Patents by Inventor Karola Tollmann

Karola Tollmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS
    Publication number: 20100273833
    Abstract: The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.
    Type: Application
    Filed: February 27, 2006
    Publication date: October 28, 2010
    Inventors: Wolfgang Albrecht, Cornelia Greim, Hans-Gunter Striegel, Karola Tollmann, Philipp Merkle, Stefan Laufer
  • IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT
    Publication number: 20100069436
    Abstract: The invention relates to imidazole derivatives of the Formula (I) in which the radicals R1, R2, R3, R4 and R5 have the meanings indicated in the description. The compounds of the invention have an immunomodulating and/or cytokine release-inhibiting effect and are therefore suitable for the treatment of disorders associated with an impairment of the immune system.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 18, 2010
    Applicant: Merckle
    Inventors: Wolfgang Albrecht, Dominik Hauser, Stefan Laufer, Hans-Gunter Striegel, Karola Tollmann
  • 2-thio-substituted imidazole derivatives and their use in pharmaceutics
    Patent number: 7582660
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and m are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: September 1, 2009
    Assignee: c-a-i-r biosciences GmbH
    Inventors: Stefan Laufer, Hans-Günter Striegel, Karola Tollmann, Wolfgang Albrecht
  • Dibenzocycloheptane compounds and pharmaceuticals containing these compounds
    Publication number: 20090105327
    Abstract: The present invention relates to compounds of the formula I in which R1, R2, R3, R4, X and Y have the meanings indicated in the description. These compounds have immunomodulating effects, as well as an inhibiting or regulating effect on the release of IL-1? and/or TNF-?. They can therefore be used for the treatment of diseases associated with a disturbance of the immune system.
    Type: Application
    Filed: May 12, 2006
    Publication date: April 23, 2009
    Applicant: Merckle GMBH
    Inventors: Stefan Laufer, Wolfgang Albrecht, Cornelia Greim, Hans-Guenter Striegel, Karola Tollmann
  • 2-thio-substituted imidazole derivatives and their use in pharmaceutics
    Patent number: 7442713
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3, R4 and p are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: October 28, 2008
    Assignee: Merckle GmbH
    Inventors: Stefan Laufer, Hans-Guenter Striegel, Wolfgang Albrecht, Karola Tollmann
  • 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
    Patent number: 7253191
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: August 7, 2007
    Assignee: Merckle GmbH
    Inventors: Stefan Laufer, Dunja Kotschenreuther, Philipp Merckle, Karola Tollmann, Hans-Guenter Striegel
  • 2-Thio-substituted imidazole derivatives and their use in pharmaceutics
    Publication number: 20060252810
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3, R4 and p are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Application
    Filed: May 16, 2003
    Publication date: November 9, 2006
    Inventors: Stefan Laufer, Hans-Guenter Striegel, Wolfgang Albrecht, Karola Tollmann
  • 2-Thio-substituted imidazole derivatives and their use in pharmaceutics
    Publication number: 20060235054
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2 R3 and m are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.
    Type: Application
    Filed: August 20, 2003
    Publication date: October 19, 2006
    Applicant: MERCKLE-GMBH
    Inventors: Stefan Laufer, Hans-Gunter Striegel, Karola Tollmann, Wolfgang Albrecht
  • Substituted isoxazole derivatives and their use in pharmaceutics
    Publication number: 20060128759
    Abstract: The invention relates to substituted isoxazole derivatives of formula (I), wherein the radicals R1, R2 and R3 have the meanings as cited in the description.
    Type: Application
    Filed: August 19, 2003
    Publication date: June 15, 2006
    Applicant: MERCKLE GMBH
    Inventors: Stefan Laufer, Hans-Gunter Striegel, Wolfgang Albrecht, Karola Tollmann
  • Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
    Patent number: 6936632
    Abstract: The present invention relates to fused pyrrole compounds of the formula 1. in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular pyrrolizines, indolizines and heteroanalogues having selective inhibitory action on isoenzyme-2 of prostaglandin H synthase (COX-2). The invention also relates to pharmaceutical compositions which contain these compounds; and the use of these compounds for the treatment of disorders of the rheumatic type.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: August 30, 2005
    Assignee: Merckle GmbH
    Inventors: Hans-Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
  • Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use
    Patent number: 6878738
    Abstract: The present invention relates to compounds of the formula I in which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8 and R9, together with the carbon atom to which they are bonded, are a carbonyl group and the radicals R1 to R7 have the meanings indicated in the description. The compounds inhibit the release of various mediators of the arachidonic acid cascade and can thus be used for the prevention of allergically induced disorders or for the treatment of disorders of the rheumatic type.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: April 12, 2005
    Assignee: Merckle GmbH
    Inventors: Stefan Laufer, Karola Tollmann, Hans-Guenter Striegel
  • 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy
    Patent number: 6867211
    Abstract: The present invention relates to 4-pyridyl- and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1: in which the variables have the meanings indicated in the description. The compounds according to the invention have immunomodulating and/or cytokine release-inhibiting action and are therefore utilizable for the treatment of disorders which are connected with a disturbance of the immune system.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: March 15, 2005
    Assignee: Merckle GmbH
    Inventors: Hans-Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
  • Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
    Publication number: 20040122002
    Abstract: The present invention relates to fused pyrrole compounds of the formula 1.
    Type: Application
    Filed: September 27, 2002
    Publication date: June 24, 2004
    Inventors: Hans Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
  • 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
    Publication number: 20040116416
    Abstract: The invention relates to 2-thio-substituted imidazole derivatives of the formula I 1
    Type: Application
    Filed: January 28, 2004
    Publication date: June 17, 2004
    Inventors: Stefan Laufer, Dunja Kotschenreuther, Philipp Merckle, Karola Tollmann, Hans-Gunter Striegel
  • 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy
    Publication number: 20030153558
    Abstract: The present invention relates to 4-pyridyl- und 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1 1
    Type: Application
    Filed: November 5, 2002
    Publication date: August 14, 2003
    Inventors: Hans-Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries