Patents by Inventor Katsuyuki Tanizawa

Katsuyuki Tanizawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7951379
    Abstract: The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein that has been modified to lack its infectivity to hepatocytes and display an antibody). The particle surface of the drug displays an antibody, such as a cancer specific antibody, that recognizes an antigen molecule displayed on the surface of a specific cancer cell.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: May 31, 2011
    Assignees: Japan Science and Technology Agency, Beacle, Inc.
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Toshihide Okajima, Akihiko Kondo, Masakazu Ueda, Masaharu Seno
  • Patent number: 7597905
    Abstract: As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a protein capable of forming particles (e.g., hepatitis B virus surface antigen protein), and a biorecognition molecule introduced therein, are provided.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: October 6, 2009
    Assignee: Beacle Inc.
    Inventors: Shun'ichi Kuroda, Katsuyuki Tanizawa, Masaharu Seno, Akihiko Kondo, Masakazu Ueda
  • Publication number: 20090011036
    Abstract: The subject invention provides a disease-treating drug that uses hollow protein nanoparticles to specifically act on a target cell or tissue. The present invention allows a protein drug to be effectively capsulated in the particles. The invention also provides a therapeutic method using such a drug. The drug according to the present invention is capable of recognizing a specific cell, such as hepatocytes, and manufactured by fusing a disease-treating substance for a target cell (for example, interferon, hepatocyte growth factor etc.) with hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein).
    Type: Application
    Filed: November 30, 2007
    Publication date: January 8, 2009
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Hiroko Tada
  • Publication number: 20070218453
    Abstract: This invention relates to a hollow-nanoparticle-based biosensing tool, which comprises proteins capable of forming nanoparticles through the incorporation of a lipid bilayer and specific biorecognition molecules bound thereto and a biosensing method using such tool.
    Type: Application
    Filed: March 29, 2005
    Publication date: September 20, 2007
    Inventors: Katsuyuki Tanizawa, Shun'ichi Kuroda, Giman Jung, Hideo Akiyama, Hitoshi Nobumasa
  • Publication number: 20070135365
    Abstract: Compositions and methods for preventing or treating cardiac hypertrophy which inhibit the cardiac hypertrophy signal pathway mediated through G protein coupled receptors (GPCR) or epidermal growth factor (EGF) receptors. The present invention also relates to methods for screening active ingredients, and to animal models of cardiac hypertrophy.
    Type: Application
    Filed: August 20, 2004
    Publication date: June 14, 2007
    Inventors: Katsuyuki Tanizawa, Miki Iwata, Shun'ichi Kuroda
  • Publication number: 20060292118
    Abstract: The subject invention is hollow nanoparticles that comprise particle-forming first proteins (e.g. hepatitis B virus surface-antigen protein), containing a bio-recognizing molecule for recognizing a specific cell, wherein at least one of the first proteins interacts with a second protein (e.g. hepatitis B virus core-antigen protein) forming a capsid structure. With this structure, the present invention provides hollow nanoparticles, that allow transfer of a substance to a specific cell or tissue, and can be manufactured with stable productivity. The present invention further provides a drug made of the hollow nanoparticles.
    Type: Application
    Filed: November 25, 2003
    Publication date: December 28, 2006
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno
  • Publication number: 20060240114
    Abstract: A therapeutic product or drug for therapy of hemophilia may be produced by a simplified method including embedding genes of the blood clotting factors VIII (IX) for therapy of hemophilia in hollow nano particles obtained on expressing the protein having a particle forming function, such as hepatitis B virus surface antigen protein, in eucaryotic cells. The drug so produced is able to introduce the genes of the blood clotting factors efficaciously into liver cells with the least risk of side effects.
    Type: Application
    Filed: March 17, 2004
    Publication date: October 26, 2006
    Inventors: Masakazu Ueda, Shunichi Kuroda, Katsuyuki Tanizawa, Masaharu Senoo, Akihiko Kondo, Thierry Vandendriessche, Maurinee Chuah
  • Publication number: 20060165726
    Abstract: The invention provides a disease-treating drug, specifically acting particular cells or tissues, which is based on protein hollow nanoparticles. The drug's therapeutic effects are confirmed through animal experiments. The invention also provides a treatment method using the drug. The disease-treating drug comprises a substance to be transferred into a cell for treatment of a disease (for example, cancer-treating, thymidine kinase gene of herpes simplex virus type 1) encapsulated in hollow nanoparticles containing particle-forming protein (for example, hepatitis B virus surface antigen protein modified to lose infectivity to inherent hepatocyte and also display a growth factor) displaying, for example, a growth factor.
