Patents by Inventor Katsuhiro Ogasa

Katsuhiro Ogasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4342828
    Abstract: A colony stimulating factor effective in treating human granulocytopenia is produced by cultivating monocytes and macrophages isolated from the human peripheral blood in a synthetic medium for tissue culture containing a glycoprotein isolated from human urine and capable of stimulating the formation of human granulocytes or mouse macrophages and granulocytes.
    Type: Grant
    Filed: July 15, 1980
    Date of Patent: August 3, 1982
    Assignees: Morinaga Milk Industry Co., Ltd., The Green Cross Corp.
    Inventors: Fumimaro Takaku, Katsuhiro Ogasa, Morio Kuboyama, Nobuya Yanai, Muneo Yamada, Yoshiteru Watanabe
  • Patent number: 4303678
    Abstract: A method of manufacturing a packaged soybean curd with a long shelf life without the inclusion of any artificial additives such as coagulating agents, germicides and the like; wherein soybean juice is subjected to lactic acid fermentation until its pH is reached to a value equal to or less than a value which is determined from the percentage of the solids content (5-16 wt. %) of soybean juice and then is subjected to heating (60.degree.-95.degree. C., 10-100 minutes) to adjust the curd tension to above 20 g.
    Type: Grant
    Filed: August 1, 1980
    Date of Patent: December 1, 1981
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Morio Kuboyama, Kunisuke Kuwahara, Ryo Kato, Hiroshi Shimada
  • Patent number: 4275056
    Abstract: A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinitive chromatography with sugar affinitire adsorbents and electrophoresis.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: June 23, 1981
    Assignees: Morinaga Milk Industry Co., Ltd., The Green Cross Corporation
    Inventors: Fumimaro Takaku, Katsuhiro Ogasa, Morio Kuboyama, Minoru Saito, Nobuya Yanai, Masayuki Nishida
  • Patent number: 4230697
    Abstract: A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
    Type: Grant
    Filed: May 9, 1979
    Date of Patent: October 28, 1980
    Assignees: Morinaga Milk Industry Co. Ltd., The Green Cross Corporation
    Inventors: Masayuki Nishida, Satoshi Funakoshi, Katsuhiro Ogasa, Morio Kuboyama, Nobuya Yanai, Muneo Yamada
  • Patent number: 4226847
    Abstract: Latex reagents for quantitative assay of a variety of steroid hormones or metabolites thereof which are contained in body fluid or excreted fluid of human beings comprise latex particles which are immunologically sensitized with a conjugate selected from a variety of steroid-serum albumin conjugates in which the steroid to be detected is bonded to serum albumin in a very small ratio ranging from 0.5 to 7 molecules per 1 molecule of the serum albumin used.Sensitization of latex particles with such a conjugate is performed using a limited amount dependent on the bonding ratio of steroid molecules per molecule of serum albumin in the conjugate and the particle size of the latex used.The latex reagents show very high sensitivity amounting to 0.2-0.04 nmole steroid equivalent/ml.
    Type: Grant
    Filed: June 20, 1978
    Date of Patent: October 7, 1980
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Morio Kuboyama, Minoru Saito, Tsutomu Kudo, Yoshitsugu Harada, Akio Kawashiri, Eiji Takahashi
  • Patent number: 4147773
    Abstract: An orally administered powdery composition comprising freeze dried viable cell mass of the genus Bifidobacterium and powdered lactulose is effective for the establishment of favorable Bifidobacteria in cases of abnormal intestinal flora.The composition contains viable cell mass of the genus Bifidobacterium, has a high cell density not less than 8.times.10.sup.10 per gram, and exhibits a high cell survival rate over a long period of storage.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: April 3, 1979
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventor: Katsuhiro Ogasa
  • Patent number: 4142916
    Abstract: Method for manufacturing a lactulose powder with a low hygroscopicity by mixing ethyl alcohol to a highly hygroscopic lactulose-containing powder followed by allowing the resulting mixture to stand or stirring it for at least 1 hour, separating the lactulose-containing material insoluble in ethyl alcohol from the mixture and removing ethyl alcohol from the material separated.
