Patents by Inventor Karl F. Mueller

Karl F. Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4983702
    Abstract: A contact lens is described which is synthesized by reaction in a mold of a isocyanate capped poly(dialkylsiloxane) prepolymer with a poly(dialkylsiloxane) di- or polyalkanol. The clear polyurethane rubber contact lens is readily made completely wettable by a transfer-grafting process or post-treatment and has a high oxygen permeability.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: January 8, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Paul Harisiades
  • Patent number: 4954587
    Abstract: This invention describes polymers which are obtained by copolymerization of 15-85 wt % N,N-dimethylacrylamide with about 15-85% of a fluorinated monomer such as perfluoroalkyl-alkylene acrylate or methacrylate with from 3 to 25 fluorine atoms and optionally, 0-50 wt % other acrylates or methacrylates and 0-20 wt %, but not more than 5 mol % of a polyvinyl functional crosslinking agent. These polymers are machinable in the dry state and form clear hydrogels with about 25-75 wt % water content and which possess oxygen-permeabilities 3-7 times higher than conventional hydrogels of similar water content. In the absence of crosslinking, the novel polymers are plasticized by water, forming clear hydroplastics with 30-70 wt % water content. The crosslinked polymers are especially useful for fabricating contact lenses for extended wear by either cutting and polishing a xerogel button, or by spin casting or direct molding in bulk or in solution.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: September 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Karl F. Mueller
  • Patent number: 4923906
    Abstract: New polysiloxane contact lenses are described which are prepared from polysiloxanes bearing at least three polymerizable vinyl groups by copolymerization with acrylic comonomers. The new lens materials are characterized by a superior combination of high oxygen permeability and rigidity.
    Type: Grant
    Filed: April 26, 1989
    Date of Patent: May 8, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Paul Harisiades
  • Patent number: 4837289
    Abstract: New polysiloxanes are described which bear at least three vinyl groups. Such polyvinyl polysiloxanes are useful as heat or UV curing resins with high cross link density and are especially useful as coatings and in the manufacture of contact lens materials.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: June 6, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Paul Harisiades
  • Patent number: 4734475
    Abstract: A contact lens possessing a wettable surface in its aqueous environment of use fabricated from a hydrophobic addition polymer incorporating between about 0.5 and about 30% weight oxirane substituted units in the backbone thereof, wherein the outer surfaces of said lens contain an effective hydrophilic inducing amount of a reaction product of said oxirane substituted units of the formula ##STR1## wherein R is hydrogen or methyl;R.sub.1 is ##STR2## or lower alkylene; n is 1 to 4; andR.sub.0 is hydrogen or ##STR3## with a water soluble reactive organic amine, alcohol, thiol, urea or thiourea or a sulfite, bisulfite or thiosulfate, and the use thereof by placement in the eye of a patient in need of the same to correct vision defects of a refractive nature.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: March 29, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Merrill Goldenberg, Karl F. Mueller
  • Patent number: 4720187
    Abstract: Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also --COOR.sub.5 where R.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: January 19, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Merrill Goldenberg, Karl F. Mueller
  • Patent number: 4670506
    Abstract: Organic aprotic solvent soluble polymers which are derivatives of a polyvinyl alcohol, having a weight average molecular weight of at least about 2,000, and containing from about 0.5 to about 90 percent, based on the number of hydroxyl groups in said polyvinyl alcohol, of units of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkylene, arylene, cycloaliphatic, aralkylene or aralkarylene, n is 0 or 1, A.sub.1 is a carbamoyloxy or ureido linking group, A is an oxa, imino or ureido group, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, or when R.sub.3 is hydrogen, methyl or also -COOR.sub.5 where B.sub.5 is hydrogen or lower alkyl, and crosslinked hydrogel contact lenses made therefrom and their preparation.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: June 2, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Merrill Goldenberg, Karl F. Mueller
  • Patent number: 4619974
    Abstract: Perfluoroalkyl alkylene substituted polydienes are described which are obtained by addition of perfluoroalkyl-alkylene thiols to polydienes and which are useful as hard, oil- and water repellent coatings on metal, paper, wood, glass ceramics, textiles or leather.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: October 28, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Karl F. Mueller
