Patents by Inventor Karin D. Caldwell

Karin D. Caldwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7858108
    Abstract: Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled conditions.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: December 28, 2010
    Inventors: Jennifer A. Neff, Karin D. Caldwell, Jonas Andersson, Bo Nilsson, Kristina Nilsson-Ekdahl
  • Patent number: 7645721
    Abstract: A method for coimmobilizing two or more biomolecules on a substrate in a defined ratio is disclosed. The method uses a copolymer conjugated to a number, N, of different types of oligonucleotides. The copolymer can be adsorbed to the surface of the substrate. N types of oligonucleotides complementary to the copolymer-bound oligonucleotides can be conjugated to N types of biomolecules. The types of the copolymer-bound oligonucleotides can be mixed in a defined ratio then adsorbed to the surface. The biomolecule-bound complementary oligonucletides can be conjugated to the copolymer-oligonucleotides to create a substrate with the biomolecules coimmobilized in a defined ratio. The invention also relates to a substrate prepared by the method of the invention.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: January 12, 2010
    Inventors: Karin D. Caldwell, Jennifer A. Neff
  • Patent number: 7208299
    Abstract: The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecule conjugated EGAP can be put to numerous uses including cell adhesion, cell growth, cell sorting, and other biological assays.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: April 24, 2007
    Assignee: Universtiy of Utah Research Foundation
    Inventors: Karin D. Caldwell, Patrick A. Tresco, Jennifer Neff
  • Patent number: 7022515
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: April 4, 2006
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Karin D. Caldwell, Vera Janatov√°, Shao-Chie Huang, Hsu-Kun Wang
  • Publication number: 20040170964
    Abstract: The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecule conjugated EGAP can be put to numerous uses including cell adhesion, cell growth, cell sorting, and other biological assays.
    Type: Application
    Filed: December 30, 2003
    Publication date: September 2, 2004
    Inventors: Karin D. Caldwell, Patrick A. Tresco, Jennifer Neff
  • Patent number: 6670199
    Abstract: The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecule conjugated EGAP can be put to numerous uses including cell adhesion, cell growth, cell sorting, and other biological assays.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: December 30, 2003
    Assignee: University of Utah Research Foundation
    Inventors: Karin D. Caldwell, Patrick A. Tresco, Jennifer Neff
  • Publication number: 20020160534
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
    Type: Application
    Filed: October 5, 2001
    Publication date: October 31, 2002
    Inventors: James N. Herron, Douglas A. Christensen, Karin D. Caldwell, Vera Janatova, Shao-Chie Huang, Hsu-Kun Wang
  • Publication number: 20020019037
    Abstract: The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecule conjugated EGAP can be put to numerous uses including cell adhesion, cell growth, cell sorting, and other biological assays.
    Type: Application
    Filed: September 4, 2001
    Publication date: February 14, 2002
    Inventors: Karin D. Caldwell, Patrick A. Tresco, Jennifer Neff
  • Patent number: 6340598
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: January 22, 2002
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Karin D. Caldwell, Vera Janatov√°, Shao-Chie Huang, Hsu-Kun Wang
  • Patent number: 6284503
    Abstract: The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (FGAP). The biomolecule conjugated EGAP can be put to numerous uses including cell adhesion, cell growth, cell sorting, and other biological assays.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: September 4, 2001
    Assignee: University of Utah Research Foundation
    Inventors: Karin D. Caldwell, Patrick A. Tresco, Jennifer Neff
  • Patent number: 6136171
    Abstract: A micromachined system for electrical field-flow fractionation of small test fluid samples is provided. The system includes a microchannel device comprising a first substrate having a planar inner surface with an electrode formed thereon. A second substrate having a planar inner surface with an electrode formed thereon is positioned over the first substrate so that the respective electrodes face each other. An insulating intermediate layer is interposed between the first and second substrates. The intermediate layer is patterned to form opposing sidewalls of at least one microchannel, with the electrodes on the substrates defining opposing continuous boundaries along the length of the microchannel. Inlet and outlet ports are formed in one or both substrates for allowing fluid flow into and out of the microchannel. The microchannel device can be fabricated with single or multiple microchannels therein for processing single or multiple test fluids.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: October 24, 2000
    Assignee: The University of Utah Research Foundation
    Inventors: A. Bruno Frazier, Karin D. Caldwell, Bruce K. Gale
  • Patent number: 6087452
