Patents by Inventor Kazunari Fukumoto

Kazunari Fukumoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11407787
    Abstract: The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: August 9, 2022
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro Fujimoto, Kazunari Fukumoto, Hiroshi Nagano
  • Patent number: 11192851
    Abstract: An object of the present invention is to provide a crystal of L-alanyl-L-glutamine having a low loose specific volume, and a method for producing the same. The present invention relates to a crystal of L-alanyl-L-glutamine in which the loose specific volume is 5.0 mL/g or less, and a method for producing the same.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 7, 2021
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari Fukumoto
  • Patent number: 11186605
    Abstract: An object of the present invention is to provide a crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties, and a production method thereof. According to the present invention, the crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties can be obtained by precipitating the crystal of cytidine diphosphate choline in an aqueous solution in which cytidine diphosphate choline is dissolved, collecting the precipitated crystal of cytidine diphosphate choline, and washing the collected crystal of cytidine diphosphate choline with an aqueous solution containing an organic solvent other than methanol in which a water content is 5% to 50% by volume.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: November 30, 2021
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari Fukumoto
  • Patent number: 10858393
    Abstract: According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 8, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari Fukumoto, Maya Iguchi, Hiroshi Nagano
  • Publication number: 20200369721
    Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari FUKUMOTO, Maya IGUCHI, Hiroshi NAGANO
  • Patent number: 10774109
    Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 15, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari Fukumoto, Maya Iguchi, Hiroshi Nagano
  • Patent number: 10745432
    Abstract: An object of the present invention is to provide a crystal of 6?-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a production process thereof. The present invention relates to a crystal of 6SL sodium salt and a process for producing the crystal.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 18, 2020
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Masahiro Abe, Tomoya Yokoi, Sotaro Sanpei, Kazunari Fukumoto, Hiroshi Nagano
  • Patent number: 10640532
    Abstract: The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 5, 2020
    Assignees: University Public Corporation Osaka, Kyowa Hakko Bio Co., Ltd.
    Inventors: Hiroshi Ooshima, Koichi Igarashi, Hiroshi Nagano, Akihiro Fujimoto, Kenta Fukumoto, Kazunari Fukumoto, Tomoya Yokoi
  • Publication number: 20200095279
    Abstract: The present application discloses a crystal of oxidized glutathione dication salt and a method of producing the same.
    Type: Application
    Filed: June 6, 2018
    Publication date: March 26, 2020
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Akihiro FUJIMOTO, Kazunari FUKUMOTO, Hiroshi NAGANO
  • Publication number: 20190382337
    Abstract: An object of the present invention is to provide a crystal of L-alanyl-L-glutamine having a low loose specific volume, and a method for producing the same. The present invention relates to a crystal of L-alanyl-L-glutamine in which the loose specific volume is 5.0 mL/g or less, and a method for producing the same.
    Type: Application
    Filed: December 20, 2017
    Publication date: December 19, 2019
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari FUKUMOTO
  • Patent number: 10407463
    Abstract: The invention provides a method of efficiently and stably producing ?-form crystal of reduced glutathione, and a preservation method thereof. According to the invention, development of ?-form crystal and/or transition to ?-form crystal of reduced glutathione are suppressed by the coexistence of at least one kind of compound selected from the group of aliphatic amino acid, sulfur-containing amino acid, aromatic amino acid, an analogous compound and dipeptide, as a habit modifier, during production and preservation of an aqueous solution or ?-form crystal of reduced glutathione.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 10, 2019
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Maya Iguchi, Kazunari Fukumoto, Hiroshi Nagano
  • Publication number: 20190225642
    Abstract: An object of the present invention is to provide a crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties, and a production method thereof. According to the present invention, the crystal of cytidine diphosphate choline which contains no methanol and has improved powder properties can be obtained by precipitating the crystal of cytidine diphosphate choline in an aqueous solution in which cytidine diphosphate choline is dissolved, collecting the precipitated crystal of cytidine diphosphate choline, and washing the collected crystal of cytidine diphosphate choline with an aqueous solution containing an organic solvent other than methanol in which a water content is 5% to 50% by volume.
    Type: Application
    Filed: October 6, 2017
    Publication date: July 25, 2019
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari FUKUMOTO
  • Publication number: 20190085023
    Abstract: The present invention provides a crystal of reduced glutathione having excellent powder properties and a method for producing the same. The present invention relates to a crystal of reduced glutathione, wherein the average crystal thickness is 10 ?m or more.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 21, 2019
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari FUKUMOTO, Maya IGUCHI, Hiroshi NAGANO
  • Publication number: 20190071466
    Abstract: According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari FUKUMOTO, Maya IGUCHI, Hiroshi NAGANO
  • Publication number: 20180305388
    Abstract: An object of the present invention is to provide a crystal of 6?-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a production process thereof. The present invention relates to a crystal of 6SL sodium salt and a process for producing the crystal.
    Type: Application
    Filed: November 18, 2016
    Publication date: October 25, 2018
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Masahiro ABE, Tomoya YOKOI, Sotaro SANPEI, Kazunari FUKUMOTO, Hiroshi NAGANO
  • Patent number: 10072038
    Abstract: According to the present invention, a crystal of ammonium N-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an ammonium-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of ammonium N-acetylneuraminate anhydrate, and collecting the crystal of ammonium N-acetylneuraminate anhydrate from the aqueous solution, can be provided.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: September 11, 2018
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari Fukumoto
  • Patent number: 10005808
    Abstract: According to the present invention, a crystal of an alkali metal N-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an alkali metal-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of an alkali metal N-acetylneuraminate anhydrate, and collecting the crystal of an alkali metal N-acetylneuraminate anhydrate from the aqueous solution, can be provided.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: June 26, 2018
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Kazunari Fukumoto, Masahiro Abe
  • Publication number: 20180170959
    Abstract: The invention provides a method of efficiently and stably producing ?-form crystal of reduced glutathione, and a preservation method thereof. According to the invention, development of ?-form crystal and/or transition to ?-form crystal of reduced glutathione are suppressed by the coexistence of at least one kind of compound selected from the group of aliphatic amino acid, sulfur-containing amino acid, aromatic amino acid, an analogous compound and dipeptide, as a habit modifier, during production and preservation of an aqueous solution or ?-form crystal of reduced glutathione.
    Type: Application
    Filed: June 3, 2016
    Publication date: June 21, 2018
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventors: Maya IGUCHI, Kazunari FUKUMOTO, Hiroshi NAGANO
  • Publication number: 20180094025
    Abstract: The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.
    Type: Application
    Filed: March 31, 2016
    Publication date: April 5, 2018
    Applicants: Osaka City University, Kyowa Hakko Bio Co., Ltd.
    Inventors: Hiroshi OOSHIMA, Koichi IGARASHI, Hiroshi NAGANO, Akihiro FUJIMOTO, Kenta FUKUMOTO (deceased), Kazunari FUKUMOTO, Tomoya YOKOI
  • Publication number: 20180002364
    Abstract: According to the present invention, a crystal of ammonium N-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium N-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous N-acetylneuraminic acid solution containing an ammonium-containing compound and having a pH of 3.0 to 9.0 to precipitate a crystal of ammonium N-acetylneuraminate anhydrate, and collecting the crystal of ammonium N-acetylneuraminate anhydrate from the aqueous solution, can be provided.
    Type: Application
    Filed: January 27, 2016
    Publication date: January 4, 2018
    Applicant: KYOWA HAKKO BIO CO., LTD.
    Inventor: Kazunari FUKUMOTO