Patents by Inventor Karin G. Au

Karin G. Au has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 6008031
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: December 28, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Solutions containing mismatch repair system proteins mutL and mutS
    Patent number: 5861482
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 19, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 5858754
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: January 12, 1999
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulating of DNA utilizing mismatch repair systems
    Patent number: 5702894
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 30, 1997
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods of analysis and manipulation of DNA utilizing mismatch repair systems
    Patent number: 5679522
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 21, 1997
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
  • Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
    Patent number: 5556750
    Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: September 17, 1996
    Assignee: Duke University
    Inventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani L. Cooper, Leroy Worth, Jr.
  • Methods for mapping genetic mutations
    Patent number: 5459039
    Abstract: The present invention relates to a method for detecting base sequence differences within homologous regions of two DNA molecules comprising the steps of contacting at least one strand of the first DNA molecule with the complementary strand of the second DNA molecule under conditions such that base pairing occurs, contacting the resulting DNA duplexes with a protein that recognizes substantially all base pair mismatches under conditions such that the protein forms specific complexes with its cognate mispairs, and detecting the resulting DNA:protein complexes by a suitable analytical method. Also disclosed are protein components of DNA mismatch correction systems and the use of these components in methods for genetic mapping.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: October 17, 1995
    Assignee: Duke University
    Inventors: Paul Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue