Patents by Inventor Kazuhiro Kubo

Kazuhiro Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4962107
    Abstract: Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: October 9, 1990
    Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, Ihara Chemical Kogyo Kabushiki Kaisha
    Inventors: Joji Nakamura, Kazuhiro Kubo, Shunji Ichikawa, Hajime Takahashi, Keisuke Isozumi, Toyofumi Yamada
  • Patent number: 4882351
    Abstract: Novel tricyclic compounds having a TXA.sub.2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A.sub.2 and are expected to have preventive and therapeutic effects on ischemica diseases, cerebro-vascular diseases, etc.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: November 21, 1989
    Assignee: Roussel Uclaf
    Inventors: Etsuo Oshima, Hiroyuki Obase, Akira Karasawa, Kazuhiro Kubo, Ichiro Miki, Akio Ishii
  • Patent number: 4849441
    Abstract: Isoindolin-1-one compounds represented by the following formula (I); ##STR1## {wherein n represents an integer of 1 to 6; m represents 0 or 1; R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen or lower alkyl, and when m is 1, R.sub.1 and one of R.sub.2 and R.sub.3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; ##STR2## [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): ##STR3## (wherein R.sub.6 and R.sub.7 are each independently hydrogen, lower alkyl or lower alkanoyl); R.sub.4 and R.sub.5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a pharmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: July 18, 1989
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kei Okazaki, Etsuo Oshima, Hiroyuki Obase, Yoshimasa Oiji, Masaaki Nito, Kazuhiro Kubo
  • Patent number: 4824842
    Abstract: Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen, methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
    Type: Grant
    Filed: February 13, 1986
    Date of Patent: April 25, 1989
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Joji Nakamura, Kazuhiro Kubo, Shunji Ichikawa, Hajime Takahashi, Keisuke Isozumi, Toyofumi Yamada
  • Patent number: 4677125
    Abstract: Phosphorus-containing oligopeptide derivatives are prepared by synthetic methods. The compounds exhibit angiotensin converting enzyme-inhibiting action and are, therefore, useful as anti-hypertensive agents.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: June 30, 1987
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Mitsuru Takahashi, Hisayo Nomoto, Hiroshi Kase, Katsuichi Shuto, Kazuhiro Kubo, Akira Karasawa
  • Patent number: 4668683
    Abstract: Quinazoline derivatives and their pharmaceutically acceptable acid addition salts having the general formula ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen or alkyl;R.sup.3 represents alkyl or substituted alkyl;R.sup.7 and R.sup.8 each represent alkoxy;Z is oxygen or sulfur;m is zero or 1;n is zero or an integer from 1 to 5,exhibit a cardiotonic activity with little tendency to cause tachycardia.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: May 26, 1987
    Assignee: Kyowa Hakko Kogyo K.K.
    Inventors: Haruki Takai, Yuji Nomoto, Tadashi Hirata, Tetsuji Ohno, Kazuhiro Kubo
  • Patent number: 4450115
    Abstract: New amino-alcohol derivatives and processes for production thereof are disclosed. These compounds exhibit .alpha. and .beta.-adrenergic receptor blocking activity or they act to increase the flow of blood of certain organs.
    Type: Grant
    Filed: July 9, 1981
    Date of Patent: May 22, 1984
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kazuhiro Kubo
  • Patent number: 4446141
    Abstract: The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R.sub.1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.
    Type: Grant
    Filed: February 2, 1980
    Date of Patent: May 1, 1984
    Inventors: Nobuhiro Nakamizo, Hiroyuki Obase, Kazuhiro Kubo, Yutaka Kasuya
  • Patent number: 4410528
    Abstract: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: October 18, 1983
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Hiroyuki Obase, Nobuhiro Nakamizo, Kazuhiro Kubo, Yutaka Kasuya
  • Patent number: 4390536
    Abstract: New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
    Type: Grant
    Filed: February 26, 1982
    Date of Patent: June 28, 1983
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Hiroyuki Obase, Haruki Takai, Kazuhiro Kubo, Yutaka Kasuya
  • Patent number: 4381398
    Abstract: New amino-alcohol derivatives and processes for production thereof are disclosed. These compounds exhibit .alpha. and .beta.-adrenergic receptor blocking activity or they act to increase the flow of blood of certain organs.
    Type: Grant
    Filed: March 18, 1980
    Date of Patent: April 26, 1983
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kazuhiro Kubo
  • Patent number: 4344948
    Abstract: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); m and n are 0 or 1, and are different from each other (i.e., both m and n are not 0 or 1); and (D).sub.m', R.sup.1 and (R.sup.2)n' are usually used as substituents, has a hypotensive activity.
    Type: Grant
    Filed: November 21, 1980
    Date of Patent: August 17, 1982
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Haruki Takai, Masayuki Teranishi, Nobuhiro Nakamizo, Yutaka Kasuya, Kazuhiro Kubo
  • Patent number: 4344945
    Abstract: New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: August 17, 1982
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masayuki Teranishi, Hiroyuki Obase, Haruki Takai, Kazuhiro Kubo, Yutaka Kasuya