Patents by Inventor Katsuo Komiya

Katsuo Komiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9028683
    Abstract: To provide a medium suitable for high speed/high resolution, rich in hydrophilicity and resistant to a high concentration aqueous alkaline solution. A medium comprising crosslinked polymer particles containing from 20 to 95 mol % of repeating units derived from a (meth)acryloyl monomer represented by the formula (1): wherein R2 is a hydrogen atom or a C1-4 alkyl group, R1 is —NR3-R4-R5 or —O—R4-R5, R3 is a hydrogen atom or a C1-4 alkyl group, R4 is a C6-15 alkylene group containing an alicyclic ring or a C4-8 linear alkylene group, and R5 is a halogen atom, an alcoholic OH group, an amino group, a glycidyl group or an epoxy group.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: May 12, 2015
    Assignee: Tosoh Corporation
    Inventors: Katsuo Komiya, Yuji Kubo, Sanae Hasegawa
  • Publication number: 20130253142
    Abstract: A novel separating agent for protein purification which not only can adsorb proteins in a sufficient amount for protein purification from a low concentration buffer but also can desorb the adsorbed protein easily just by altering the pH of the buffer and a simple and economical method for its production and a method for protein purification using it. One or two ligands selected from the group consisting of a ligand represented by the following formula (1): (wherein m is an integer of from 2 to 6) and a ligand represented by the following formula (2): (wherein each of R1 and R2 is independently a hydrogen atom or a C1-4 alkyl group, and n is an integer of from 1 to 6) are immobilized on a support via a urethane bond without intervention of a spacer arm.
    Type: Application
    Filed: May 17, 2013
    Publication date: September 26, 2013
    Applicant: TOSOH CORPORATION
    Inventors: Seiji MASUMOTO, Katsuo KOMIYA, Koji NAKAMURA
  • Patent number: 8530698
    Abstract: A packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved. Separation and purification, or collection and recovery, of a biopolymer, is carried out by liquid chromatography by means of a packing material for liquid chromatography comprising a base matrix and a ligand immobilized to the base matrix, wherein the base matrix is a hydrophilic base matrix having alcoholic hydroxy groups on its surface, the ligand is at least one ligand selected from the group consisting of an ?-amino acid which is immobilized to the base matrix by an amide bond or an urethane bond via the amino group contained in the ?-amino acid.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: September 10, 2013
    Assignee: Tosoh Corporation
    Inventors: Katsuo Komiya, Koji Nakamura
  • Publication number: 20110105736
    Abstract: A novel separating agent for protein purification which not only can adsorb proteins in a sufficient amount for protein purification from a low concentration buffer but also can desorb the adsorbed protein easily just by altering the pH of the buffer and a simple and economical method for its production and a method for protein purification using it. One or two ligands selected from the group consisting of a ligand represented by the following formula (1): (wherein m is an integer of from 2 to 6) and a ligand represented by the following formula (2): (wherein each of R1 and R2 is independently a hydrogen atom or a C1-4 alkyl group, and n is an integer of from 1 to 6) are immobilized on a support via a urethane bond without intervention of a spacer arm.
    Type: Application
    Filed: June 22, 2009
    Publication date: May 5, 2011
    Applicant: TOSOH CORPORATION
    Inventors: Seiji Masumoto, Katsuo Komiya, Koji Nakamura
  • Publication number: 20100160605
    Abstract: To provide a novel packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved, and to provide a process for concentrating and recovering a desired biopolymer such as a protein or a peptide from a large amount of dilute cell culture solution by means of such a packing material.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 24, 2010
    Applicant: TOSOH CORPORATION
    Inventors: Katsuo KOMIYA, Koji NAKAMURA
  • Publication number: 20100029914
    Abstract: To provide a medium suitable for high speed/high resolution, rich in hydrophilicity and resistant to a high concentration aqueous alkaline solution. A medium comprising crosslinked polymer particles containing from 20 to 95 mol % of repeating units derived from a (meth)acryloyl monomer represented by the formula (1): wherein R2 is a hydrogen atom or a C1-4 alkyl group, R1 is —NR3—R4-R5 or —O—R4-R5, R3 is a hydrogen atom or a C1-4 alkyl group, R4 is a C6-15 alkylene group containing an alicyclic ring or a C4-8 linear alkylene group, and R5 is a halogen atom, an alcoholic OH group, an amino group, a glycidyl group or an epoxy group.
