Abstract: Provided are an electronic drive device and an electronic steering device, in each of which: a mounting substrate has one surface as a first surface on which a first heat generating component is mounted and the other surface as a second surface on which a second heat generating component is mounted; a first heat dissipation member is arranged in contact with the second surface at a position corresponding to a mounted position of the first heat generating component such that heat generated by the first heat generating component is dissipated to a motor housing; and a second heat dissipation member is arranged in contact with the first surface at a position corresponding to a mounted position of the second heat generating component such that heat generated by the second heat generating component is dissipated to a cover.

Abstract: A first circuit board 16 and a second circuit board 17, each of which have mounted thereon circuit components for controlling and driving an electric motor, are stacked with a space left therebetween such that one board surface of the first circuit board and one board surface of the second circuit board are opposed to and face each other in the direction of a rotation shaft 14 of the electric motor. In a state that the first circuit board 16 and the second circuit board 17 are attached to the motor housing, a receptacle connector 28 mounted on the first circuit board and a plug connector 34 mounted on the second circuit board form a “board-to-board connector” by which the circuit components of the first and second circuit boards are electrically connected.

Abstract: The device has motor housing side annular engagement portion 40 formed at outer circumferential surface of end surface portion of motor housing 11 which is opposite side to output shaft portion of rotation shaft of electric motor; and metal cover side annular engagement portion 38 formed at opening end 37 of metal cover 12 that covers electronic control unit and engaged with motor housing side annular engagement portion 40. Fixing region is formed by fixing metal cover side annular engagement portion 38 to motor housing side annular engagement portion 40 in a fixing manner without using any fixing screw in a state in which metal cover side annular engagement portion 38 is engaged with motor housing side annular engagement portion 40. Sealing region is formed between fixing region and opening end 37 of the metal cover 12 with liquid sealant 41 applied between fixing region and opening end 37.

Abstract: In some embodiments, the present disclosure relates to mutated tRNAs in which the first letter of the anticodon has been substituted to lysidine or agmatidine, and translation systems containing the mutated tRNAs. In a specific embodiment, the present disclosure provides mutated tRNAs capable of selectively translating codon NNA. In another embodiment, the present disclosure provides translation systems capable of translating two or three types of amino acids from a single codon box. In still another embodiment, the present disclosure provides novel methods for synthesizing lysidine diphosphate, agmatidine diphosphate, and derivatives thereof.

Abstract: On the opposite side to an output of a rotation shaft of an electric motor, a ventilation hole communicating between an electronic control unit (ECU) housing space and an electric motor housing space is formed to an end surface wall of a motor housing separating the respective housing spaces. The ventilation hole has a waterproof ventilation part that suppresses water passing but permits the passage of air and water vapor. This structure eliminated the influence of flying rocks and muddy water from the external environment, and suppresses for a long period of time the internal pressure fluctuation of the ECU housing space and the penetration of water into the housing space. Therefore, the internal pressure fluctuation of the housing space for the ECU and the penetration of water into the housing space for the ECU can be suppressed over a long period of time.

Abstract: A plurality of circuit boards (31), (34) are stacked at a side end wall (15), located an opposite side to an output shaft portion (14) of rotation shaft of electric motor, of a motor housing (11). Besides a circuit board fixing portion (26) for the one circuit board (34), heat-releasing member (38) that thermally connects one surface of the circuit board (34) and a metal cover (12) covering the circuit board (34) is provided between the one surface of the circuit board (34) and the metal cover (12). Besides connecting the circuit board (34) to the circuit board fixing portion (26), by thermally connecting the one surface of the circuit board (34) and the metal cover (12) through the heat-releasing member (38), it is possible to adequately release heat generated from a transistor, then influence of heat on electronic circuit element that is susceptible to heat can be suppressed.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: An element-side connection terminal (40) extending from a power conversion circuit unit (16) includes a first connection terminal portion (40A) that extends in a direction intersecting a direction of extension of a counterpart-side connection terminal (38); and a second connection terminal portion (40B) that is bent at a point before the first connection terminal portion (40A) reaches the counterpart-side connection terminal (38) in a direction to intersect the direction of extension of the counterpart-side connection terminal (38) such that the second connection terminal portion (40B) is provided with elasticity and is in an elastic contact with the counterpart-side connection terminal (38) at an angle. A tip end side (38T) of the counterpart-side connection terminal (38) and a tip end side (40T) of the second connection terminal portion (40B) are electrically joined.

Abstract: The device has motor housing side annular engagement portion 40 formed at outer circumferential surface of end surface portion of motor housing 11 which is opposite side to output shaft portion of rotation shaft of electric motor; and metal cover side annular engagement portion 38 formed at opening end 37 of metal cover 12 that covers electronic control unit and engaged with motor housing side annular engagement portion 40. Fixing region is formed by fixing metal cover side annular engagement portion 38 to motor housing side annular engagement portion 40 in a fixing manner without using any fixing screw in a state in which metal cover side annular engagement portion 38 is engaged with motor housing side annular engagement portion 40. Sealing region is formed between fixing region and opening end 37 of the metal cover 12 with liquid sealant 41 applied between fixing region and opening end 37.

