Patents by Inventor Kazuki Hemmi

Kazuki Hemmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolopyrimidine derivative
    Patent number: 8815874
    Abstract: The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(?O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: August 26, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Kazuki Hemmi
  • CHEMOKINE RECEPTOR ACTIVITY REGULATOR
    Publication number: 20140221340
    Abstract: The invention provides a chemokine receptor activity modulator containing a pyrazolopyrimidine derivative represented by the formula (I) wherein R1, R2, R3, and R4 are as described herein.
    Type: Application
    Filed: August 31, 2012
    Publication date: August 7, 2014
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Kazuki Hemmi, Mirai Mizutani, Yuko Seno
  • Agent for prevention and/or treatment of skin diseases
    Patent number: 8729264
    Abstract: Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 20, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Daisuke Nakashima, Kimihisa Ueno, Mirai Mizutani, Daisuke Harada, Katsuya Kobayashi, Kazuki Hemmi
  • PYRAZOLOPYRIMIDINE DERIVATIVE
    Publication number: 20130102620
    Abstract: The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(?O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
    Type: Application
    Filed: March 4, 2011
    Publication date: April 25, 2013
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Kazuki Hemmi
  • Tricyclic compounds
    Patent number: 8242151
    Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: August 14, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo
  • AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES
    Publication number: 20100256134
    Abstract: Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
    Type: Application
    Filed: September 26, 2008
    Publication date: October 7, 2010
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Keisuke Yamamoto, Seiji Aratake, Daisuke Nakashima, Kimihisa Ueno, Mirai Mizutani, Daisuke Harada, Katsuya Kobayashi, Kazuki Hemmi
  • TRICYCLIC COMPOUNDS
    Publication number: 20090176760
    Abstract: The present invention provides a PPAR ? agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH?CH—CH?CH or the like, Y represents a single bond or the like, Z1-Z2 represents C?CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
    Type: Application
    Filed: February 7, 2008
    Publication date: July 9, 2009
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Arata Yanagisawa, Takeshi Kuboyama, Seiji Aratake, Kazuki Hemmi, Kimihisa Ueno, Michihiko Suzuki, Masahiro Matsubara, Kozo Yao, Akinori Hamaguchi, Yukihito Tsukumo