Patents by Inventor Katsuo Hatayama
Katsuo Hatayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5990151Abstract: The present invention relates to an optically active, substituted phenylalkylamine derivative represented by Formula [1]: ##STR1## wherein A is a substituted or non-substituted phenyl or thienyl; X.sup.1 is hydrogen, halogen, hydroxyl or a substituted or non-substituted C.sub.1-5 alkoxy; R.sup.1 and R.sup.2 are equally or differently hydrogen, C.sub.1-7 alkyl, C.sub.3-7 alkenyl or C.sub.3-7 alkynyl; R.sup.3 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl or C.sub.2-10 alkynyl; n is an integer from 2 to 5; and m is an integer from 1 to 4,or a pharmaceutically acceptable salt thereof, and pharmaceutical use of such compound or salt. The compound of the invention is excellent in sigma 1 receptor antagonism and useful for treating schizophrenia, depression, anxiety, cerebrovascular diseases/senile troublesome behaviors, and cognitive dysfunctions and motor dysfunctions such as Alzheimer's disease, Parkinson's disease and Huntington's disease which are neurodegenerative diseases.Type: GrantFiled: May 15, 1998Date of Patent: November 23, 1999Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Toshihito Kumagai, Tomoki Miyazawa, Koumei Ohta, Yutaka Kawashima, Katsuo Hatayama, deceased
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Patent number: 5753673Abstract: Quinolinecarboxylic acid derivatives represented by the following formula: ##STR1## wherein C is hydroxymethyl, methoxy, ethoxy or morpholinyl, or pharmaceutically acceptable salts thereof exhibit a potent action for stimulating a serotonin 4 receptor. The compounds exhibit an action of enhancing the gastrointestinal motor function to improve the gastrointestinal conditions such as heartburn, anorexia, bowel pain, abdominal distension, etc., accompanied by chronic gastritis, diabetes mellitus or postoperative gastroparesis, and are thus effective for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction and constipation.Type: GrantFiled: January 18, 1996Date of Patent: May 19, 1998Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama
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Patent number: 5733917Abstract: Endo-(8-methyl-8-azabicyclo?3.2.1!oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I): ##STR1## or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.Type: GrantFiled: August 21, 1996Date of Patent: March 31, 1998Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama, Yoshihiko Isobe, Haruko Kijima, Makoto Muramatsu
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Patent number: 5712263Abstract: To provide novel steroid derivatives having an antitumor action which can be synthesized efficiently and stereoselectively by means of synthetic organic chemistry. A steroid derivative represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 13 carbon atoms, A is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, X and Y together form an oxo group or an alkylenedioxy group having 2 or 3 carbon atoms, X is a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom or an alkoxy group having 1 to 5 carbon atoms, with the proviso that when X is a hydroxyl group or a group easily hydrolyzable to a hydroxyl group, Y is a hydrogen atom, and when X is an alkoxy group having 1 to 5 carbon atoms, Y is an alkoxy group having 1 to 5 carbon atoms, or a salt thereof.Type: GrantFiled: June 14, 1996Date of Patent: January 27, 1998Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Chihiro Yokoo, Hisaya Wada, Hidemichi Mitome, Tatsuhiko Sano, Katsuo Hatayama, Yasuji Yamada
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Patent number: 5672712Abstract: Object: To provide compounds useful as inhibitors of blood platelet aggregation for intravenous administration.Constitution: A thiazoline derivative represented by the formula: ##STR1## ?wherein R.sup.1 is a hydroxyl group, an alkoxy group, a cycloalkoxy group or a group represented by the formula: R.sup.4 NH-- (wherein R.sup.4 is a cycloalkyl group), R.sup.2 is an alkyl group, a cycloalkyl group or a phenylalkyl group, R.sup.3 is a hydrogen atom or an alkyl group, and n is an integer of 2 to 9! or a salt thereof.Type: GrantFiled: December 12, 1996Date of Patent: September 30, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Akira Manaka, Keiko Takahashi, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5631354Abstract: Object:Provision of novel macrolide antibiotics having a strong antibacterial activity.Construction:Compounds represented by the formula: ##STR1## which are obtained by introducing a certain substituted carbonyloxy group into 5-O-desosaminylerythronolide derivatives at the 3-position; and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: June 21, 1994Date of Patent: May 20, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshifumi Asaka, Yoko Misawa, Masato Kashimura, Shigeo Morimoto, Katsuo Hatayama