    Type: Application
    Filed: June 8, 2006
    Publication date: February 4, 2010
    Applicant: TOSOH CORPORATION
    Inventors: Katsuo Komiya, Yuji Kubo, Masazumi Hasegawa, Sanae Hasegawa
  • Patent number: 6900157
    Abstract: A process for production of a partially hydrophilized absorbent is described, which comprises using, as a starting material, porous particles made of an organic compound having properties such that they are shrunk in a solvent containing water as a major component and swollen in a solvent containing an organic solvent as a major component; newly introducing functional groups to react with any one compound selected from the group consisting of compounds containing hydroxyl, amino, carboxyl, halogen or epoxy group in a solvent containing an organic solvent as a major component; and then reacting with a compound containing alcoholic OH group in a solvent containing water as a major component to immobilize the compound containing alcoholic OH group on the outer surfaces of the particles.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: May 31, 2005
    Assignee: Tosoh Corporation
    Inventors: Koji Nakamura, Katsuo Komiya, Satoshi Fujii
  • Publication number: 20030050403
    Abstract: A process for production of a partially hydrophilized absorbent is described, which comprises using, as a starting material, porous particles made of an organic compound having properties such that they are shrunk in a solvent containing water as a major component and swollen in a solvent containing an organic solvent as a major component; newly introducing functional groups to react with any one compound selected from the group consisting of compounds containing hydroxyl, amino, carboxyl, halogen or epoxy group in a solvent containing an organic solvent as a major component; and then reacting with a compound containing alcoholic OH group in a solvent containing water as a major component to immobilize the compound containing alcoholic OH group on the outer surfaces of the particles.
    Type: Application
    Filed: September 9, 2002
    Publication date: March 13, 2003
    Applicant: TOSOH CORPORATION
    Inventors: Koji Nakamura, Katsuo Komiya, Satoshi Fujii
  • Patent number: 5504068
    Abstract: A topical preparation containing cyclosporin as an active ingredient, is disclosed that contains (a) cyclosporin; (b) an organic solvent for dissolving the cyclosporin; (c) an ester of a fatty acid with a monovalent alcohol having a total number of carbon atoms of 8 or more and/or an alkanol amine, each being in liquid state at 25.degree.C; (d) an oily substance in solid state at 25.degree.C; and (e) a surfactant. The cyclosporin is present in a concentration ranging from appoximately 0.1% to 10% by weight and the ester and/or alkanol amine are/is present in a concentration ranging from approximately 1% to 15% by weight. The topical preparations are active against atopic dermatitis, psoriasis and allergic contact dermatitis.
    Type: Grant
    Filed: February 23, 1993
    Date of Patent: April 2, 1996
    Assignee: LTT Institute Co., Ltd.
    Inventors: Katsuo Komiya, Rie Igarashi, Mitsuko Takenaga, Akira Yanagawa, Yutaka Mizushima, Tateo Nishimura, Toshitaka Kudo, Kunio Ando
  • Patent number: 5447624
    Abstract: A microspherical packing for liquid chromatography, which comprises a porous silicon carbide having numerous through-pores, and a process for producing said microspherical packing.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: September 5, 1995
    Assignees: Nippon Carbon Co., Ltd., Tosoh Corporation
    Inventors: Takanobu Kawai, Hiroshi Wakizaka, Hiroyuki Moriyama, Katsuo Komiya, Hiroshi Ichikawa, Akira Yokoyama
  • Patent number: 5438077
    Abstract: An ion exchanger comprising a particle of an insoluble crosslinked polymer having alcoholic hydroxyl groups, as a base material, and a glycidyl-adduct of polyol and/or its oligomer, as a spacer, wherein ion exchange groups are attached to the spacer.
    Type: Grant
    Filed: January 19, 1994
    Date of Patent: August 1, 1995
    Assignee: Toson Corporation
    Inventors: Katsuo Komiya, Toshikuni Koga, Yoshio Kato
  • Patent number: 5270280
    Abstract: A packing material for liquid chromatography is produced by mixing 1.0 part by weight of carbon black, 0.5 to 2.5 parts by weight of one or a mixture of a synthetic resin which can be graphitized by heating and a toluene- or benzene-soluble component of pitches, and an organic solvent to obtain a mixture. The carbon black has a particle diameter of 12 to 40 nm, a specific surface area of 50 to 650 m.sup.2 /g, a DBP oil absorption amount of 50 to 150 ml/100 g. The synthetic resin is one selected from phenol resin, furan resin, furfural resin, divinylbenzene resin and urea resin. The pitches are ones selected from petroleum pitches, coal-tar pitches and liquefied coal oil. The mixture is granulated by spray granulation or emulsion granulation to obtain granules whose ratio L.sub.min /L.sub.max of a minor axis diameter L.sub.min to a major axis diameter L.sub.max is 0.90 to 1.0. The heat treatment of the granules is also made in an inert gas under pressure.
    Type: Grant
    Filed: October 30, 1991
    Date of Patent: December 14, 1993
    Assignees: Nippon Carbon Co., Ltd., Tosoh Corporation
    Inventors: Hiroshi Ichikawa, Akira Yokoyama, Takanobu Kawai, Hiroyuki Moriyama, Katsuo Komiya, Yoshio Kato
  • Patent number: 5194333
    Abstract: A packing material for reversed phase chromatography, which comprises silica gel with its entire surface substantially coated with repeating units of a polycarbosilane of the formula (I): ##STR1## wherein R.sub.1 is an octyl group, an octadecyl group or a phenyl group, R.sub.2 is a methyl group or a methylene group, and n is a positive integer.
