Patents by Inventor Karolina Madela

Karolina Madela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates in the synthesis of C3-substituted cephalosporins
    Patent number: 11840544
    Abstract: Disclosed herein are novel and inventive methods for preparing intermediates in the synthesis of C3-substituted cephalosporins. One preferred C3-substituted cephalosporin of clinical interest is Cefovecin. Accordingly, the present invention provides for methods of preparing reactive halogen intermediates for use in the synthesis of C3-substituted cephalosporins, such as Cefovecin.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: December 12, 2023
    Assignee: Norbrook Laboratories Limited
    Inventor: Karolina Madela
  • INTERMEDIATES IN THE SYNTHESIS OF C3-SUBSTITUTED CEPHALOSPORINS
    Publication number: 20210261571
    Abstract: Disclosed herein are novel and inventive methods for preparing intermediates in the synthesis of C3-substituted cephalosporins. One preferred C3-substituted cephalosporin of clinical interest is Cefovecin. Accordingly, the present invention provides for methods of preparing reactive halogen intermediates for use in the synthesis of C3-substituted cephalosporins, such as Cefovecin.
    Type: Application
    Filed: July 2, 2019
    Publication date: August 26, 2021
    Inventor: Karolina MADELA
  • ANTHELMINTHIC MACROLIDE SYNTHESIS
    Publication number: 20170355724
    Abstract: Disclosed herein is a novel and inventive synthesis of amino-deoxyavermectins, and in particular, the economically significant, anthelminthic macrolide eprinomectin. The synthesis proceeds via reductive amination of an intermediate in which the allylic alcohol of the benzofuran ring is deprotected. Advantageously, the method of the present invention obviates the need for chromatographic purification.
    Type: Application
    Filed: October 21, 2015
    Publication date: December 14, 2017
    Inventors: Andrzej Manikowski, Karolina Madela
  • Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
    Patent number: 9351989
    Abstract: This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structure wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: May 31, 2016
    Assignees: INHIBITEX, INC., UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
    Inventors: Chris McGuigan, Karolina Madela, Claire Bourdin, John Vernachio, Stanley Chamberlain
  • Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
    Patent number: 8759318
    Abstract: Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: June 24, 2014
    Assignees: Inhibitex, Inc., University College Cardiff Consultants Limited
    Inventors: Stanley Chamberlain, Jeff Hutchins, Karolina Madela, Christopher McGuigan, John Vernachio, Mohamed Aljarah, Arnaud Gilles
  • SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140140955
    Abstract: This invention is directed to novel compounds of formula (I) having the structure (I) wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. The compounds of formula (I) and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV).
    Type: Application
    Filed: December 29, 2011
    Publication date: May 22, 2014
    Applicants: UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED, INHIBITEX, INC.
    Inventors: Chris McGuigan, Karolina Madela, Claire Bourdin, John Vernachio, Stanley Chamberlain
  • Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections
    Publication number: 20120052046
    Abstract: Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
    Type: Application
    Filed: January 11, 2010
    Publication date: March 1, 2012
    Inventors: Stanley Chamberlain, Jeff Hutchins, Karolina Madela, Christopher McGuigam, John Vernachio, Mohamed Aljarah, Arnaud Gilles