    Type: Grant
    Filed: May 3, 1978
    Date of Patent: March 6, 1979
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Mamoru Tomita, Teruhiko Mizota
  • Patent number: 4140811
    Abstract: A method for manufacturing rough textured soya bean curd of long shelf life from conventional soya bean juice comprises the steps of heat-sterilizing the soya bean juice, adding a coagulant to the sterilized soya bean juice to form coagulum, adjusting the water content of the coagulum to 78% to 90% by weight, packing the adjusted coagulum into a container followed by hermetically sealing and shaping the coagulum by heating.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: February 20, 1979
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Kunisuke Kuwahara, Rye Kato
  • Patent number: 4100022
    Abstract: A process for preparing a therapeutic agent characterized by preculturing human amnion cells isolated from human amnion by trypsinization or human amnion cells obtained by subculturing the isolated cells in a medium containing calf or bovine fetal serum at least one time for 1 to 5 days to form a monolayer, removing the medium, adding a medium containing 0.5 to 20 mg of human serum albumin per 1 ml of medium thereto and culturing it for 3 to 6 days, dialyzing the culture liquid against diluted buffer or water, and filtering the dialyzed culture liquid through a bacterial filter thereby obtaining a germ free liquid agent.
    Type: Grant
    Filed: September 29, 1976
    Date of Patent: July 11, 1978
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Morio Kuboyama, Minoru Saito, Kazuhiro Nagata
  • Patent number: 4057655
    Abstract: A process for preparing a free-flowing lactulose-containing powder from a solution containing lactose, by adding calcium hydroxide to the solution to adjust the pH of said solution to from 9.4 to 11.2; heating the resulting solution so that the pH is reduced to from 7.5 to 9.0; the homogenizing, concentrating and drying.
    Type: Grant
    Filed: July 6, 1976
    Date of Patent: November 8, 1977
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuto Okada, Katsuhiro Ogasa, Mamoru Tomita
  • Patent number: 4039386
    Abstract: A method of determining the viable bacterial count of food which comprises incubating said food in a liquified agar medium which contains from 0.005 to 0.1 gram per liter of said liquified agar medium 2, 3, 5-triphenyl tetrazolium chloride as an inhibitor of bacteria colony spreading, and counting the bacteria colonies.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: August 2, 1977
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Seiichi Shimamura, Hiroshi Miyagawa
  • Patent number: 4038992
    Abstract: A granular composition having a grain size of 10 to 50 mesh and a bulk density of 0.5 to 0.7 g/cm.sup.3 suitable for use in a tobacco filter or a tobacco pipe and having the ability to selectively remove carcinogenic and deleterious components from tobacco smoke comprises granules which are composed of bovine milk whey protein power and/or egg white protein powder, and one or more excipients selected from the group consisting of powdered cellulose, wheat flour, starch, rice flour, sugar, glucose, lactose, talc, alumina, zeolite or silica gel; or composite granules which are a blend of said granules and charcoal granules.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: August 2, 1977
    Assignees: The Japan Tobacco & Salt Public Corporation, Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Joji Ono, Tsutomu Kudo, Kazuyoshi Doi, Katsuichi Noguchi, Kazuo Maeda
  • Patent number: 4000326
    Abstract: Packaged aseptic soya bean curd containing no bactericidal agents is manufactured by a method which comprises continuously sterilizing a soya bean juice by maintaining it at a temperature of 128.degree. to 150.degree. C for 1 to 6 seconds and cooling to room temperature; homogeneously mixing said sterilized soya bean juice with a sterilized coagulating agent-containing solution in an aseptic atmosphere continuously or in a pipeline; continuously filling the resulting liquid mixture into a container in an aseptic atmosphere and sealing it; and dipping said sealed container into a water tank heated to 70.degree. to 95.degree. C for 20 to 60 minutes in order to coagulate the mixture.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: December 28, 1976
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuto Okada, Katsuhiro Ogasa, Kunisuke Kuwahara
  • Patent number: 3968267
    Abstract: A whipped-cream topping dessert is prepared by a process comprising the steps of: (a) formulating an aqueous mixture containing 10 to 30 percent by weight of fat, 3 to 6 percent by weight of milk protein, 12 to 22 percent by weight of saccharide, 0.3 to 0.8 percent by weight of emulsifier, 0.05 to 0.15 percent by weight of thickening agent and 0.3 to 0.6 percent by weight of gelling agent; (b) homogenizing said mixture; (c) pasteurizing and cooling the mixture to room temperature; (d) thereafter adding an aqueous solution of a calcium salt to said mixture so that the amount of calcium ion in said mixture is 10 to 35 mg. per 1 gram of the milk protein; (e) whipping and heating the resultant mixture at a temperature of 25.degree. to 30.degree.C to prepare a flowable whipped-cream; (f) topping said whipped-cream onto a lower layer dessert base maintained at a temperature of 50.degree. to 70.degree.C which has previously been placed into a container; and (g) solidifying both layers by cooling.
    Type: Grant
    Filed: June 13, 1975
    Date of Patent: July 6, 1976
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Katsuhiro Ogasa, Shigeo Okonogi, Hiroya Yuguchi, Yoshinobu Hayashi, Yusuke Miyazaki