Patents by Inventor Karl Rudolphi

Karl Rudolphi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8809358
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: August 19, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Patent number: 8518998
    Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: August 27, 2013
    Assignee: Sanofi-aventis Deutschland GmbH
    Inventors: Karl Rudolphi, Martin Michaelis, Hans Guehring
  • Publication number: 20110021505
    Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.
    Type: Application
    Filed: March 30, 2010
    Publication date: January 27, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl RUDOLPHI, Martin MICHAELIS, Hans GUEHRING
  • Publication number: 20090069358
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Application
    Filed: November 6, 2008
    Publication date: March 12, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Martin MICHAELIS, Olaf RITZELER, Gerhard JAEHNE, Karl RUDOLPHI, Gerd GEISSLINGER, Hans-Georg SCHAIBLE
  • Publication number: 20090023661
    Abstract: Peptides having bradykinin-antagonistic action are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases in whose course an increased activity of matrix metalloproteinases is involved. These include diseases such as degenerative joint diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or relatively long immobilization of a joint after meniscus or patella injuries or torn ligaments. The invention therefore relates to the use of a compound of the formula I, A-B-X-E-F-K-(D)-TIC-G-M-F?-I??(I) for the production of pharmaceuticals for the treatment of degenerative joint diseases, wherein A, B, X, E, F, K, (D)-TIC, G, M, F? and I are as defined herein.
    Type: Application
    Filed: September 25, 2008
    Publication date: January 22, 2009
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Martin Michaelis, Karl Rudolphi
  • Patent number: 7462638
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: December 9, 2008
    Assignee: SANOFI-AVENTIS Deutschland GmbH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Publication number: 20040248809
    Abstract: Peptides having bradykinin-antagonistic action are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases in whose course an increased activity of matrix metalloproteinases is involved. These include diseases such as degenerative joint diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or relatively long immobilization of a joint after meniscus or patella injuries or torn ligaments.
    Type: Application
    Filed: February 6, 2004
    Publication date: December 9, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Martin Michaelis, Karl Rudolphi
  • Publication number: 20040116494
    Abstract: The present invention relates to the use of I&kgr;B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Application
    Filed: August 18, 2003
    Publication date: June 17, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Patent number: 6214992
    Abstract: Theophylline derivatives having at least one ether function in the structurally modified methyl radical in the 1-position that are useful in the treatment and prophylaxis of states of shock, new xanthine compounds having this substitution pattern, and processes for their preparation.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: April 10, 2001
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Erhard Wolf, Elisabeth Defossa, Uwe Heinelt, Hiristo Anagnostopulos, Karl Rudolphi, John J. Grome
  • Patent number: 6037347
    Abstract: The invention relates to a composition which is a pharmaceutical combination preparation comprising a compound which has an acetylcholinesterase-inhibitory action or exhibits muscarinergic action and a compound which increases the endogenous extracellular adenosine level, wherein the combination preparation is suitable for the treatment of dementia. The invention further relates to a process for the production of the combination preparation. The invention additionally relates to a process for treating patients in need of suitable therapy with the combination preparation.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: March 14, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Peter Schubert, Hildegard Nimmesgern, Karl Rudolphi
  • Patent number: 5965555
    Abstract: Compounds of the formula I, ##STR1## in which one of the radicals R.sup.1 and R.sup.3 is an alkynol residue of the formula Ia or Ib ##STR2## are suitable for producing pharmaceuticals having a neuroprotective effect.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: October 12, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Elisabeth Defossa, Uwe Heinelt, Karl Rudolphi, John J. Grome
  • Patent number: 5478831
    Abstract: R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation, and pharmaceuticals which contain this compound and which are suitable, in particular, for the prophylaxis and treatment of cerebral vascular disorders.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: December 26, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Harald Furrer, Ulrich Gebert, Karl Rudolphi
  • Patent number: 5409935
    Abstract: The use of xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas (CCT)The use of xanthine derivatives of the formula I ##STR1## and of their physiologically tolerable salts, in which R.sup.1 is oxoalkyl, hydroxyalkyl or alkyl, R.sup.2 is hydrogen or alkyl and R.sup.3 is hydrogen, alkyl, oxoalkyl or an alkyl having up to 6 carbon atoms, whose carbon chain is interrupted by an oxygen atom, for the production of pharmaceuticals for the treatment of disorders which can occur after cranio-cerebral traumas is described.
    Type: Grant
    Filed: July 9, 1992
    Date of Patent: April 25, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Peter Schubert, John J. Grome, Barbara Kittner, Karl Rudolphi, Ulrich Gebert
  • Patent number: 5407815
    Abstract: R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation, and pharmaceuticals which contain this compound and which are suitable, in particular, for the prophylaxis and treatment of cerebral vascular disorders.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: April 18, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Harald Furrer, Ulrich Gebert, Karl Rudolphi