    Type: Application
    Filed: March 5, 2003
    Publication date: July 27, 2006
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Hidehiko Iwabuki
  • Publication number: 20060141042
    Abstract: The invention provides hollow nanoparticles of a protein with the ability to recognize specific cells such as the hepatocytes and to form particles (for example, hepatitis B virus surface-antigen protein), wherein the protein has a cysteine residue substituted to a different amino acid. The hollow nanoparticles have a stable particle structure and can be used to efficiently transfer substances to specific target cells or tissues. The invention also provides a drug using the hollow nanoparticles.
    Type: Application
    Filed: June 27, 2003
    Publication date: June 29, 2006
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Hiroko Tada
  • Publication number: 20060107338
    Abstract: The present invention provides a cirrhosis model animal having human hepatic tissues affected with cirrhosis. Anti-asialo GM1 antibodies are administered to a scid mouse which is an immune-deficiency animal, and its natural-killer-cell-dependent immune response capability is made defective, and then cirrhosis-patient-derived hepatic tissues are transplanted beneath a kidney membrane of the scid mouse, thereby producing the cirrhosis model animal. The cirrhosis model animal has the human hepatic tissues affected with cirrhosis, so that it is possible to use the cirrhosis model animal in development of a therapy and a therapeutic drug for cirrhosis.
    Type: Application
    Filed: July 14, 2003
    Publication date: May 18, 2006
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno
  • Publication number: 20060088536
    Abstract: The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein that has been modified to lack its infectivity to hepatocytes and display an antibody). The particle surface of the drug displays an antibody, such as a cancer specific antibody, that recognizes an antigen molecule displayed on the surface of a specific cancer cell.
    Type: Application
    Filed: March 26, 2003
    Publication date: April 27, 2006
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Toshihide Okajima, Akihiko Kondo, Masakazu Ueda, Masaharu Seno
  • Publication number: 20060034869
    Abstract: The invention provides a drug for treating hepatic diseases with the use of hollow protein nanoparticles. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a hepatic disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles that have an ability to recognize a hepatocyte and are composed of a particle-forming protein (for example, hepatitis B virus surface-antigen protein).
    Type: Application
    Filed: March 5, 2003
    Publication date: February 16, 2006
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Hidehiko Iwabuki
  • Publication number: 20060002901
    Abstract: A therapeutic composition for a disease caused by a failure in the survival, proliferation and/or differentiation of a cell which contains eosinophil cationic protein and other components; and a medium composition for promoting the survival, proliferation and/or differentiation of a cell.
    Type: Application
    Filed: October 2, 2003
    Publication date: January 5, 2006
    Inventors: Masaharu Seno, Shun'ichi Kuroda, Katsuyuki Tanizawa, Midori Kitazoe, Miki Iwata, Toshitsugu Fujita, Nobuyuki Bokui
  • Publication number: 20050181064
    Abstract: The subject invention provides a disease-treating drug that uses hollow protein nanoparticles to specifically act on a target cell or tissue. The present invention allows a protein drug to be effectively capsulated in the particles. The invention also provides a therapeutic method using such a drug. The drug according to the present invention is capable of recognizing a specific cell, such as hepatocytes, and manufactured by fusing a disease-treating substance for a target cell (for example, interferon, hepatocyte growth factor etc.) with hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein).
    Type: Application
    Filed: March 5, 2003
    Publication date: August 18, 2005
    Applicant: Japan Science and Technology Agency
    Inventors: Shunichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Masaharu Seno, Hiroko Tada
  • Publication number: 20030092069
    Abstract: As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a protein capable of forming particles (e.g., hepatitis B virus surface antigen protein), and a biorecognition molecule introduced therein, are provided.
    Type: Application
    Filed: October 8, 2002
    Publication date: May 15, 2003
    Inventors: Shun?apos;ichi Kuroda, Katsuyuki Tanizawa, Masaharu Seno, Akihiko Kondo, Masakazu Ueda