Patents by Inventor Kazuhiro Nagaike
Kazuhiro Nagaike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11279911Abstract: A bottle includes a body, a cap mounted to a cap neck of the body. The cap has an outer peripheral portion which is provided with a protrusion. Around the cap, there is provided a position indicator indicating whether the cap is at a correctly closed position, based on the positional relationship between the protrusion and the position indicator.Type: GrantFiled: June 27, 2017Date of Patent: March 22, 2022Assignees: DENSO WAVE INCORPORATED, ANIMAL STEM CELLInventors: Koji Kamiya, Wataru Saito, Kazuhiro Nagaike
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Publication number: 20170369833Abstract: A bottle includes a body, a cap mounted to a cap neck of the body. The cap has an outer peripheral portion which is provided with a protrusion. Around the cap, there is provided a position indicator indicating whether the cap is at a correctly closed position, based on the positional relationship between the protrusion and the position indicator.Type: ApplicationFiled: June 27, 2017Publication date: December 28, 2017Applicants: DENSO WAVE INCORPORATED, ANIMAL STEM CELLInventors: Koji KAMIYA, Wataru SAITO, Kazuhiro NAGAIKE
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Publication number: 20170029756Abstract: The present invention addresses the problem of providing a means, whereby mesenchymal stem cells or adherent cells can be mass-cultured, while monitoring the cell state and strictly maintaining and controlling the same during the course of culture, to obtain cells in an amount as required for treatment of a disease, and can be homogeneously, economically, and efficiently harvested. The present invention also addresses the problem of providing a mass culture container capable of complying with a variety of demands for setting culture conditions; for example, coating of culture surface(s), combination(s) of various types of cells to be adhered to the culture surface(s), and so forth.Type: ApplicationFiled: April 9, 2015Publication date: February 2, 2017Applicant: ANIMAL STEM CELLInventors: Kazuhiro Nagaike, Toshinori Suzuki
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Patent number: 9506892Abstract: A sensor capable of detecting detection targets that are necessary to be detected with high sensitivity is provided. It comprises a field-effect transistor 1A having a substrate 2, a source electrode 4 and a drain electrode 5 provided on said substrate 2, and a channel 6 forming a current path between said source electrode 4 and said drain electrode 5; wherein said field-effect transistor 1A comprises: an interaction-sensing gate 9 for immobilizing thereon a specific substance 10 that is capable of selectively interacting with the detection targets; and a gate 7 applied a voltage thereto so as to detect the interaction by the change of the characteristic of said field-effect transistor 1A.Type: GrantFiled: June 12, 2014Date of Patent: November 29, 2016Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Publication number: 20150102283Abstract: A sensor capable of detecting detection targets that are necessary to be detected with high sensitivity is provided. It comprises a field-effect transistor 1A having a substrate 2, a source electrode 4 and a drain electrode 5 provided on said substrate 2, and a channel 6 forming a current path between said source electrode 4 and said drain electrode 5; wherein said field-effect transistor 1A comprises: an interaction-sensing gate 9 for immobilizing thereon a specific substance 10 that is capable of selectively interacting with the detection targets; and a gate 7 applied a voltage thereto so as to detect the interaction by the change of the characteristic of said field-effect transistor 1A.Type: ApplicationFiled: June 12, 2014Publication date: April 16, 2015Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Patent number: 8772099Abstract: A method of detecting a detection target using a sensor requires a sensor having a transistor selected from the group of field-effect transistors or single electron transistors. The transistor includes a substrate, a source electrode disposed on the substrate and a drain electrode disposed on the substrate, and a channel forming a current path between the source electrode and the drawing electrode; an interaction-sensing gate comprising a specific substance; and a voltage gate. The method includes (a) providing the detection target on the interaction-sensing gate; (b) setting the gate voltage in the voltage gate at a predetermined level; (c) selectively interacting the specific substance with the detection target; (d) when the detection target interacts with the specific substance, changing a gate voltage in the voltage gate to adjust a characteristic of the transistor; and (e) measuring a change in the characteristic of the transistor to determine a presence of the detection target.Type: GrantFiled: July 24, 2012Date of Patent: July 8, 2014Assignee: Japan Science and Technology AgencyInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Patent number: 8766326Abstract: A field-effect transistor or a single electron transistor is used as sensors for detecting a detection target such as a biological compound. A substrate has a first side and a second side, the second side being opposed to the first side. A source electrode is disposed on the first side of the substrate and a drain electrode