Patents by Inventor Karl Y. Hostetler

Karl Y. Hostetler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acyclic nucleoside phosphonate diesters
    Patent number: 10076533
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: September 18, 2018
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate compounds
    Patent number: 10071110
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 11, 2018
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20180071323
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 15, 2018
    Inventors: Karl Y. Hostetler, James R. Beadle, adejda Valiaeva
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20180064737
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 8, 2018
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • NUCLEOTIDE ANALOGS
    Publication number: 20180015095
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Nucleotide analogs
    Patent number: 9801884
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 31, 2017
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20170304330
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: June 8, 2017
    Publication date: October 26, 2017
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Acyclic nucleoside phosphonate diesters
    Patent number: 9775852
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 3, 2017
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • PHOSPHONATE COMPOUNDS
    Publication number: 20170239279
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: May 15, 2017
    Publication date: August 24, 2017
    Inventors: Karl Y. Hostetler, James R. Beadle
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20170189430
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonate compounds
    Patent number: 9649321
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: May 16, 2017
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle
  • Acyclic nucleoside phosphonate diesters
    Patent number: 9629860
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 25, 2017
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • PHOSPHONATES WITH REDUCED TOXICITY FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170096441
    Abstract: There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus.
    Type: Application
    Filed: September 9, 2016
    Publication date: April 6, 2017
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • NUCLEOTIDE ANALOGS
    Publication number: 20170037068
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Application
    Filed: June 2, 2016
    Publication date: February 9, 2017
    Applicant: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
    Publication number: 20170002033
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Application
    Filed: June 10, 2016
    Publication date: January 5, 2017
    Applicant: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Nucleotide analogs
    Patent number: 9493493
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: November 15, 2016
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Phosphonates with reduced toxicity for treatment of viral infections
    Patent number: 9475832
    Abstract: There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted salts and solvates thereof. There are also provided methods of using the disclosed compounds for inhibiting viral RNA-dependent RNA polymerase, inhibiting viral reverse transcriptase, inhibiting replication of virus, including hepatitis C virus or a human retrovirus, and treating a subject infected with a virus, including hepatitis C virus or a human retrovirus.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: October 25, 2016
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • Acyclic nucleoside phosphonate diesters
    Patent number: 9387217
    Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: July 12, 2016
    Assignee: The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • NUCLEOTIDE ANALOGS
    Publication number: 20160083407
    Abstract: Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 24, 2016
    Inventors: Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
  • PHOSPHONATE COMPOUNDS
    Publication number: 20160067268
    Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Inventors: Karl Y. Hostetler, James R. Beadle