Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: Monitoring an operational characteristic of a data communication device within a network includes sampling an operational characteristic of the data communication device at a fine-grain sample rate over a first sampling interval to produce fine-grain samples of the operational characteristic of the data communication device, training a machine learning algorithm using the fine-grain samples of the operational characteristic of the data communication device, the fine-grain sample rate, and a coarse-grain sample rate that is less than the fine-grain sample rate, sampling the operational characteristic of the data communication device at the coarse-grain sample rate over a second sampling interval to produce coarse-grain samples of the operational characteristic of the data communication device, and using the machine learning algorithm to process the coarse-grain samples of the operational characteristic of the data communication device to produce accuracy-enhanced samples of the operational characteristic of th

Abstract: Techniques are presented to stitch existing virtual private networks (VPNs), such as MPLS based VPNs, with virtual private clouds (VPCs) in public cloud data centers. The stitching architecture can be realized by configuring a virtual routing application (VRA) in the VPCs and configuring virtual routing applications and a virtual routing application controller in the existing VPN. For VPCs in public clouds that do not have a VRA, traffic can be default routed to VPCs with a VRA.

Abstract: Techniques are presented to stitch existing virtual private networks (VPNs), such as MPLS based VPNs, with virtual private clouds (VPCs) in public cloud data centers. The stitching architecture can be realized by configuring a virtual routing application (VRA) in the VPCs and configuring virtual routing applications and a virtual routing application controller in the existing VPN. For VPCs in public clouds that do not have a VRA, traffic can be default routed to VPCs with a VRA.

Abstract: According to one aspect of the present disclosure, a system includes an active network element having circuitry for executing a primary application and a transmission control protocol (TCP) module, multiple standby network elements having circuitry for executing a secondary copy of the primary application and a secondary TCP module, and a network connection coupled to one or more of the active and standby network elements, wherein the active network element and standby network elements are coupled to transfer data and acknowledgments via their respective TCP modules, and wherein the standby network elements are reconfigurable to communicate via the network connection to a peer regardless of the failure of one or two of the network elements.

Abstract: Monitoring an operational characteristic of a data communication device within a network includes sampling an operational characteristic of the data communication device at a fine-grain sample rate over a first sampling interval to produce fine-grain samples of the operational characteristic of the data communication device, training a machine learning algorithm using the fine-grain samples of the operational characteristic of the data communication device, the fine-grain sample rate, and a coarse-grain sample rate that is less than the fine-grain sample rate, sampling the operational characteristic of the data communication device at the coarse-grain sample rate over a second sampling interval to produce coarse-grain samples of the operational characteristic of the data communication device, and using the machine learning algorithm to process the coarse-grain samples of the operational characteristic of the data communication device to produce accuracy-enhanced samples of the operational characteristic of th

Abstract: Monitoring an operational characteristic of a data communication device within a network includes sampling an operational characteristic of the data communication device at a fine-grain sample rate over a first sampling interval to produce fine-grain samples of the operational characteristic of the data communication device, training a machine learning algorithm using the fine-grain samples of the operational characteristic of the data communication device, the fine-grain sample rate, and a coarse-grain sample rate that is less than the fine-grain sample rate, sampling the operational characteristic of the data communication device at the coarse-grain sample rate over a second sampling interval to produce coarse-grain samples of the operational characteristic of the data communication device, and using the machine learning algorithm to process the coarse-grain samples of the operational characteristic of the data communication device to produce accuracy-enhanced samples of the operational characteristic of th

Abstract: Techniques are presented to stitch existing virtual private networks (VPNs), such as MPLS based VPNs, with virtual private clouds (VPCs) in public cloud data centers. The stitching architecture can be realized by configuring a virtual routing application (VRA) in the VPCs and configuring virtual routing applications and a virtual routing application controller in the existing VPN. For VPCs in public clouds that do not have a VRA, traffic can be default routed to VPCs with a VRA.

Abstract: Embodiments relate generally to systems and methods for transitioning a system from a tradition network to a Software Defined Network (SDN) enabled network. In some embodiments, the systems and methods may comprise the use of a Path Computation Element (PCE) as a central controller. Smooth transition between traditional network and the new SDN enabled network, especially from a cost impact assessment perspective, may be accomplished using the existing PCE components from the current network to function as the central controller of the SDN network is one choice, which not only achieves the goal of having a centralized controller to provide the functionalities needed for the central controller, but also leverages the existing PCE network components.

Abstract: Techniques are presented to stitch existing virtual private networks (VPNs), such as MPLS based VPNs, with virtual private clouds (VPCs) in public cloud data centers. The stitching architecture can be realized by configuring a virtual routing application (VRA) in the VPCs and configuring virtual routing applications and a virtual routing application controller in the existing VPN. For VPCs in public clouds that do not have a VRA, traffic can be default routed to VPCs with a VRA.

Abstract: Embodiments relate generally to systems and methods for transitioning a system from a tradition network to a Software Defined Network (SDN) enabled network. In some embodiments, the systems and methods may comprise the use of a Path Computation Element (PCE) as a central controller. Smooth transition between traditional network and the new SDN enabled network, especially from a cost impact assessment perspective, may be accomplished using the existing PCE components from the current network to function as the central controller of the SDN network is one choice, which not only achieves the goal of having a centralized controller to provide the functionalities needed for the central controller, but also leverages the existing PCE network components.

