, Edgar Raymond Wood, III, Wenle Xia
  • Cancer Treatment Method
    Publication number: 20110312982
    Abstract: A method of treating cancer is described including administration of a 4-quinazolinamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolinamines.
    Type: Application
    Filed: September 1, 2011
    Publication date: December 22, 2011
    Inventors: Karen Elizabeth Lackey, Robert J. Mullin, Neil Spector, Edgar Raymond Wood, III, Wenle Xia
  • COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20110053934
    Abstract: A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.
    Type: Application
    Filed: January 21, 2010
    Publication date: March 3, 2011
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: RICHARD MARTYN ANGELL, IAN ROBERT BALDWIN, GEORGE STUART COCKERILL, STEPHEN SEAN FLACK, KAREN ELIZABETH LACKEY, PHILIP ALAN SKONE, KATHRYN JANE SMITH
  • Cancer Treatment Method
    Publication number: 20100249160
    Abstract: A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.
    Type: Application
    Filed: June 15, 2010
    Publication date: September 30, 2010
    Inventors: Karen Elizabeth Lackey, Robert J. Mullin, Neil Spector, Edgar Raymond Wood, III, Wenie Xia
  • Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
    Publication number: 20100120804
    Abstract: A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L? are suitable leaving groups, with a compound of formula (III) UNH2 ??(III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L?.
    Type: Application
    Filed: January 22, 2010
    Publication date: May 13, 2010
    Inventors: Malcom Clive Carter, George Stuart Cockerill, Stephen Barry Guntrip, Karen Elizabeth Lackey, Kathryn Jane Smith
  • Heterocyclic compounds
    Patent number: 7507741
    Abstract: Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: March 24, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: George Stuart Cockerill, Karen Elizabeth Lackey
  • Compounds and Methods of Treatment
    Publication number: 20080234267
    Abstract: A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.
    Type: Application
    Filed: March 20, 2007
    Publication date: September 25, 2008
    Inventor: Karen Elizabeth LACKEY
  • Substituted oxindole derivatives as tyrosine kinase inhibitors
    Patent number: 7338966
    Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen Elizabeth Lackey, Edgar Raymond Wood, III
  • Heterocyclic compounds
    Patent number: 7265123
    Abstract: Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: September 4, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: George Stuart Cockerill, Karen Elizabeth Lackey
  • Anilinoquinazaolines as protein tyrosine kianse inhibitors
    Patent number: 7189734
    Abstract: Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein tyrosine kinase inhibition.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: March 13, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: George Stuart Cockerill, Karen Elizabeth Lackey
  • Cancer treatment method
    Patent number: 7141576
    Abstract: A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions containing the same.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: November 28, 2006
    Assignee: SmithKline Beecham (Cork) Limited
    Inventors: Karen Elizabeth Lackey, Neil Spector, Edgar Raymond Wood, III., Wenle Xia