Abstract: A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein R1 is a hydrogen atom or an acyl group and R2 and R3 are, the same or different, a hydrogen atom or a hydroxyl group, or a salt thereof and the stabilizer.

Abstract: The present invention provides a pipecolic acid derivative-containing liposome preparation having has an excellent rapid action capable of coping with an emergent situation such as cerebral infarction. A liposome preparation characterized by comprising, as an active ingredient, a pipecolic acid derivative of the ingredient described in the present specification or a pharmaceutically acceptable salt thereof entrapped into liposomes, wherein lecithin is mainly used as the liposome-forming lipid, said liposome preparation containing no cholesterol as a stabilizer.

Abstract: An object of the present invention is to provide a method for producing a liposome preparation having excellent rapid action and excellent redispersion into aqueous medium. The present invention provides a method for producing a liposome preparation by vacuum drying wherein liposome condensed solution, which is obtained by removing solvent from liposome solution, is subjected to vacuum drying without freezing while bubbling the condensed solution or after the condensed solution is bubbled.

Abstract: A stabilized pharmaceutical composition in lyophilized form comprising:

Abstract: The present invention provides a pipecolic acid derivative-containing liposome preparation having has an excellent rapid action capable of coping with an emergent situation such as cerebral infarction.

Abstract: Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to −20° C. for a time sufficient to grow ice crystals, to form a primarily frozen substance, then subjecting said primarily frozen substance to a secondary freezing at from −25° C. to −80° C. to form a completely frozen solid, and then drying the resulting frozen solid in vacuo; and product obtained by the process.

Abstract: A drug delivery device includes a cylinder having a large diameter and a drug delivery member coaxially fitted to one end of the cylinder and in fluid communication therewith, the drug delivery member having a diameter substantially smaller than that of the cylinder. Drug delivery orifices are formed only at a side wall of the drug delivery member at an end thereof opposite the cylinder. A plunger fittable into an end of the cylinder opposite the drug delivery member has a disc portion and a central projection which fits into the drug delivery member. A cap covering the drug delivery member has an annular projection on the inside thereof for sealing the drug delivery member.