Abstract: A variable length field FC address system includes a source device coupled to a target device via an FC fabric. A first FC switch device identifies a number of FC switch devices in the FC fabric, a number of links provided by each FC switch device, a number of sessions required by each link, and then allocates unique FC addresses to the FC switch devices. Each unique FC address associated with an FC switch device includes a domain identifier provided by a first number of bits based on the number of FC switch devices in the FC fabric, an area identifier provided by a second number of bits based on the number of links provided by that FC switch device, and a session identifier provided by a third number of bits based on the number of sessions required by the link provided by that FC switch device.

Abstract: Described herein are methods and compositions useful for inducing maturation of a cardiomyocyte to a mature (e.g., adult) phenotype, such that the function and morphology of the mature cardiomyocyte matches or more closely mimics that of the adult heart. The methods and compositions use Let-7 miRNAs and modified forms thereof. Such methods and compositions permit the study and treatment of adult-onset cardiac diseases, disorders or injuries with mature cardiomyocytes that mimic the heart function of an adult. Methods of using cardiomyocytes matured in this manner for drug identification and drug cardiotoxicity testing are also provided.

Abstract: Described herein are methods and compositions useful for inducing maturation of a cardiomyocyte to a mature (e.g., adult) phenotype, such that the function and morphology of the mature cardiomyocyte matches or more closely mimics that of the adult heart. The methods and compositions use Let-7 miRNAs and modified forms thereof. Such methods and compositions permit the study and treatment of adult-onset cardiac diseases, disorders or injuries with mature cardiomyocytes that mimic the heart function of an adult. Methods of using cardiomyocytes matured in this manner for drug identification and drug cardiotoxicity testing are also provided.