  • Patent number: 4605712
    Abstract: Polysiloxanes of uniform molecular weight (MW) distribution with 500-10,000 MW segments of polysiloxane and containing at least one vinyl group connected to said polysiloxane segments through intervening alkylene-urea or -urethane linkages are prepared from polysiloxane-polyols, -polyamines or -polythiols by reaction with an unsaturated compound containing an isocyanato moiety, for example 2-isocyanatoethyl methacrylate. The polysiloxanes containing the vinyl groups are useful as radiation- or thermally curable coatings for glass, textiles, plastics, wood, ceramics, metals, as films or bandages for medicinal purposes, or molded shapes, in form of contact lenses, catheters or implants, either by themselves or in combination with other vinyl monomers; and are particularly useful in preparing hard or soft contact lenses, including hydrogel contact lenses.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: August 12, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Dieter Lohmann, Robert A. Falk
  • Patent number: 4590129
    Abstract: Fluoroaliphatic-thio,-sulfinyl and -sulfonyl substituted bicycloaliphatic amic acid amine salts of the formula ##STR1## where R.sub.f is perfluoroalkyl, R' is alkylene optionally interrupted by --O--, --S-- or ##STR2## where R.sub.a is hydrogen or alkyl, Y is lower alkylene or --O--, n is 0-2, R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, hydroxy lower alkyl or together with the nitrogen to which they are attached, represent morpholino, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or hydroxy lower alkyl, R.sub.6 is lower alkyl, carboxy lower alkyl, sulfo lower alkyl, hydroxy lower alkyl, benzyl or together with R.sub.5 and the nitrogen to which they are attached represent morpholino, and R is hydrogen or methyl are provided. These salts applied in the form of aqueous solutions, dispersions or emulsions are useful in rendering cellulosic and natural and synthetic polyamide materials oil and water repellent.
    Type: Grant
    Filed: January 17, 1985
    Date of Patent: May 20, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Jurgen Kaschig, Eduard K. Kleiner, Karl F. Mueller, Thomas W. Cooke
  • Patent number: 4548990
    Abstract: A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: October 22, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber
  • Patent number: 4515640
    Abstract: Fluoroaliphatic-thio,-sulfinyl and -sulfonyl substituted bicycloaliphatic amic acid amine salts of the formula: ##STR1## where R.sub.f is perfluoroalkyl, R' is alkylene optionally interrupted by --O--, --S-- or ##STR2## where R.sub.a is hydrogen or alkyl, Y is lower alkylene or --O--, n is 0-2, R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, hydroxy lower alkyl or together with the nitrogen to which they are attached, represented morpholino, R.sub.3, R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or hydroxy lower alkyl, R.sub.6 is lower alkyl, carboxy lower alkyl, sulfo lower alkyl, hydroxy lower alkyl, benzyl or together with R.sub.5 and the nitrogen to which they are attached represent morpholino, and R is hydrogen or methyl are provided. These salts applied in the form of aqueous solutions, dispersions or emulsions are useful in rendering cellulosic and natural and synthetic polyamide materials oil and water repellent.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: May 7, 1985
    Assignee: Ciba Geigy Corporation
    Inventors: Jurgen Kaschig, Eduard K. Kleiner, Karl F. Mueller, Thomas W. Cooke
  • Patent number: 4486577
    Abstract: Clear, strong, crosslinked polymers are described, which are obtained by copolymerization of (A) 8-70% of a linear or branched polysiloxane of 400-100,000 molecular weight (MW) containing at least two terminal or pendant, polymerizable, vinyl groups per each 5000 MW unit of polysiloxane and which are attached to the polysiloxane through at least two urethane, thiourethane, urea or amide linkages and (B) 30-92% of a mono- or divinyl compound or a mixture of such monomers consisting of 85 to 100% of water insoluble monomers. These polymers are useful in the preparation of hard or soft contact lenses.
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: December 4, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber, Walter L. Plankl
  • Patent number: 4423099
    Abstract: Non-uniform water-insoluble interpenetrating polymer blend compositions comprising a first permeable water swellable polymer substrate interpenetrated in a gradient substantially normal to the substrate surface by a second less permeable condensation polymer to form a diffusion rate controlling membrane therein. Such compositions are useful as polymers with reduced permeabilities for water and organic solvents and therefore for the controlled delivery of active ingredients such as fragrances and bio-affecting agents into air or aqueous environments, or in membrane separation processes.