Abstract: A method for performing virtual private cloud (VPC) routing across multiple public cloud environments. In an embodiment, the method creates a first virtual routing agent (VRA) for a first VPC of a first public cloud. The method sends a registration request to a VRA controller, wherein the registration request comprises a data structure that includes communication parameters of the first VRA. The method receives the communication parameters of other VRAs for other VPCs located in other public cloud environments from the VRA controller. The method uses the communication parameters of the other VRAs for overlay routing of data packets from the first VPC of the first public cloud to other VPCs of other public clouds via the other VRAs of the other VPCs.

Abstract: Embodiments relate generally to systems and methods for transitioning a system from a tradition network to a Software Defined Network (SDN) enabled network. In some embodiments, the systems and methods may comprise the use of a Path Computation Element (PCE) as a central controller. Smooth transition between traditional network and the new SDN enabled network, especially from a cost impact assessment perspective, may be accomplished using the existing PCE components from the current network to function as the central controller of the SDN network is one choice, which not only achieves the goal of having a centralized controller to provide the functionalities needed for the central controller, but also leverages the existing PCE network components.

Abstract: Monitoring an operational characteristic of a data communication device within a network includes sampling an operational characteristic of the data communication device at a fine-grain sample rate over a first sampling interval to produce fine-grain samples of the operational characteristic of the data communication device, training a machine learning algorithm using the fine-grain samples of the operational characteristic of the data communication device, the fine-grain sample rate, and a coarse-grain sample rate that is less than the fine-grain sample rate, sampling the operational characteristic of the data communication device at the coarse-grain sample rate over a second sampling interval to produce coarse-grain samples of the operational characteristic of the data communication device, and using the machine learning algorithm to process the coarse-grain samples of the operational characteristic of the data communication device to produce accuracy-enhanced samples of the operational characteristic of th

Abstract: Techniques are presented to stitch existing virtual private networks (VPNs), such as MPLS based VPNs, with virtual private clouds (VPCs) in public cloud data centers. The stitching architecture can be realized by configuring a virtual routing application (VRA) in the VPCs and configuring virtual routing applications and a virtual routing application controller in the existing VPN. For VPCs in public clouds that do not have a VRA, traffic can be default routed to VPCs with a VRA.

Abstract: According to one aspect of the present disclosure, a system includes an active network element having circuitry for executing a primary application and a transmission control protocol (TCP) module, multiple standby network elements having circuitry for executing a secondary copy of the primary application and a secondary TCP module, and a network connection coupled to one or more of the active and standby network elements, wherein the active network element and standby network elements are coupled to transfer data and acknowledgments via their respective TCP modules, and wherein the standby network elements are reconfigurable to communicate via the network connection to a peer regardless of the failure of one or two of the network elements.

Abstract: A method for performing virtual private cloud (VPC) routing across multiple public cloud environments. In an embodiment, the method creates a first virtual routing agent (VRA) for a first VPC of a first public cloud. The method sends a registration request to a VRA controller, wherein the registration request comprises a data structure that includes communication parameters of the first VRA. The method receives the communication parameters of other VRAs for other VPCs located in other public cloud environments from the VRA controller. The method uses the communication parameters of the other VRAs for overlay routing of data packets from the first VPC of the first public cloud to other VPCs of other public clouds via the other VRAs of the other VPCs.

Abstract: Embodiments relate generally to systems and methods for transitioning a system from a tradition network to a Software Defined Network (SDN) enabled network. In some embodiments, the systems and methods may comprise the use of a Path Computation Element (PCE) as a central controller. Smooth transition between traditional network and the new SDN enabled network, especially from a cost impact assessment perspective, may be accomplished using the existing PCE components from the current network to function as the central controller of the SDN network is one choice, which not only achieves the goal of having a centralized controller to provide the functionalities needed for the central controller, but also leverages the existing PCE network components.

Abstract: According to one aspect of the present disclosure, a system includes an active network element having circuitry for executing a primary application and a transmission control protocol (TCP) module, multiple standby network elements having circuitry for executing a secondary copy of the primary application and a secondary TCP module, and a network connection coupled to one or more of the active and standby network elements, wherein the active network element and standby network elements are coupled to transfer data and acknowledgments via their respective TCP modules, and wherein the standby network elements are reconfigurable to communicate via the network connection to a peer regardless of the failure of one or two of the network elements.

Abstract: A computer-implemented method of routing protection is provided comprising: receiving, by one or more processors of an active network element from a remote peer device, a plurality of data packets; sending, by the one or more processors of the active network element to a plurality of standby network elements, a multicast data packet comprising combined data of the plurality of data packets; receiving, by the one or more processors of the active network element from at least one of the standby network elements, an acknowledgment of receipt of the multicast data packet; and in response to the receipt of the acknowledgment, sending, by the one or more processors of the active network element to the remote peer device, an acknowledgment of receipt of the plurality of data packets.