disposed on the first side of the substrate, and a channel forms a current path between the source electrode and the drain electrode. An interaction-sensing gate is disposed on the second side of the substrate, the interaction-sensing gate having a specific substance that is capable of selectively interacting with the detection target. A gate for applying a gate voltage adjusts a characteristic of the transistor as the detection target changes the characteristic of the transistor when interacting with the specific substance.Type: GrantFiled: July 24, 2012Date of Patent: July 1, 2014Assignee: Japan Science and Technology AgencyInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Patent number: 8502277Abstract: A sensor capable of detecting detection targets that are necessary to be detected with high sensitivity is provided. It comprises a field-effect transistor 1A having a substrate 2, a source electrode 4 and a drain electrode 5 provided on said substrate 2, and a channel 6 forming a current path between said source electrode 4 and said drain electrode 5; wherein said field-effect transistor 1A comprises: an interaction-sensing gate 9 for immobilizing thereon a specific substance 10 that is capable of selectively interacting with the detection targets; and a gate 7 applied a voltage thereto so as to detect the interaction by the change of the characteristic of said field-effect transistor 1A.Type: GrantFiled: August 27, 2004Date of Patent: August 6, 2013Assignee: Japan Science and Technology AgencyInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Publication number: 20120286763Abstract: A method of detecting a detection target using a sensor requires a sensor having a transistor selected from the group of field-effect transistors or single electron transistors. The transistor includes a substrate, a source electrode disposed on the substrate and a drain electrode disposed on the substrate, and a channel forming a current path between the source electrode and the drawing electrode; an interaction-sensing gate comprising a specific substance; and a voltage gate. The method includes (a) providing the detection target on the interaction-sensing gate; (b) setting the gate voltage in the voltage gate at a predetermined level; (c) selectively interacting the specific substance with the detection target; (d) when the detection target interacts with the specific substance, changing a gate voltage in the voltage gate to adjust a characteristic of the transistor; and (e) measuring a change in the characteristic of the transistor to determine a presence of the detection target.Type: ApplicationFiled: July 24, 2012Publication date: November 15, 2012Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Kazuhiko MATSUMOTO, Atsuhiko KOJIMA, Satoru NAGAO, Masanori KATOU, Yutaka YAMADA, Kazuhiro NAGAIKE, Yasuo IFUKU, Hiroshi MITANI
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Publication number: 20120286243Abstract: A field-effect transistor or a single electron transistor is used as sensors for detecting a detection target such as a biological compound. A substrate has a first side and a second side, the second side being opposed to the first side. A source electrode is disposed on the first side of the substrate and a drain electrode disposed on the first side of the substrate, and a channel forms a current path between the source electrode and the drain electrode. An interaction-sensing gate is disposed on the second side of the substrate, the interaction-sensing gate having a specific substance that is capable of selectively interacting with the detection target. A gate for applying a gate voltage adjusts a characteristic of the transistor as the detection target changes the characteristic of the transistor when interacting with the specific substance.Type: ApplicationFiled: July 24, 2012Publication date: November 15, 2012Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Publication number: 20110189233Abstract: A recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing recombinant varicella-zoster virus; a vector containing a genomic gene of varicella-zoster virus and BAC vector sequence; cells containing the above vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; and a nucleic acid cassette containing the BAC vector sequence. For these, there is provided a process for producing recombinant varicella-zoster virus, comprising use of the BAC vector sequence.Type: ApplicationFiled: March 3, 2005Publication date: August 4, 2011Inventors: Kazuhiro Nagaike, Yasuko Mori, Yasuyuki Gomi, Michiaki Takahashi, Kouichi Yamanishi
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Publication number: 20070063304Abstract: A sensor capable of detecting detection targets that are necessary to be detected with high sensitivity is provided. It comprises a field-effect transistor 1A having a substrate 2, a source electrode 4 and a drain electrode 5 provided on said substrate 2, and a channel 6 forming a current path between said source electrode 4 and said drain electrode 5; wherein said field-effect transistor 1A comprises: an interaction-sensing gate 9 for immobilizing thereon a specific substance 10 that is capable of selectively interacting with the detection targets; and a gate 7 applied a voltage thereto so as to detect the interaction by the change of the characteristic of said field-effect transistor 1A.Type: ApplicationFiled: August 27, 2004Publication date: March 22, 2007Inventors: Kazuhiko Matsumoto, Atsuhiko Kojima, Satoru Nagao, Masanori Katou, Yutaka Yamada, Kazuhiro Nagaike, Yasuo Ifuku, Hiroshi Mitani