    Abstract: A modified surfactant of the PLURONIC.TM.-type compound and method for manufacture is disclosed. The surfactant compound has at least one PEO block attached at a first end to at least one PPO block, with at least one of the PEO block having an organic metal-chelating end group (R) attached to a second end, the remaining PEO blocks having an unmodified hydroxyl group at the second end. The metal-chelating group is charged with an metal-ion. A protein with a metal-affinity tag, e.g., a histidine tag, is then complexed with the metal-chelating group to form a complex of the modified surfactant, the metal ion, and the protein. The modified surfactant may be adsorbed upon a hydrophobic surface, charged with a metal ion, and then complexed with a protein with a metal-affinity tag. A surface with specific activity toward proteins is the presented, which is suitable for applications where a protein is immobilized upon a surface to give the surface specific protein activity.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: July 11, 2000
    Assignee: University of Utah
    Inventors: Russell Stewart, Karin D. Caldwell, Chih-hu Ho, Loren Limberis
  • Patent number: 5919712
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A preferred embodiment of the biosensor and assay method have patches of capture molecules each specific for a different analyte disposed adjacent within a single reservoir. The capture molecules are immobilized to the patches on the waveguide surface by site-specific coupling of thiol groups on the capture molecules to photo-affinity crosslinkers which in turn are coupled to the waveguide surface or to a non-specific-binding-resistant coating on the surface. The patches of different antibodies are produced by selectively irradiating a portion of the waveguide surface during the process of coupling the photo-affinity crosslinkers the selective irradiation involving a mask, a laser light source, or the like.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: July 6, 1999
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Hsu-Kun Wang, Karin D. Caldwell, Vera Janatova, Shao-Chie Huang
  • Patent number: 5846842
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: December 8, 1998
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Karin D. Caldwell, Vera Janatova, Shao-Chie Huang, Hsu-Kun Wang
  • Patent number: 5677196
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A preferred embodiment of the biosensor and assay method have patches of capture molecules each specific for a different analyte disposed adjacent within a single reservoir. The capture molecules are immobilized to the patches on the waveguide surface by site-specific coupling of thiol groups on the capture molecules to photo-affinity crosslinkers which in turn are coupled to the waveguide surface or to a non-specific-binding-resistant coating on the surface. The patches of different antibodies are produced by selectively irradiating a portion of the waveguide surface during the process of coupling the photo-affinity crosslinkers the selective irradiation involving a mask, a laser light source, or the like.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: October 14, 1997
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Hsu-Kun Wang, Karin D. Caldwell, Vera Janatova, Shao-Chie Huang
  • Patent number: 5512492
    Abstract: Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: April 30, 1996
    Assignee: University of Utah Research Foundation
    Inventors: James N. Herron, Douglas A. Christensen, Karin D. Caldwell, Vera Janatova, Shao-Chie Huang, Hsu-Kun Wang
  • Patent number: 5240618
    Abstract: Improved apparatus and procedures for electrical field-flow fractionation is disclosed. A test sample is injected into the liquid carrier stream flowing through the flow channel of the apparatus. The apparatus comprises a thin flow channel having a top, a bottom, and two side walls, with a fluid carrier inlet at one end and an outlet at the other end. The top and bottom walls are formed such that at least the inner surfaces thereof that face the flow channel are made of an electrically conductive material so that the inner surfaces thereof form electrodes as well as opposite, broad boundary surfaces of the flow channel. A voltage differential is applied to the electrically conductive inner surfaces of the top and bottom walls. The carrier fluid flowing through the channel can be deionized or distilled water as well as water containing a red-ox couple such as quinone/hydroquinone.
    Type: Grant
    Filed: February 3, 1992
    Date of Patent: August 31, 1993
    Assignee: University of Utah Research Foundation
    Inventors: Karin D. Caldwell, Yu-Shu Gao
  • Patent number: 5112736
    Abstract: A method for the multiplex sequencing on DNA is disclosed which comprises the electroblotting or specific base terminated DNA fragments, which have been resolved by gel electrophoresis, onto the surface of a neutral non-aromatic polymeric microporous membrane exhibiting low background fluorescence which has been surface modified to contain amino groups. Polypropylene membranes are preferably and the introduction of amino groups is accomplished by subjecting the membrane to radio or microwave frequency plasma discharge in the presence of an aminating agent, preferably ammonia. The membrane, containing physically adsorbed DNA fragments on its surface after the electroblotting, is then treated with crosslinking means such as UV radiation or a glutaraldehyde spray to chemically bind the DNA fragments to the membrane through said smino groups contained on the surface thereof.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: May 12, 1992
    Assignees: University of Utah, Brigham Young University
    Inventors: Karin D. Caldwell, Tun-Jen Chu, William G. Pitt