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Patent number: 5631355Abstract: Object: To provide novel macrolide antibiotics having a strong antibacterial activity. Constitution: 5-O-desosaminylerythronolide A derivatives represented by the formula: ##STR1## [wherein -A- - is a group of --N(R.sup.3)-- (wherein R.sup.3 is a hydrogen atom or an alkyl group having 1-3 carbon atoms) or a group represented by --N.dbd., and R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl group having 1-3 carbon atoms] which is a tricyclic carbamate of 5-0-desosaminylerythronolide A derivative having a ketone at the 3-position, being substituted by a methoxy group at the 6-position, and a pharmaceutically acceptable acid addition salt thereof; and a compound represented by the formula: ##STR2## (wherein R.sup.4 is an acetyl group or a propionyl group) which is an intermediate useful for the preparation of the 3-ketone forms of 5-O-desosaminylerythronolide A derivatives.Type: GrantFiled: October 17, 1994Date of Patent: May 20, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshifumi Asaka, Masato Kashimura, Yoko Misawa, Shigeo Morimoto, Katsuo Hatayama
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Patent number: 5602239Abstract: A novel macloride antibiotic having a potent antibacterial activity, represented by the formula: ##STR1## which is obtained by introducing a specific aryloxy or alkoxy group into the 3-position of a 5-O-desosaminylerythronolide derivative; or phamaceutically acceptable acid addition salts thereof.Type: GrantFiled: July 13, 1995Date of Patent: February 11, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yoko Misawa, Toshifumi Asaka, Masato Kashimura, Shigeo Morimoto, Katsuo Hatayama
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Patent number: 5597921Abstract: Indolo[2,3-b]quinoxaline derivatives represented by the following formula: ##STR1## wherein one of R.sup.1 and R.sup.2 is a hydrogen atom and the other is a group of the formula:--CH.sub.2 NHCCH.sub.3 (CH.sub.2 OH).sub.2,etc, and R.sup.3 is a hydrogen atom, a methyl group, etc.; and pharmaceutically acceptable salts thereof have an antitumor activity and are useful as medicines.Type: GrantFiled: October 16, 1995Date of Patent: January 28, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Taro Matsumoto, Hisaya Wada, Yoshihiro Migita, Katsuo Hatayama, Yoshinori Sekiguchi
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Patent number: 5591837Abstract: Object: To provide a novel macrolide antibiotic having a strong antibacterial activity.Constitution: 11-Amino-3,11-dideoxy-3-oxo-5-O-desosaminyl-6-O-methylerythronolide A 11-N,12-O-cyclic carbamate which has a ketone at the 3-position and a methylated hydroxyl group at the 6-position of a 5-O-desosaminylerythronolide A derivative, and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: October 14, 1994Date of Patent: January 7, 1997Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshifumi Asaka, Masato Kashimura, Yoko Misawa, Shigeo Morimoto, Katsuo Hatayama
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Patent number: 5571820Abstract: Endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1 -isopropyl-2(1H)-quinolone-3-carboxamide shown by formula (I): ##STR1## or an acid addition salt thereof exhibits a potent action for stimulating a serotonin 4 receptor and is effective for the treatment of diseases and for the improvement of conditions, caused by a reduced motility in the gastrointestinal tract.Type: GrantFiled: April 28, 1995Date of Patent: November 5, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Yutaka Ohuchi, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Katsuo Hatayama, Yoshihiko Isobe, Chika Ito, Makoto Muramatsu
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Patent number: 5523399Abstract: Provision of novel macrolide antibiotics having a strong antibacterial activity.Construction:Compounds represented by the formula: ##STR1## which are obtained by introducing a carbamoyl group into 5-O-desosaminyl-6-O-methylerythronolide derivatives at the 3-position; and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: June 20, 1994Date of Patent: June 4, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshifumi Asaka, Yoko Misawa, Masato Kashimura, Shigeo Morimoto, Katsuo Hatayama
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Patent number: 5521311Abstract: The present compounds represented by the formula: ##STR1## (wherein R.sup.1 is a phenyl group, a halophenyl group or a cycloalkyl group having 3 to 8 carbon atoms, R.sup.2 is a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, R.sup.3 is a hydrogen atom, an alkyl group having 1 to 7 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 3 to 5 carbon atoms or a benzyl group, or R.sup.2 and R.sup.3 are bonded together to form a 5- to 7-membered heterocycle) and salts thereof have potent anti-inflammatory, antipyretic, analgesic and anti-allergic actions with less side effects such as gastrointestinal disorders and with such a high safety as to permit long-term administration.Type: GrantFiled: August 14, 1995Date of Patent: May 28, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Shiuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama
