Abstract: The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus pneumoniae. In particular, methods are provided for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines in a subject in need thereof comprising administering to the subject an effective amount of an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide. Immunogenic compositions are also provided comprising one or more pneumococcal polysaccharide antigens and an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide.

Abstract: The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus pneumoniae. In particular, methods are provided for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines in a subject in need thereof comprising administering to the subject an effective amount of an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide. Immunogenic compositions are also provided comprising one or more pneumococcal polysaccharide antigens and an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide.

Abstract: The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP, e.g., to prepare antibodies. Also provided is an anti-IGIP antibody and uses therefor.

Abstract: The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP, e.g., to prepare antibodies. Also provided is an anti-IGIP antibody and uses therefor.

Abstract: The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP.

Abstract: A paddle for use with a defibrillator, the paddle being formed of an applicator attached to a pad portion. The applicator includes a flexible plate, a handle attached to a top of the flexible plate, and an applicator connector disposed on a bottom of the flexible plate. The pad portion is electrically connected to the applicator, and includes a flexible backing that is shaped by the flexible plate, a pad portion connector disposed on the flexible backing to form a connection to the applicator connector, a lid attached to the flexible backing, and an adhesive conductive medium attached to a bottom of the flexible backing and removably encased by the lid. An electrical contact is disposed on the lid and is electrically connected to the pad portion and is exposed while the conductive medium is removably encased by the lid.

Abstract: The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP.

Abstract: An improved trash separator container is provided and consists of a housing having a closed bottom wall and an open top. A first mechanism is within the housing, for dividing the housing into multiple compartments to separately store different types of trash items which are to be recycled therefrom. A top cover fits over the open top of the housing. A second mechanism is in said top cover, for gaining access into each of the compartments so as to deposit the different types of trash items into the compartments. A third mechanism is connected to the closed bottom wall of the housing, for rotating the housing latitudinally along its axis when placed upon a flat surface so that one portion of the access mechanism will always face a person, allowing the person to deposit the trash items into one of the selective compartments.