Patents by Inventor Karim Dorgham

Karim Dorgham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF THE CX3CRI RECEPTOR AND THERAPEUTIC USES THEREOF
    Publication number: 20120141538
    Abstract: The present invention concerns modulators of the CX3CR1 receptor. More specifically, antagonists and agonists of the CX3CR1 receptor have been identified. These antagonists and agonists can be used for treating an inflammatory disorder, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a graft versus host disease, a behavioral disorder, a cicatrisation disorder, a viral infection, cancer or pain. They may also be used as an adjuvant in a vaccine composition.
    Type: Application
    Filed: December 16, 2009
    Publication date: June 7, 2012
    Applicant: UNIVERSITE PIERRE ET MARIE CURIE -PARIS VI
    Inventors: Guy Gorochov, Karim Dorgham, Christophe Combadiere, Philippe Deterre
  • Methods for construction and screening of libraries of chemokine variants
    Patent number: 7915221
    Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: March 29, 2011
    Assignee: Universite Pierre et Marie Curie (Paris VI)
    Inventors: Guy Gorochov, Oliver Hartley, Karim Dorgham, Patrice Debre, Robin Offord
  • Methods for construction and screening of libraries of chemokine variants
    Publication number: 20090075874
    Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
    Type: Application
    Filed: April 2, 2007
    Publication date: March 19, 2009
    Inventors: Guy Gorochov, Oliver Hartley, Karim Dorgham, Patrice Debre, Robin Offord
  • Methods and construction and screening of libraries of chemokine variants
    Patent number: 7211564
    Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: May 1, 2007
    Assignees: Universite Pierre et Marie Curie (ParisVI), Universite De Geneve
    Inventors: Guy Gorochov, Oliver Hartley, Karim Dorgham, Patrice Debre, Robin Offord
  • Methods and construction and screening of libraries of chemokine variants
    Publication number: 20040258659
    Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
    Type: Application
    Filed: March 4, 2004
    Publication date: December 23, 2004
    Inventors: Guy Gorochov, Oliver Hartley, Karim Dorgham, Patrice Debre, Robin Offord
  • Methods for construction and screening of libraries of chemokine variants
    Publication number: 20030049603
    Abstract: The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral deseases.
    Type: Application
    Filed: September 5, 2001
    Publication date: March 13, 2003
    Inventors: Guy Gorochov, Oliver Hartley, Karim Dorgham, Patrice Debre, Robin E. Offord