Abstract: A process for the cyclic control of extruders which facilitates the precise control of an extruder to achieve maximum output and at the same time optimal quality of the extruded profiles. Accordingly therefore the extrusion velocity is controlled in such a way that the profile exit temperature is constant and equal to a prescribed temperature trajectory. Thereby the extrusion velocity and the profile exit temperature are measured over the complete cycle interval for each and every cycle k, and with the knowledge of the relationship between these quantities and the trajectory of the extrusion velocity of the cycle k, the trajectory of the extrusion velocity for the (k+1)th cycle is determined, such that the control error and the control effort are as low as possible and after completion of the (k+1)th extrusion cycle the whole process is repeated for every subsequent cycle therefore until the whole extrusion program is completed.

Abstract: Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufaccure of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorders and/or coadministration with another active agent to increase the bioavailability thereof, or for nasal administration.

Abstract: Use of a mono or dicyclic carboxylic or heterocyclic carboxylic acid ester or amide of an alcohol or amine nitrogen as a ring atom in free base form or in acid addition or quaternary ammonium salt form as a 5-HT.sub.3 antagonist in the manufacture of a medicament suitable for the treatment of serotonin induced gastrointestinal disturbances.