    Type: Grant
    Filed: December 18, 1990
    Date of Patent: March 16, 1993
    Assignee: Tosoh Corporation
    Inventors: Tadao Ohnaka, Katsuo Komiya, Hiroyuki Moriyama
  • Patent number: 5178854
    Abstract: A method for lowering serum total cholesterol in an animal by administering to the aminal an anion-exchange resin having the monomer units respectively represented by the below-given structural formulas (I), (II), (III) and (IV) in a content of 60-95 molar % of the monomer unit (I), 0-25 molar % of the monomer unit (II), 0--30 molar % of the monomer unit (III) and 1-6 molar % of themonomer unit (IV). ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different respectively are hydrogen atom, a lower alkyl group or benzyl group, R.sup.4 is hydrogen atom, a lower alkyl group or hydroxy-methyl group and X is a halogen atom. The above-mentioned agents specifically bind with bile acid in the intestinal tract even in the presence of other acids.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: January 12, 1993
    Assignees: Taisho Pharmaceutical Co., Ltd., Tosoh Corporation
    Inventors: Yumiko Asami, Katsuo Komiya, Hiroo Sasaki, Hironaka Aihara
  • Patent number: 5177232
    Abstract: A method for chemically modifying an anionic metal complex, by obtaining from an anionic metal complex insoluble in a non-aqueous solvent and a clathrate compound a clathrate complex thereof with a counter cation of said metal complex, which is soluble in a non-aqueous solvent, and then reacting functional groups of the metal complex, which are not concerned with the coordination of said metal complex, with an organic reagent in the presence of a reaction assistant.The central metal from the chemically modified metal complex may then be removed.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: January 5, 1993
    Assignee: Tosoh Corporation
    Inventors: Mitsunobu Sato, Shigenobu Yano, Ryuichi Kitayama, Katsuo Komiya
  • Patent number: 5061816
    Abstract: A method for chemically modifying an anionic metal complex, by obtaining from an anionic metal complex, insoluble in a non-aqueous solvent and a clathrate compound a clathrate complex thereof with a counter cation of said metal complex, which is soluble in a non-aqueous solvent, and then reacting functional groups of the metal complex, which are not concerned with the coordination of said metal complex, with an organic reagent in the presence of a reaction assistant.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: October 29, 1991
    Assignee: Tosoh Corporation
    Inventors: Mitsunobu Sato, Shigenobu Yano, Ryuichi Kitayama, Katsuo Komiya
  • Patent number: 4835058
    Abstract: A packing material for chromatography comprising a carrier having silanol groups on its surface, wherein Si in the silanol groups forms a Si--O--Si bond together with Si in a silyl group of the following formula I and Si in a silyl group of the following formula II, and the molar ratio of the silyl group of the formula II is from 0 to 2/3 based on the total amount of silyl groups: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydroxyl group, a methyl group, an ethyl group, an alkoxy group having from 1 to 3 carbon atoms, a phenoxy group, an acetoxy group, a trimethylsiloxy group, a triethylsiloxy group or an oxygen atom bonded to Si in a silanol group on the surface of the carrier, R.sub.3 is a 3-carbonyloxypropyl group, a 1-phenyleneethyl group or a 2-phenyleneethyl group, R.sub.4 is a hydrogen atom or a methyl group, and each of m and n is an integer of at least 1; and ##STR2## wherein each of R.sup.1 and R.sup.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: May 30, 1989
    Assignee: Tosoh Corporation
    Inventors: Katsuo Komiya, Yoshio Kato
  • Patent number: 4830921
    Abstract: A packing material for liquid chromatography, which comprises an optically active compound having the formula: ##STR1## wherein Ar is a phenyl group, an .alpha.-naphthyl group or a .beta.-naphthyl group, R.sub.1 is an alkyl group having from 1 to 4 carbon atoms, a phenyl group or a 3,5-dinitrophenyl group, R.sub.2 is an alkyl group having from 1 to 4 carbon atoms, *indicates an asymmetric carbon atom and n is an integer of 2 or 3, as a stationary phase.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: May 16, 1989
    Assignee: Tosoh Corporation
    Inventors: Ryuichi Kitayama, Katsuo Komiya, Yoshio Kato
  • Patent number: 4256842
    Abstract: A hydrophilic separating carrier is a porous spherical gel having primary hydroxyl groups and is produced by an aqueous suspension homopolymerization of pentaerythritol dimethacrylate or an aqueous suspension copolymerization of pentaerythritol dimethacrylate and a methacrylate monomer having hydrophilic group and/or hydrophilic convertible group.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: March 17, 1981
    Assignee: Toyo Soda Manufacturing Company, Limited
    Inventors: Hiroo Sasaki, Katsuo Komiya, Yoshio Kato
  • Patent number: 4256843
    Abstract: A hydrophilic separating carrier is a porous spherical gel having primary hydroxyl groups and is produced by an aqueous suspension homopolymerization of pentaerythritol dimethacrylate or an aqueous suspension copolymerization of pentaerythritol dimethacrylate and a methacrylate monomer having hydrophilic group and/or hydrophilic convertible group.
    Type: Grant
    Filed: March 7, 1980
    Date of Patent: March 17, 1981
    Assignee: Toyo Soda Manufacturing Company, Limited
    Inventors: Hiroo Sasaki, Katsuo Komiya, Yoshio Kato