Patents by Inventor Karine Fabienne Malagu

Karine Fabienne Malagu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-fused thiophene derivatives and their uses
    Patent number: 11840527
    Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: December 12, 2023
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoît De Chassey, Peter Machin, Karine Fabienne Malagu, Paul Colin Michael Winship, Mark Chambers, Jamie David Knight, Roberta Lanaro
  • HTT modulators for treating Huntington's disease
    Patent number: 11806346
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: November 7, 2023
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Elizabeth M. Doherty, Longbin Liu, Matthew Lee, Mark Stuart Chambers, Karine Fabienne Malagu, Perla Breccia, Alan F. Haughan, Huw D. Vater, Andrew J. Stott, William R. K. Esmieu, Stephen John Webster, Amanda J. Van De Poël
  • Thiophene derivatives as antiviral agents
    Patent number: 11807618
    Abstract: The present invention relates to a new class of compounds having an antiviral effect and the uses thereof.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: November 7, 2023
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoît De Chassey, Laëtitia Lines, Jérôme Amaudrut, Benaissa Boubia, Vincent Derain, Fabrice Guillier, Christian Montalbetti, Calum Macleod, Karine Fabienne Malagu, David Robert Vesey, Paul Colin Michael Winship
  • Non-fused thiophene derivatives and their uses
    Patent number: 11767316
    Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: September 26, 2023
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoît De Chassey, Peter Machin, Karine Fabienne Malagu, Paul Colin Michael Winship, Jean-Laurent Paparin, Mark Chambers, Jamie David Knight, Roberta Lanaro
  • Fused thiophene derivatives and their uses
    Patent number: 11603368
    Abstract: The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: March 14, 2023
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoît De Chassey, Peter Machin, Roberta Lanaro, Calum Macleod, Karine Fabienne Malagu, Nicolas Proisy, David Robert Vesey, Paul Colin Michael Winship, Mark Chambers, Jean-Laurent Paparin
  • HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20220409615
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 29, 2022
    Inventors: Celia Dominguez, Elizabeth M. Doherty, Longbin Liu, Matthew Lee, Mark Stuart Chambers, Karine Fabienne Malagu, Perla Breccia, Alan F. Haughan, Huw D. Vater, Andrew J. Stott, William R. K. Esmieu, Stephen John Webster, Amanda J. Van De Poël
  • Fused thiophene derivatives and their uses
    Patent number: 11492347
    Abstract: The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: November 8, 2022
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoît De Chassey, Peter Machin, Roberta Lanaro, Calum MacLeod, Karine Fabienne Malagu, Nicolas Proisy, David Robert Vesey, Paul Colin Michael Winship, Mark Chambers
  • THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS
    Publication number: 20220213053
    Abstract: The present invention relates to a new class of compounds having an antiviral effect and the uses thereof.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 7, 2022
    Inventors: ERIC MELDRUM, BENOÎT DE CHASSEY, LAËTITIA LINES, JÉRÔME AMAUDRUT, BENAISSA BOUBIA, VINCENT DERAIN, FABRICE GUILLIER, CHRISTIAN MONTALBETTI, CALUM MACLEOD, KARINE FABIENNE MALAGU, DAVID ROBERT VESEY, PAUL COLIN MICHAEL WINSHIP
  • Thiophene derivatives as antiviral agents
    Patent number: 11279683
    Abstract: The present invention relates to a new class of compounds of formula (I) having an antiviral effect and the uses thereof.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: March 22, 2022
    Assignee: ENYO PHARMA
    Inventors: Eric Meldrum, Benoit De Chassey, Laetitia Lines, Jerome Amaudrut, Benaissa Boubia, Vincent Derain, Fabrice Guillier, Christian Montalbetti, Calum MacLeod, Karine Fabienne Malagu, David Robert Vesey, Paul Colin Michael Winship
  • Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
    Publication number: 20210238159
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Application
    Filed: April 15, 2021
    Publication date: August 5, 2021
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
    Patent number: 10988454
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: April 27, 2021
    Assignees: AbbVie Overseas S.à.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
    Patent number: 10981890
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: April 20, 2021
    Assignees: AbbVie Overseas S.à.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES
    Publication number: 20210040059
    Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Application
    Filed: February 8, 2019
    Publication date: February 11, 2021
    Inventors: ERIC MELDRUM, BENOÎT DE CHASSEY, PETER MACHIN, KARINE FABIENNE MALAGU, PAUL COLIN MICHAEL WINSHIP, JEAN-LAURENT PAPARIN, MARK CHAMBERS, JAMIE DAVID KNIGHT, ROBERTA LANARO
  • NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES
    Publication number: 20200369655
    Abstract: The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Application
    Filed: February 8, 2019
    Publication date: November 26, 2020
    Inventors: ERIC MELDRUM, BENOÎT DE CHASSEY, PETER MACHIN, KARINE FABIENNE MALAGU, PAUL COLIN MICHAEL WINSHIP, MARK CHAMBERS, JAMIE DAVID KNIGHT, ROBERTA LANARO
  • FUSED THIOPHENE DERIVATIVES AND THEIR USES
    Publication number: 20200369682
    Abstract: The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Application
    Filed: February 8, 2019
    Publication date: November 26, 2020
    Inventors: ERIC MELDRUM, BENOÎT DE CHASSEY, PETER MACHIN, ROBERTA LANARO, CALUM MACLEOD, KARINE FABIENNE MALAGU, NICOLAS PROISY, DAVID RICHARD VESEY, PAUL COLIN MICHAEL WINSHIP, MARK CHAMBERS, JEAN-LAURENT PAPARIN
  • Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
    Patent number: 10844041
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: November 24, 2020
    Assignees: AbbVie Overseas S.à.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
    Patent number: 10844042
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: November 24, 2020
    Assignees: AbbVie Overseas S.à.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • FUSED THIOPHENE DERIVATIVES AND THEIR USES
    Publication number: 20200361924
    Abstract: The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
    Type: Application
    Filed: February 8, 2019
    Publication date: November 19, 2020
    Inventors: ERIC MELDRUM, BENOÎT DE CHASSEY, PETER MACHIN, ROBERTA LANARO, CALUM MACLEOD, KARINE FABIENNE MALAGU, NICOLAS PROISY, DAVID RICHARD VESEY, PAUL COLIN MICHAEL WINSHIP, MARK CHAMBERS
  • Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
    Patent number: 10829473
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: November 10, 2020
    Assignees: AbbVie Overseas S.à.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung
  • MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
    Publication number: 20200277275
    Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 3, 2020
    Inventors: Robert J. Altenbach, Andrew Bogdan, Sylvain Couty, Nicolas Desroy, Gregory A. Gfesser, Christopher Gaëtan Housseman, Philip R. Kym, Bo Liu, Thi Thu Trang Mai, Karine Fabienne Malagu, Nuria Merayo Merayo, Olivier Laurent Picolet, Mathieu Rafaël Pizzonero, Xenia B. Searle, Steven Emiel Van der Plas, Xueqing Wang, Ming C. Yeung