Abstract: An electronic control device includes a relay including a relay case and an electromagnet and a contact part. The relay case is structured to contain the electromagnet and the contact part. The contact part is structured to be opened and closed by action of the electromagnet. A connector terminal is electrically connected to the relay. A circuit board is structured to mount the relay and the connector terminal thereon. An exterior shell is structured to contain the circuit board such that the connector terminal is exposed outside the exterior shell. A thermal mass element is disposed in a wiring route between the relay and the connector terminal.

Abstract: An electronic control device includes a relay including a relay case and an electromagnet and a contact part. The relay case is structured to contain the electromagnet and the contact part. The contact part is structured to be opened and closed by action of the electromagnet. A connector terminal is electrically connected to the relay. A circuit board is structured to mount the relay and the connector terminal thereon. An exterior shell is structured to contain the circuit board such that the connector terminal is exposed outside the exterior shell. A thermal mass element is disposed in a wiring route between the relay and the connector terminal.

Abstract: When the initiation suppression method was used for translation of a peptide having at its N terminus an amino acid residue carrying a thiol group near its amino group with specific protecting groups being introduced to the thiol group and the amino group, it was found that not only the probability of initiation of amino acid translation reaction was improved, but also production of cleaved peptides was suppressed and translation efficiency and purity were improved. Furthermore, it was found that it is possible to efficiently promote the cyclization reaction of the peptide through amide bond formation. Based on these findings, the inventors discovered novel methods for preparing complexes between nucleic acids and peptides containing various unnatural amino acids and having an amide bond-mediated cyclized portion.

Abstract: Disclosed is a brake control apparatus including a master cylinder that generates a hydraulic braking pressure in response to operation of a brake pedal, an electric motor that drives the master cylinder, a housing in which the master cylinder and the electric motor are assembled, and a control unit adapted to perform drive control of the electric motor. The control unit has a bottom formed at least partially integral with the housing and includes a circuit board mounting thereon drive elements to drive the electric motor. The brake control apparatus includes a heat radiating seat located on an inner surface of the bottom of the control unit at a position apart from the electric motor and closer to the master cylinder than the electric motor and brought into thermal contact with the circuit board so as to radiate heat of the drive elements toward the housing.

Abstract: A brake control apparatus includes a master cylinder configured to generate a brake pressure according to a depressing force of a brake pedal; an electric motor configured to operate the master cylinder; a control board configured to control the electric motor; and a board receiving portion arranged along an outer circumference of the master cylinder. The board receiving portion receives the control board such that a component-mounting surface of the control board faces in an axial direction of the master cylinder.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: To increase vibration resistance of a connection terminal, a tip of which is soldered to a circuit board. In a controller, the circuit board is accommodated in a controller housing made of metal, and the tip of the connection terminal that extends from an actuator housing through an opening is fixed to the circuit board. Semiconductor switching elements and electrolytic capacitors as heat generating components are collectively arranged in an area of the circuit board adjacent to the connection terminal, and the circuit board is adhered and fixed to a top surface of a heat mass via a thermal conductive adhesive. At the same time as that heat dissipation is improved by the thermal conductive adhesive, a load caused by vibration is reduced because the circuit board is fixed at a position near the connection terminal to the controller housing.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: Disclosed is the construction of a system capable of quickly and easily identifying patients having a risk for worsening inflammatory digestive tract disease by identifying a causal factor for the worsening of the inflammatory digestive tract disease. Specifically disclosed is a method for detecting oral bacteria that cause worsening of inflammatory digestive tract disease and/or a screening that targets high risk for worsening of inflammatory digestive tract disease and/or determining the risk for worsening of the inflammatory digestive tract disease by PA not being detected and/or CBP being detected, inclusive of the detection of PA, which is an oral bacteria protein antigen, and/or CBP, which is collagen binding protein, in samples. Also disclosed are a detection reagent and kit used for this method.

Abstract: An electronic control apparatus includes an electric motor including a rotor and a stator; a circuit board configured to drivingly control the electric motor; and a housing unit accommodating the electric motor and the circuit board. A vehicle-body attaching portion of the housing unit is attached and fixed to a vehicle body. The vehicle-body attaching portion is located on one side of the rotor with respect to an extending direction of the rotor. At least one of both surfaces of the circuit board is a component-mounting surface. The circuit board is fixed to the housing unit in a state where the both surface of the circuit board extend along the rotor of the electric motor. A large-size electronic component is mounted on a vehicle-body-attaching-portion-side portion of a peripheral portion of the component-mounting surface which is close to the vehicle-body attaching portion.

Abstract: An electric booster includes a housing having one end including a coupling surface where the housing is coupled to a master cylinder, and the other end including an attachment surface where the housing is attached to a vehicle. A controller includes a flat plate-like control board, and the control board is disposed so as to be positioned between a first plane including the attachment surface of the housing where the housing is attached to the vehicle, and a second plane including the coupling surface of the housing where the housing is coupled to the master cylinder.