Patents by Inventor Katherine L. Molnar-Kimber
Katherine L. Molnar-Kimber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7897733Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody.Type: GrantFiled: November 14, 2005Date of Patent: March 1, 2011Assignee: Pfizer, Inc.Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
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Patent number: 7279561Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monclonal antibody.Type: GrantFiled: May 24, 2000Date of Patent: October 9, 2007Assignee: WyethInventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
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Patent number: 7279562Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody.Type: GrantFiled: April 18, 2002Date of Patent: October 9, 2007Assignee: WyethInventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
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Publication number: 20040157775Abstract: This invention comprises antibodies to rapamycin effector proteins, and preparations thereof. Novel Rapamycin-FKBP12 binding proteins, nucleic acids and their fragments are also described, as are related methods and therapeutic uses of the proteins, nucleic acids, and antibodies.Type: ApplicationFiled: October 15, 2003Publication date: August 12, 2004Applicants: Wyeth, The Trustees of Columbia UniversityInventors: Thomas J. Caggiano, Yanqiu Chen, Amedeo A. Failli, Katherine L. Molnar-Kimber, Koji Nakanishi
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Patent number: 6713607Abstract: This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.Type: GrantFiled: September 13, 2001Date of Patent: March 30, 2004Assignee: WyethInventors: Thomas J. Caggiano, Yanqiu Chen, Amedeo A. Failli, Katherine L. Molnar-Kimber, Koji Nakanishi
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Patent number: 6541612Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.Type: GrantFiled: February 2, 2001Date of Patent: April 1, 2003Assignee: WyethInventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain, Amadeo A. Failli
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Publication number: 20030032775Abstract: This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.Type: ApplicationFiled: September 13, 2001Publication date: February 13, 2003Applicant: American Home ProductsInventors: Thomas J. Caggiano, Yanqiu Chen, Amedeo A. Failli, Katherine L. Molnar-Kimber, Koji Nakanishi
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Publication number: 20020151088Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody.Type: ApplicationFiled: April 18, 2002Publication date: October 17, 2002Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
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Patent number: 6328970Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.Type: GrantFiled: May 24, 2000Date of Patent: December 11, 2001Assignee: American Home Products CorporationInventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain, Amadeo A. Failli
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Patent number: 6313264Abstract: This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.Type: GrantFiled: June 6, 1995Date of Patent: November 6, 2001Assignees: American Home Products Corporation, The Trustees of Columbia UniversityInventors: Thomas J. Caggiano, Yanqiu Chen, Amedeo A. Failli, Katherine L. Molnar-Kimber, Koji Nakanishi
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Publication number: 20010010920Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.Type: ApplicationFiled: February 2, 2001Publication date: August 2, 2001Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain, Amadeo A. Failli
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Patent number: 5504091Abstract: A compound of the structure ##STR1## R.sup.1 and R.sup.2 are each, independently, hydrogen or ##STR2## X is ##STR3## Y is ##STR4## Z is --CH.sub.2 --, --S--S--, or ##STR5## R.sup.3 is hydrogen, alkyl, arylalkyl, alkenyl, alkynyl, --(CH.sub.2).sub.q CO.sub.2 R.sup.5, --(CH.sub.2).sub.r NR.sup.6 R.sup.7, carbamylalkyl, aminoalkyl, hydroxyalkyl, guanylalkyl, mercaptoalkyl, alkylthioalkyl, indolylmethyl, hydroxyphenylmethyl, imidazoylmethyl, halo, trifluoromethyl, or phenyl which is optionally mono-, di-, or tri-substituted;R.sup.4, R.sup.6, and R.sup.7 are each, independently, hydrogen, alkyl, or arylalkyl;R.sup.5 is hydrogen, alkyl, arylalkyl, alkenyl, alkynyl, or phenyl which is optionally mono-, di-, or tri-substituted;h=0-1;j=0-1;m=0-6;n=0-6;p=0-10;q=0-10;r=0-6;with the proviso that R.sup.1 and R.sup.2 are not both hydrogen, or a pharmaceutically acceptable salt thereof which is useful for inducing immunosuppression; in the treatment of transplantation rejection, host vs.Type: GrantFiled: April 14, 1994Date of Patent: April 2, 1996Assignee: American Home Products CorporationInventors: Katherine L. Molnar-Kimber, Timothy D. Ocain, Steven K. Vernon, John J. Huang