Patents by Inventor Katsuyoshi Hara

Katsuyoshi Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof
    Patent number: 10822354
    Abstract: The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2,3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, which uses a salt of an organic acid and (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid benzyl.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: November 3, 2020
    Assignee: Japan Tobacco Inc.
    Inventors: Takahiro Yamasaki, Yoshinori Hara, Takayuki Sakai, Kengo Murakami, Katsuyoshi Hara, Naoki Manta
  • Method for Producing 7h-pyrrolo[2, 3-d]pyrimidine Derivative and Intermediate Thereof
    Publication number: 20190062346
    Abstract: The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2,3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, which uses a salt of an organic acid and (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid benzyl.
    Type: Application
    Filed: July 6, 2016
    Publication date: February 28, 2019
    Inventors: Takahiro Yamasaki, Yoshinori Hara, Takayuki Sakai, Kengo Murakami, Katsuyoshi Hara, Naoki Manta
  • Process for producing acetophenone compound
    Patent number: 6498276
    Abstract: The present invention relates to a method for producing a compound of the formula [71] wherein R1 is an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group, R2 is a lower alkyl or a halogenated lower alkyl and R3 is a halogen atom or a hydrogen atom. The method of the present invention includes reacting compound [1] with thionyl chloride to give compound [2] and obtaining the objective compound [7] at a high yield via intermediate [5], and is utilizable for industrial production.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: December 24, 2002
    Assignee: Japan Tobacco Inc.
    Inventors: Koji Matsuda, Katsuyoshi Hara, Minoru Akamatsu
  • Process for producing acetophenone compound
    Publication number: 20020072613
    Abstract: The present invention relates to a method for producing a compound of the formula [7] 1
    Type: Application
    Filed: February 6, 2002
    Publication date: June 13, 2002
    Applicant: Japan Tobacco Inc.
    Inventors: Koji Matsuda, Katsuyoshi Hara, Minoru Akamatsu
  • Process for producing oxazole compound
    Patent number: 6372915
    Abstract: The present invention relates to a method for producing a compound of the formula [7] wherein R1 is an optionally substituted cycloalkyl group, an optionally substituted aryl group or an optionally substituted heterocyclic group, R2 is a lower alkyl or a halogenated lower alkyl and R3 is a halogen atom or a hydrogen atom. The method of the present invention includes reacting compound [1] with thionyl chloride to give compound [2] and obtaining the objective compound [7] at a high yield via intermediate [5], and is utilizable for industrial production.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: April 16, 2002
    Assignee: Japan Tobacco Inc.
    Inventors: Koji Matsuda, Katsuyoshi Hara, Minoru Akamatsu
  • Cyclohexene derivative and method of producing the same
    Patent number: 5329042
    Abstract: Provided is a novel (1R, 2S)-1-acyl-2-carboxycyclohex-4-ene derivative represented by the following general formula [I], and its producing method, ##STR1## (where R.sup.1 represents a hydrogen atom, a lower alkyl group, or substituted or unsubstituted aryl group, and R.sup.2 represents a hydrogen atom, or a lower alkyl group). Also provided is a method of producing a (3S, 4R)-4-substituted-3-carboxycyclopentanone derivative represented by the following general formula [A], ##STR2## (where R.sup.1 and R.sup.2 are the same as those mentioned above).
    Type: Grant
    Filed: December 24, 1992
    Date of Patent: July 12, 1994
    Assignee: Japan Tobacco Inc.
    Inventors: Junichi Haruta, Kazuhiko Sakuma, Akihiro Yasuda, Katsuyoshi Hara, Itsuo Uchida
  • Histidyl peptide derivatives
    Patent number: 5151497
    Abstract: Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof.Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: September 29, 1992
    Assignees: Japan Tobacco Inc., Yoshotomi Pharmaceutical Industries, Ltd.
    Inventors: Itsuo Uchida, Akira Saito, Akihiro Yasuda, Kunio Iwata, Hiroaki Hari, Katsuyoshi Hara, Mutsuyoshi Matsushita, Koretake Anami, Junichi Haruta, Noboru Furukawa