Patents by Inventor Karen I. Guerin

Karen I. Guerin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-associated virus virions with variant capsids and methods of use thereof
    Patent number: 12031147
    Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: July 9, 2024
    Assignees: The Regents of the University of California, Novartis AG
    Inventors: John G. Flannery, Scott F. Geller, Karen I. Guerin
  • COMPOSITIONS AND METHODS FOR ENHANCING VISUAL FUNCTION
    Publication number: 20230049217
    Abstract: The present disclosure provides compositions and methods of restoring or enhancing visual function in an individual by administering to the individual a pharmaceutical composition comprising a recombinant adeno-associated viral (rAAV) vector having a polynucleotide sequence that encodes a medium wavelength cone opsin (MW-opsin). The MW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.
    Type: Application
    Filed: May 18, 2022
    Publication date: February 16, 2023
    Applicant: Novartis AG
    Inventors: Karen I. Guerin, Robert M. Kotin, Eric Pastor, Xiaozhi Ren, Sharon Young
  • ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSIDS AND METHODS OF USE THEREOF
    Publication number: 20210371879
    Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 2, 2021
    Inventors: John G. Flannery, Scott F. Geller, Karen I. Guerin