Patents by Inventor Karl J. Schmalzi

Karl J. Schmalzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-oxo-4-carboxy-pyrimidines and their use as anti-malaria and anti-cancer agents
    Patent number: 4873228
    Abstract: A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) ##STR1## where either (i) A and B together are .dbd.Sor(ii) A is --H, and B is --COR.sub.2 or --SR.sub.6 ; andR.sub.1 and R.sub.2 which may be the same or different are --OH; alkyloxymethyl, a di-, tri- or polypeptide group, --OR where R is saturated or unsaturated C.sub.1-16 alkyl, C.sub.1-16 alkyloxymethyl, or 4-alkyl-piperidinyl-alkyl, --NR'R' where each R' is independently selected from --H, saturated or unsaturated C.sub.1-16 alkyl, or any group above to be hydrolyzed in vivo to hydroxy;R.sub.3 and R.sub.4 which may be the same or different are --H, C.sub.1-6 alkyl, hydroxy C.sub.1-16 alkyl, hydroxy C.sub.1-6 ether group, tetrahydrofuranyl, tetrahydropyranyl, a sugar or acetylated sugar group, hexylcarbamyl, methylglycine-N-carbonyl, or any group able to be hydrolyzed in vivo to --H;R.sub.5 is --H, halo, or C.sub.1-6 alkyl;R.sub.6 is C.sub.
    Type: Grant
    Filed: September 1, 1987
    Date of Patent: October 10, 1989
    Assignees: The University of Melbourne, The University of Sydney
    Inventors: Karl J. Schmalzi, Suresh C. Sharma, Richard I. Christopherson