Patents by Inventor Katsuhisa Sakaguchi

Katsuhisa Sakaguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200291350
    Abstract: The presently disclosed subject matter is to provide a hepatocyte structure, particularly, a hepatocyte structure that mimics nonalcoholic steatohepatitis (NASH). A hepatocyte construct including an aggregate containing hepatocytes and adherent cells that are non-hepatocytes, and wherein the hepatocytes include ballooned hepatocytes is provided. Further, a method for producing a hepatocyte construct, comprising: (i) forming an aggregate by aggregating a cell group comprising hepatocytes and adherent cells that are non-hepatocytes; and (ii) culturing the aggregate is provided.
    Type: Application
    Filed: July 3, 2019
    Publication date: September 17, 2020
    Applicants: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Botao GAO, Yuki KAGAWA, Tetsuya OGAWA, Hirotsugu KUBO, Tatsuya SHIMIZU, Katsuhisa SAKAGUCHI
  • Publication number: 20180155673
    Abstract: An object of the present invention is to obtain a thicker animal cell composition by a simple and less expensive method. Namely, an object of the present invention is to provide a method for culturing a thicker animal cell composition by eliminating the hypoxia associated with animal cell compositions, a method for producing an animal cell composition containing unicellular algae, and an animal cell composition. The present invention provides a method for culturing an animal cell composition in a culture medium in the presence of unicellular algae and under exposure to light. According to the method of the present invention, oxygen can be continuously supplied in the culture medium, cell damage is alleviated, and a thicker cell composition can be obtained in the absence of a capillary network.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 7, 2018
    Applicant: Tokyo Women's Medical University
    Inventors: Tatsuya Shimizu, Yuji Haraguchi, Yuki Kagawa, Katsuhisa Sakaguchi
  • Patent number: 9617519
    Abstract: A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: April 11, 2017
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Katsuhisa Sakaguchi, Tatsuya Shimizu, Hidekazu Sekine, Mitsuo Umezu, Teruo Okano
  • Patent number: 9253975
    Abstract: Disclosed herein is a tool, a kit, and associated method for transferring a membranous tissue composed of cells derived from a living body. The tool can include a first sheet-like supporting member disposed on one side of the membranous tissue in a wet state, and a second sheet-like supporting member disposed on the other side of the membranous tissue in a wet state. The first supporting member and the second supporting member can be configured to entirely hold the membranous tissue, such that a frictional force between the first supporting member and the membranous tissue is larger than a frictional force between the second supporting member and the membranous tissue.
    Type: Grant
    Filed: May 12, 2012
    Date of Patent: February 9, 2016
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Ryohei Takeuchi, Tatsuya Shimizu, Katsuhisa Sakaguchi
  • Publication number: 20130173018
    Abstract: A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.
    Type: Application
    Filed: September 14, 2011
    Publication date: July 4, 2013
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Katsuhisa Sakaguchi, Tatsuya Shimizu, Hidekazu Sekine, Mitsuo Umezu, Teruo Okano
  • Publication number: 20130051969
    Abstract: Disclosed herein is a tool, a kit, and associated method for transferring a membranous tissue composed of cells derived from a living body. The tool can include a first sheet-like supporting member disposed on one side of the membranous tissue in a wet state, and a second sheet-like supporting member disposed on the other side of the membranous tissue in a wet state. The first supporting member and the second supporting member can be configured to entirely hold the membranous tissue, such that a frictional force between the first supporting member and the membranous tissue is larger than a frictional force between the second supporting member and the membranous tissue.
    Type: Application
    Filed: May 12, 2012
    Publication date: February 28, 2013
    Inventors: Ryohei Takeuchi, Tatsuya Shimizu, Katsuhisa Sakaguchi
  • Patent number: 7633027
    Abstract: A switch mechanism usable underwater including a cover serving as an exterior member, a shaft member displaceable in a longitudinal direction and fitted into a shaft hole having substantially the same cross-sectional area provided in the cover, an O-ring maintaining a water-tight sliding seal between the shaft member and the shaft hole, and a lever member movable about an axis for moving the shaft member by application of a pressing force applied to the lever member in a first direction against a force of a bias member, the pressing force being applied at a first point which is a first distance from said axis, the lever member engaging the shaft at a second point a second distance from said axis which is less than said first distance to move the lever member in a second direction opposite said first direction when the pressing force is removed.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: December 15, 2009
    Assignee: Olympus Imaging Corp.
    Inventors: Katsuhisa Sakaguchi, Naoki Matsumoto, Tsuyoshi Hirabayashi
  • Patent number: 7598465
    Abstract: The present invention provides a switch mechanism usable underwater including a rear cover serving as an exterior member, two shaft members being displaceable in a shaft direction and fitting into two shaft holes having the same cross-sectional area provided in the rear cover, an O-ring watertightly maintaining the shaft member and the shaft hole, and a lever member being engaged with the two shaft members in a manner to be capable of pressing-down or pulling-up the shaft member, and being configured to balance water pressure applied to one shaft member with that applied to the other shaft member.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: October 6, 2009
    Assignee: Olympus Imaging Corp.
    Inventors: Tsuyoshi Hirabayashi, Katsuhisa Sakaguchi, Ikko Mori
  • Publication number: 20090014297
    Abstract: A switch mechanism usable underwater including a cover serving as an exterior member, a shaft member displaceable in a longitudinal direction and fitted into a shaft hole having substantially the same cross-sectional area provided in the cover, an O-ring maintaining a water-tight sliding seal between the shaft member and the shaft hole, and a lever member movable about an axis for moving the shaft member by application of a pressing force applied to the lever member in a first direction against a force of a bias member, the pressing force being applied at a first point which is a first distance from said axis, the lever member engaging the shaft at a second point a second distance from said axis which is less than said first distance to move the lever member in a second direction opposite said first direction when the pressing force is removed.
    Type: Application
    Filed: August 15, 2008
    Publication date: January 15, 2009
    Applicant: OLYMPUS IMAGING CORP.
    Inventors: Katsuhisa Sakaguchi, Ikko Mori, Naoki Matsumoto, Tsuyoshi Hirabayashi
  • Publication number: 20080308396
    Abstract: The present invention provides a switch mechanism usable underwater including a rear cover serving as an exterior member, two shaft members being displaceable in a shaft direction and fitting into two shaft holes having the same cross-sectional area provided in the rear cover, an O-ring watertightly maintaining the shaft member and the shaft hole, and a lever member being engaged with the two shaft members in a manner to be capable of pressing-down or pulling-up the shaft member, and being configured to balance water pressure applied to one shaft member with that applied to the other shaft member.
    Type: Application
    Filed: August 15, 2008
    Publication date: December 18, 2008
    Applicant: OLYMPUS IMAGING CORP.
    Inventors: Naoki Matsumoto, Ikko Mori, Katsuhisa Sakaguchi, Tsuyoshi Hirabayashi
  • Publication number: 20060113173
    Abstract: The present invention provides a switch mechanism usable underwater including a rear cover serving as an exterior member, two shaft members being displaceable in a shaft direction and fitting into two shaft holes having the same cross-sectional area provided in the rear cover, an O-ring watertightly maintaining the shaft member and the shaft hole, and a lever member being engaged with the two shaft members in a manner to be capable of pressing-down or pulling-up the shaft member, and being configured to balance water pressure applied to one shaft member with that applied to the other shaft member.
    Type: Application
    Filed: November 17, 2005
    Publication date: June 1, 2006
    Applicant: OLYMPUS IMAGING CORP.
    Inventors: Naoki Matsumoto, Ikko Mori, Katsuhisa Sakaguchi, Tsuyoshi Hirabayashi