    Type: Grant
    Filed: July 28, 1980
    Date of Patent: December 27, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber
  • Patent number: 4304591
    Abstract: A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different watersoluble mono-olefinic monomers, or (b) copolymer of said watersoluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000 is disclosed. The gel is suitable for use as a carrier for medicaments and pesticides.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: December 8, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, William R. Good
  • Patent number: 4277582
    Abstract: A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different watersoluble mono-olefinic monomers, or (b) copolymer of said watersoluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: July 7, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, William R. Good
  • Patent number: 4267087
    Abstract: This invention describes new perfluoroalkyl substituted esters, diesters and polyesters which contain at least one cyclic 5-membered anhydride group or two carboxy groups, as well as half amides and half esters thereof; their synthesis and their use as surface-active reactants in polycondensate resin systems.The anhydrides are synthesized by reaction of perfluoroalkyl substituted alcohols or diols with dianhydrides or an anhydrides-acid chloride and have the general structure ##STR1## wherein: Q is the tetra-radical rest of a tri- or tetra-carboxylic acid, which contains at least one 1,2-dicarboxy grouping,X is hydrogen or COOH,R.sub.f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group of 4 to 18 carbon atoms,a is 1 or 2,A is hydrogen or ##STR2## wherein: m is an integer from 0 to 5, andR.sup.3 is the residue of a R.sub.f substituted alcohol or diol.
    Type: Grant
    Filed: February 16, 1979
    Date of Patent: May 12, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Karl F. Mueller
  • Patent number: 4266080
    Abstract: Perfluoroalkyl compounds containing ether groups have the formulaR.sub.f R.sub.1 SCH.sub.2 CH.sub.2 O T Zwherein R.sub.f is a perfluoroalkyl, R.sub.1 is alkylene or alkyleneoxy or aminoalkylene, T is alkylene, and Z is hydrogen; hydroxy; NR.sub.3 R.sub.4, where R.sub.3 and R.sub.4 each is alkyl or together with nitrogen form a heterocyclic ring; N.sup.+ R.sub.3 R.sub.4 (R.sub.5)X.sub.z.sup.-y, where R.sub.5 is hydrogen, oxide, alkyl, or substituted alkyl, X is an anion, and y is 1 or 2; z is 0 or 1 or is --OCH.sub.2 CH.sub.2 SR.sub.1 R.sub.f ; can be prepared directly by free-radical catalyzed addition of a perfluoroalkylthiol to a vinyl ether or subsequent reaction. These compounds are useful as surfactants and oil spill collecting agents.
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: May 5, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Robert A. Falk, Karl F. Mueller
  • Patent number: 4242516
    Abstract: The invention is directed to fluorinated compounds of the formula ##STR1## wherein R.sub.f is a perfluoroalkyl or perfluoroalkoxyperfluoroalkyl group, R.sup.1 is a branched or straight chain alkylene, alkylenethioalkylene, alkyleneoxyalkylene or alkyleneiminoalkylene group, X is oxygen or an amino group, Q is an organic group containing at least one amino group and y is zero or 1, and the corresponding succinimides. These compounds are useful as surfactants.
    Type: Grant
    Filed: January 12, 1978
    Date of Patent: December 30, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Karl F. Mueller
  • Patent number: 4224427
    Abstract: The disclosure describes an improved process for the preparation of uniform, spherical beads of up to 5 mm diameter of a crosslinked, water-insoluble hydrogel by suspension polymerization in a concentrated aqueous salt solution of 95-30% by weight of a monoolefinic water-soluble monomer containing at least 5% of a hydroxy substituted hydrophilic vinyl monomer with 5-70% by weight of a terminal diolefinic macromer crosslinking agent in the presence of water-insoluble, gelatinous, strong water-bonding inorganic metal hydroxides as suspending agents in the absence of excess alkali. The hydrogels have a host of pharmaceutical and industrial uses.
    Type: Grant
    Filed: June 1, 1978
    Date of Patent: September 23, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl F. Mueller, Sonia J. Heiber, Walter L. Plankl