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Patent number: 7087391Abstract: A hybridoma is selected that produces a monoclonal antibody exhibiting high reactivity to soluble hepatocyte growth factor activator inhibitor-1 (soluble HAI-1), the target monoclonal antibody is prepared from culture supernatant of the obtained hybridoma, and by using the antibody soluble HAI-1 is measured.Type: GrantFiled: May 24, 2002Date of Patent: August 8, 2006Assignee: Mitsubishi Chemical CorporationInventors: Toshiya Yamagishi, Daiji Naka, Kazuhiro Nagaike
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Patent number: 7048944Abstract: A method for preparing a closed vesicle by a rehydration of a closed vesicle using a rehydration solution, wherein said closed vesicle comprises a dehydrated micelle particle or dehydrated amphipathic micelle bilayers, preferably a liposome loading a pharmaceutically active substance, and the method is characterized in that the rehydration is carried out at a low temperature such as in the range of from 0° C. to 10° C. The method can provides a rehydrated stable vesicle without a leak of the loaded substance.Type: GrantFiled: September 25, 2002Date of Patent: May 23, 2006Assignee: Mitsubishi Chemical CorporationInventors: Toshiaki Tagawa, Saiko Hosokawa, Kazuhiro Nagaike
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Publication number: 20050074499Abstract: A ligand-bonded complex which does not react with a free target such as a soluble tumor antigen, but enables substantially specific reaction with a non-free target such as a tumor cell and a tumor antigen existing in the cell.Type: ApplicationFiled: November 29, 2004Publication date: April 7, 2005Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Toshiaki Tagawa, Tsutomu Suzuki, Nobuhisa Yada, Kazuhiro Nagaike, Youko Hirakawa, Saiko Hosokawa
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Patent number: 6787153Abstract: A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surface of a liposome enclosing an anti-cancer agent or toxin is also provided.Type: GrantFiled: December 21, 1999Date of Patent: September 7, 2004Assignee: Mitsubishi Chemical CorporationInventors: Saiko Hosokawa, Toshiaki Tagawa, Yoko Hirakawa, Norihiko Ito, Kazuhiro Nagaike
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Publication number: 20040155309Abstract: A diffraction-grating type sensor chip for analyzing a sample using surface plasmon resonance (SPR), and a method and apparatus for analyzing a sample using the sensor chip. The sensor chip includes a plurality of diffraction grating surfaces (5a-5i) which are disposed in the vicinity of a metal layer (3); the groove pitch and the groove orientation of each diffraction grating surface (5a-5i), in addition to the angle that each diffraction grating surface (5a-5i) forms with a predetermined reference plane (S0), are adjusted in such a manner that when the diffraction grating surfaces (5a-5i) are projected onto a predetermined projection plane, the groove orientations in the projection plane are identical while the groove pitches in the projection plane are different among the diffraction grating surfaces (5a-5i).Type: ApplicationFiled: February 6, 2004Publication date: August 12, 2004Inventors: Takaaki Sorin, Hidehito Takayama, Kazuhiro Nagaike
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Publication number: 20030064420Abstract: A hybridoma is selected that produces a monoclonal antibody exhibiting high reactivity to soluble hepatocyte growth factor activator inhibitor-1 (soluble HAT-1), the target monoclonal antibody is prepared from culture supernatant of the obtained hybridoma, and by using the antibody soluble HAI-1 is measured.Type: ApplicationFiled: May 24, 2002Publication date: April 3, 2003Inventors: Toshiya Yamagishi, Daiji Naka, Kazuhiro Nagaike
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Publication number: 20030022379Abstract: A method for preparing a closed vesicle by a rehydration of a closed vesicle using a rehydration solution, wherein said closed vesicle comprises a dehydrated micelle particle or dehydrated amphipathic micelle bilayers, preferably a liposome loading a pharmaceutically active substance, and the method is characterized in that the rehydration is carried out at a low temperature such as in the range of from 0° C. to 10° C. The method can provides a rehydrated stable vesicle without a leak of the loaded substance.Type: ApplicationFiled: September 25, 2002Publication date: January 30, 2003Inventors: Toshiaki Tagawa, Saiko Hosokawa, Kazuhiro Nagaike
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Patent number: 6475517Abstract: A method for preparing a closed vesicle by a rehydration of a closed vesicle using a rehydration solution, wherein the closed vesicle comprises a dehydrated micelle particle or dehydrated amphipathic micelle bilayers, preferably a liposome loading a pharmaceutically active substance, and the method is characterized in that the rehydration is carried out at a low temperature such as in the range of from 0° C. to 10° C. The method can provide a rehydrated stable vesicle without a leak of the loaded substance.Type: GrantFiled: July 5, 2001Date of Patent: November 5, 2002Assignee: Mitsubishi Chemical CorporationInventors: Toshiaki Tagawa, Saiko Hosokawa, Kazuhiro Nagaike