Patents by Inventor Karen J. L. Burg
Karen J. L. Burg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10933412Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.Type: GrantFiled: November 27, 2017Date of Patent: March 2, 2021Assignee: University of Georgia Research Foundation, Inc.Inventors: Karen J. L. Burg, Suzanne Tabbaa
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Publication number: 20180078932Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.Type: ApplicationFiled: November 27, 2017Publication date: March 22, 2018Inventors: Karen J.L. Burg, Suzanne Tabbaa
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Patent number: 9849452Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.Type: GrantFiled: November 14, 2014Date of Patent: December 26, 2017Assignee: University of GeorgiaInventors: Karen J. L. Burg, Suzanne Tabbaa
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Publication number: 20150241320Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.Type: ApplicationFiled: November 14, 2014Publication date: August 27, 2015Inventors: Karen J.L. Burg, Suzanne Tabbaa
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Patent number: 8865460Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.Type: GrantFiled: August 11, 2006Date of Patent: October 21, 2014Assignee: Clemson University Research FoundationInventors: David E. Orr, Karen J. L. Burg
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Patent number: 8475531Abstract: Disclosed are osteochondral constructs that can be utilized to encourage both bone and articular cartilage tissue repair in synovial joints. Disclosed constructs are composites including a hydrogel portion for implant in a cartilage defect site and an adjacent portion for implant in a bone defect site. The portion to be implanted in a bone defect site can include a polymeric/ceramic composite material. Disclosed constructs also include a polymeric anchor that can secure the construct at the desired site. Disclosed constructs can also include capillary channeled fibers within the bone portion of the construct that can provide improved nutrient flow to and waste flow from cells growing and developing on and in the construct.Type: GrantFiled: April 20, 2010Date of Patent: July 2, 2013Inventors: Scott A. Maxson, Karen J. L. Burg
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Patent number: 8293531Abstract: Disclosed are three-dimensional (3D) systems as may be utilized for ex vivo tissue or cell growth and development. A system generally includes a base material and at least one wicking fiber embedded therein through which a liquid can be spontaneously drawn by capillary action. Wicking fibers can define a plurality of colinear channels along the exterior surface of the axial length of the fiber. Wicking fibers can be present in disclosed systems as individual fibers or in bundles. Disclosed systems can be useful in various scientific studies, including, but not limited to, drug discovery, vaccine development, cell biology studies, and biomaterial development.Type: GrantFiled: August 29, 2008Date of Patent: October 23, 2012Assignee: Clemson University Research FoundationInventors: Karen J. L. Burg, Chih-Chao Yang
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Publication number: 20090246321Abstract: Disclosed are novel feed supplements for ruminants and methods for making the same. The feed supplements include unsaturated fatty acid encapsulated by a protective coating. Through utilization of the disclosed feed supplements, dietary intake and absorption of unsaturated fatty acids can be increased, due to protection of the ingested unsaturated fatty acids from biohydrogenation in the animal's rumen. The methods of the invention can be utilized to increase unsaturated fatty acid levels in the animal's tissues. Hence, food products obtained from the animal can also have an increased unsaturated fatty acid content and correspondingly lower saturated fatty acid content.Type: ApplicationFiled: June 15, 2009Publication date: October 1, 2009Applicant: CLEMSON UNIVERSITYInventors: Thomas C. Jenkins, Karen J.L. Burg, Steve E. Ellis
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Publication number: 20080293135Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.Type: ApplicationFiled: August 11, 2006Publication date: November 27, 2008Inventors: David E. Orr, Karen J.L. Burg
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Patent number: 7118909Abstract: An apparatus to facilitate precise and efficient evaluation of biomaterials using direct contact cell culture techniques. The apparatus positions the biomaterial and creates the potential to form a fluid-tight seal between the biomaterial and the apparatus, at which point the biomaterial is exposed to cells and/or media. An assay method based on the apparatus is claimed.Type: GrantFiled: May 15, 2002Date of Patent: October 10, 2006Inventors: Matthew R. Gevaert, Karen J. L. Burg
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Patent number: 6991652Abstract: The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.Type: GrantFiled: June 12, 2001Date of Patent: January 31, 2006Inventor: Karen J. L. Burg
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Patent number: 6666893Abstract: A method of reconstructing tissue is provided. The method includes implanting an absorbable tissue expander having a fluid-tight or semipermeable envelope and having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into the chamber and deflatable upon removal of the fluid from the chamber. The tissue expander also has an injection port for the controlled inflation and deflation of the envelope after the device is implanted in a tissue. The method also may include a plurality of envelopes.Type: GrantFiled: March 28, 2001Date of Patent: December 23, 2003Assignee: Charlotte-Mecklenburg HospitalInventors: Karen J. L. Burg, Craig Reed Halberstadt, Walter Dalton Holder, Jr.
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Publication number: 20020182720Abstract: An apparatus to facilitate precise and efficient evaluation of biomaterials using direct contact cell culture techniques. The apparatus positions the biomaterial and creates the potential to form a fluid-tight seal between the biomaterial and the apparatus, at which point the biomaterial is exposed to cells and/or media. An assay method based on the apparatus is claimed.Type: ApplicationFiled: May 15, 2002Publication date: December 5, 2002Inventors: Matthew R. Gevaert, Karen J.L. Burg
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Publication number: 20020022883Abstract: The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.Type: ApplicationFiled: June 12, 2001Publication date: February 21, 2002Inventor: Karen J.L. Burg
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Publication number: 20020010514Abstract: The invention relates to an absorbable implantable tissue expander device that can be used in surgeries as a gradually diminishing space filler. The absorbable tissue expander has a fluid-tight or semipermeable envelope having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into said chamber and deflatable upon removal of the fluid from said chamber. The tissue expander also has a means for the controlled inflation and deflation of the envelope after the device is implanted in a tissue.Type: ApplicationFiled: March 28, 2001Publication date: January 24, 2002Inventors: Karen J.L. Burg, Craig Reed Halberstadt, Walter Dalton Holder
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Patent number: 6206930Abstract: The invention relates to an absorbable implantable tissue expander device that can be used in surgeries as a gradually diminishing space filler. The absorbable tissue expander has a fluid-tight or semipermeable envelope having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into the chamber and deflatable upon removal of the fluid from the chamber. The tissue expander also enables the controlled inflation and deflation of the envelope after the device is implanted in a tissue.Type: GrantFiled: August 10, 1998Date of Patent: March 27, 2001Assignee: Charlotte-Mecklenburg Hospital AuthorityInventors: Karen J. L. Burg, Craig Reed Halberstadt, Walter Dalton Holder, Jr.