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Patent number: 5502202Abstract: Object: To provide an antipsychotic drug being different in functional mechanism from dopamine autoreceptor agonists, namely, to provide an antipsychotic drug having a specific affinity for a sigma receptor and causing no extrapyramidal disorder.Constitution: An aminoalkylthiazole derivative represented by formula: ##STR1## (wherein R.sup.1 represents a phenyl group substituted with a halogen atom; R.sup.2 and R.sup.3 are either the same or different and each represents an alkyl group having 4 to 10 carbon atoms; and n is 2 or 3;) and a salt thereof.Type: GrantFiled: November 29, 1993Date of Patent: March 26, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Yoshinori Sekiguchi, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5496829Abstract: 2-nitroxyethyl (+)apovincaminate is used as an agent for relieving disturbance of consciousness and as a narcotic antagonist.Type: GrantFiled: May 24, 1994Date of Patent: March 5, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Shigeru Okuyama, Susumu Otomo, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5495046Abstract: An alkoxyphenylalkylamine derivative represented by the following formula: ##STR1## (wherein X.sup.1 and X.sup.2 may be either the same or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkoxy group having 1 to 5 carbon atoms and substituted with a phenyl group; R.sup.1 and R.sup.2 may be either the same or different from each other and each represents a hydrogen atom, an alkyl group having 1 to 7 carbon atoms, an alkyl group having 1 to 7 carbon atoms and substituted with "a hydroxyl group, a carboxyl group or an alkoxycarbonyl group" at the end, or, R.sup.1 and R.sup.Type: GrantFiled: March 31, 1994Date of Patent: February 27, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Yoshinori Sekiguchi, Koumei Ohta, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5478945Abstract: A thiazoline derivative represented by the formula: ##STR1## [wherein R.sup.1 is cyano, carbamoyl, thiocarbamoyl, morpholinothiocarbonyl, alkylthioimidoyl, amidino, substituted amidino or imidazolin-2-yl, R.sup.2 is alkyl or aralkyl, R.sup.3 is hydrogen or alkyl, R.sup.4 is hydroxyl, alkoxy, substituted alkoxy or amino, l is an integer of 1 to 5] and salts thereof have fibrinogen receptor antagonism and cell adhesion factor antagonism, and are useful as therapeutic agents for ischemic diseases and atherosclerosis diseases, and metastasis inhibitory agents of tumors.Type: GrantFiled: January 11, 1995Date of Patent: December 26, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Akira Manaka, Keiko Takahashi, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5475130Abstract: An anilide derivative useful as an atherosclerosis treating drug, represented by the following formula (I): ##STR1## wherein X is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; Y is a hydrogen atom or an alkoxy group having 1 to 4 carbon atoms; Z is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; A is an alkylene group having 1 to 4 carbon atoms; R is an alkyl group having 6 to 20 carbon atoms, an alkanoyl group having 2 to 20 carbon atoms or a benzyl group which may be substituted with an alkyl group having 1 to 4 carbon atoms; and n is 0, 1 or 2.Type: GrantFiled: May 25, 1993Date of Patent: December 12, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5449826Abstract: To provide an excellent compound having anti-inflammatory, antipyretic, analgesic and antirheumatic actions.A 5-amino-2-phenoxysulfonanilide compound represented by the formula: ##STR1## and the salts thereof have potent anti-inflammatory, antipyretic, analgesic and antirheumatic actions, and therefore they are useful as anti-inflammatory, antipyretic, analgesic and antirheumatic agents.Type: GrantFiled: December 9, 1994Date of Patent: September 12, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Shuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama
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Patent number: 5416212Abstract: An anilide compound represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent an alkyl group having 1 to 4 carbon atoms; n represents 0, 1 or 2; A represents an alkylene group having 1 to 14 carbon atoms or a group represented by --CH.sub.2 CO--; and Ar represents a phenyl group, a phenyl group substituted with a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an alkanoyl group having 2 to 5 carbon atoms or a trifluoromethyl group, a benzyl group, a pyridyl group, a pyridyl group substituted with a halogen atom or a trifluoromethyl group, or a pyrimidyl group, or a salt thereof. The disclosed anilide compounds have potent ACAT inhibitory activity.Type: GrantFiled: June 20, 1994Date of Patent: May 16, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Masakazu Sato, Masahiro Kawase, Akira Manaka, Yutaka Kawashima, Katsuo Hatayama