Patents by Inventor Karl-Heinz Wiesmuller

Karl-Heinz Wiesmuller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6984387
    Abstract: The present invention relates to FMDC vaccine based on peptides having a sequence of at least 8 amino acids, which corresponds to a partial sequence of the non-structural protein region of FMDV, which was selected by immunoreactivity with FMDV-specific antibodies or by immunoreactivity with FMDV-specific T lymphocytes, and to their production and their use.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: January 10, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roberto Correa, Hans-Robert Hehnen, Eberhard Pfaff, Armin Saalmüller, Thomas Pauly, Bettina Höhlich, Bernadette Glatthaar-Saalmüller, Karl-Heinz Wiesmüller
  • Publication number: 20050058656
    Abstract: The present invention relates to FMDC vaccine based on peptides having a sequence of at least 8 amino acids, which corresponds to a partial sequence of the non-structural protein region of FMDV, which was selected by immunoreactivity with FMDV-specific antibodies or by immunoreactivity with FMDV-specific T lymphocytes, and to their production and their use.
    Type: Application
    Filed: November 9, 2004
    Publication date: March 17, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Roberto Correa, Hans-Robert Hehnen, Eberhard Pfaff, Armin Saalmuller, Thomas Pauly, Bettina Hohlich, Bernadette Glatthaar-Saalmuller, Karl-Heinz Wiesmuller
  • Patent number: 6080719
    Abstract: The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in which A, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: June 27, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Birgit Jordan, Jochen Knolle, Leander Lauffer, Susanne Feiertag, Karl-Heinz Wiesmuller, Gunther Jung
  • Patent number: 6074650
    Abstract: According to certain embodiments, the invention relates to an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a protein of a virus, a bacterium, a parasite or a tumor antigen. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Jung, Karl-Heinz Wiesmuller, Hans-Georg Rammensee, Hansjorg Schild, Karl Deres
  • Patent number: 6024964
    Abstract: According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 15, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Jung, Karl-Heinz Wiesmuller, Jorg Metzger, Hans-Jorg Buhring, Gerhard Becker, Wolfgang Bessler
  • Patent number: 5869447
    Abstract: The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in whichA, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
    Type: Grant
    Filed: December 13, 1995
    Date of Patent: February 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Birgit Jordan, Jochen Knolle, Leander Lauffer, Susanne Feiertag, Karl-Heinz Wiesmuller, Gunther Jung
  • Patent number: 5700910
    Abstract: N-Acyl-S-(2-hydroxyalkyl)cysteines, their preparation and their use as intermediates for the preparation of synthetic immunoadjuvants and synthetic vaccines.Compounds of the formula I ##STR1## in which the substances X, Y, R, R.sup.1 and R.sup.2 have the meanings mentioned, are suitable for the preparation of lipopeptides and lipoamino acids.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jorg Metzger, Karl-Heinz Wiesmuller, Gunther Jung