Patents by Inventor Karl Heinz Drexhage

Karl Heinz Drexhage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190322870
    Abstract: The invention relates to compounds of the general formulae (I)-(IV), which are characterized by substituents B comprising one or more sulfonic acid groups and their use as marker groups for the detection of analytes.
    Type: Application
    Filed: September 28, 2018
    Publication date: October 24, 2019
    Applicant: ATTO-TEC GmbH
    Inventors: Norbert Kemnitzer, Alexander Zilles, Karl-Heinz Drexhage, Monika Hamers-Schneider, Jutta Arden-Jacob
  • Publication number: 20190100653
    Abstract: The invention relates to compounds of the general formulae (I)-(IV), which are characterized by substituents B comprising one or more sulfonic acid groups and their use as marker groups for the detection of analytes.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 4, 2019
    Inventors: Norbert Kemnitzer, Alexander Zilles, Karl-Heinz Drexhage, Monika Hamers-Schneider, Jutta Arden-Jacob
  • Patent number: 9651490
    Abstract: The present invention relates to polycyclic compounds of the general formula (I) which are distinguished by an amine substituent NR6R7 on the central carbon atom of the chromophore, to processes for their preparation, and to the use thereof for the determination of analytes.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: May 16, 2017
    Assignee: ATTO-TEC GMBH
    Inventors: Alexander Zilles, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Jutta Arden-Jacob, Monika Hamers-Schneider
  • Patent number: 9035042
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: May 19, 2015
    Assignee: ATTO-TEC GmbH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Monika Hamers-Schneider
  • Patent number: 8846924
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: September 30, 2014
    Assignee: Atto-Tec GmbH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Monika Hamers-Schneider
  • Patent number: 8785637
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: July 22, 2014
    Assignee: Atto-Tec GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Patent number: 8614317
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: December 24, 2013
    Assignee: Atto-Tec GmbH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Monika Hamers-Schneider
  • Publication number: 20130323851
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Patent number: 8530660
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 10, 2013
    Assignee: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Publication number: 20130224871
    Abstract: The present invention relates to polycyclic compounds of the general formula (I) which are distinguished by an amine substituent NR6R7 on the central carbon atom of the chromophore, to processes for their preparation, and to the use thereof for the determination of analytes.
    Type: Application
    Filed: October 18, 2011
    Publication date: August 29, 2013
    Applicant: ATTO-TEC GmbH
    Inventors: Alexander Zilles, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Jutta Arden-Jacob, Monika Hamers-Schneider
  • Publication number: 20110223677
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 15, 2011
    Applicant: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Këmnitzer, Alexander Zilles
  • Publication number: 20110190486
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 4, 2011
    Applicant: ATTO-TEC GMBH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Monika Hamers-Schneider
  • Publication number: 20110172420
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Application
    Filed: March 25, 2011
    Publication date: July 14, 2011
    Applicant: ATTO-TEC GMBH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Uwe Kemnitzer, Monika Hamers-Schneider
  • Patent number: 7935822
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: May 3, 2011
    Assignee: ATTO-TEC GmbH
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Publication number: 20060240455
    Abstract: Oxazine derivatives with which a broad spectrum of material to be studied can be labelled and identified by means of fluorescence techniques are described.
    Type: Application
    Filed: April 20, 2006
    Publication date: October 26, 2006
    Inventors: Joachim Fries, Eloisa Lopez-Calle, Karl-Heinz Drexhage
  • Patent number: 7101999
    Abstract: The invention relates to oxazine derivatives by means of which a broad spectrum of material to be examined can be marked and identified using fluorescence techniques.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: September 5, 2006
    Assignee: Evotec AG
    Inventors: Joachim Fries, Eloisa Lopez-Calle, Karl-Heinz Drexhage
  • Publication number: 20060179585
    Abstract: The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules.
    Type: Application
    Filed: July 2, 2004
    Publication date: August 17, 2006
    Applicant: ATTO-TEC GMBH
    Inventors: Alexander Zilles, Jutta Arden-Jacob, Karl-Heinz Drexhage, Norbert Kemnitzer, Monika Hamers-Schneider
  • Publication number: 20060154251
    Abstract: The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.
    Type: Application
    Filed: December 18, 2003
    Publication date: July 13, 2006
    Inventors: Jutta Arden-Jacob, Karl-Heinz Drexhage, Monika Hamers-Schneider, Norbert Kemnitzer, Alexander Zilles
  • Patent number: 6828159
    Abstract: The invention relates to the use of carbopyronine compounds of general formula (I) as marker groups in methods for detecting analytes. The invention also relates to novel carbopyronine compounds and to a method for producing same.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 7, 2004
    Inventors: Karl-Heinz Drexhage, Jutta Arden-Jacob, Jörg Frantzeskos, Alexander Zilles
  • Patent number: 6737280
    Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having structure (I) wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1-R8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinatios thereof, and R9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having general structure (II) where substituents R3-R7 correspond to like-referenced substituents in the structure of described above, and Y2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: May 18, 2004
    Assignee: Karl-Heinz Drexhage
    Inventors: Karl-Heinz Drexhage, Jutta Arden-Jacob, Norbert Kemnitzer