Patents by Inventor Kazuo Saitoh

Kazuo Saitoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8945469
    Abstract: A magnetic immunoassay system with a mechanism for compensating the direct current residual magnetic field in the vicinity of the specimen measurement position, in a direction perpendicular to the magnetic marker direction of magnetization for the measurement target. This invention reduces the effects of the magnetic field emitted from the unbound magnetic marker due to the residual magnetic field in the specimen solution and detects with high sensitivity the signal of the bound target magnetic marker. The magnetic field at the measurement position is regulated so as to intersect the direction of magnetization of the magnetic marker for the measurement target, in order to make the magnetization direction of the magnetic marker that is unbound due to residual magnetism or remanence in the sample solution, intersect the magnetization direction of the magnetic marker for the measurement target.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: February 3, 2015
    Assignee: Hitachi, Ltd.
    Inventors: Akira Tsukamoto, Kazuo Saitoh
  • Patent number: 7993581
    Abstract: The present invention provides an immunoassay technique which enables efficient detection of antigen-antibody reaction with high sensitivity by a magnetic method using magnetic particles and a SQUID magnetic sensor or sensors. A system based on the technique includes a disk-shaped sample holder which holds on a circle a plurality of sample containers for accommodating marked samples, resulting from marking of samples with magnetic particles by antigen-antibody reaction; rotating means for rotating the holder around its central shaft; magnetizing means for magnetizing the marked samples outside a magnetic shield; and a magnetic sensor for detecting, within the magnetic shield, magnetic fields generated from the marked samples which have been magnetized.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: August 9, 2011
    Assignee: Hitachi, Ltd.
    Inventors: Yusuke Seki, Akira Tsukamoto, Daisuke Suzuki, Masahiro Yamaoka, Nami Sugita, Akihiko Kandori, Kazuo Saitoh
  • Patent number: 7898256
    Abstract: An NMR measurement apparatus adopts a circulation flow scheme using a sample solution containing a high molecular compound representing a measuring object and a low molecular compound solution containing a low molecular compound representing a ligand. The measurement apparatus comprises a mixing filter 32 for mixing the sample solution and the low molecular compound solution, a separation filter 34 for performing separation therebetween, a flow channel 1 through which the sample solution drained out of the separation filter 34 is injected to the mixing filter 32, a flow channel 2 through which the low molecular compound solution drained out of the separation filter 34 is injected to the mixing filter 32, and a flow channel 3 through which the mixture solution drained out of the mixing filter 32 is injected to the separation filter 34 by way of a reservoir 10.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: March 1, 2011
    Assignee: Hitachi, Ltd.
    Inventors: Isao Kitagawa, Michiya Okada, Kazuo Saitoh
  • Patent number: 7808242
    Abstract: A probe for nuclear magnetic resonance (NMR) measurement provided with a multiple resonant circuit for detecting signals of two or more nuclides with high detection efficiency for nuclide at low resonant frequency comprises a multiple resonance radio frequency (RF) coil circuit that, with multiple lead lines connected to the RF coil, causes a part of the RF coil, separated by the connection points of the lead lines, to function as the inductor of a trap circuit that cuts off a signal at the frequency F1 for a signal at the resonant frequency F1 of a first nuclide and, at the same time, to function as an RF coil that detects a signal at the frequency F2 for a signal at the resonant frequency F2 of a second nuclide, thus increasing the signal detection efficiency for the nuclide at the frequency F2.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: October 5, 2010
    Assignee: Hitachi, Ltd.
    Inventors: Hiroyuki Yamamoto, Kazuo Saitoh, Kenji Kawasaki, Yuzo Fukuda, Michiya Okada
  • Patent number: 7639014
    Abstract: It is an object of the invention to provide, in a nuclear magnetic resonance spectrometer wherein the direction of the static magnetic field is the horizontal direction, a nuclear magnetic resonance probe coil having a highly uniform magnetic field, which can measure at high sensitivity. The present invention, by selecting the design and shapes of the materials forming the probe coil with a view to suppressing disorder in the magnetic field distribution, and using superconducting thin film coils formed on hollow circular substrates to form a receiver coil and coil support materials having curved surfaces, provides a nuclear magnetic resonance spectrometer of high sensitivity that can improve uniformity of a magnetic field.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: December 29, 2009
    Assignee: Hitachi, Ltd.
    Inventors: Haruhiro Hasegawa, Hiroyuki Yamamoto, Kazuo Saitoh
  • Patent number: 7619414
    Abstract: A signal line is drawn from a generally middle point of the antenna coil, and a capacitance-variable capacitors are connected at both sides of the antenna coil. This structure realizes a circuit in which a series resonance circuit composed of an antenna coil and a capacitor and an another series resonance circuit composed of an another antenna coil and an another capacitor are connected in parallel to each other across the generally middle point of the antenna coil to which the signal line is connected. Through the control of the resonance frequencies of the series resonance circuits, the parallel resonance frequency of the whole antenna is tuned to a desired frequency, and the resonance characteristic in which the impedance is matched to a specific value, e.g., 50 ?, can be achieved.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: November 17, 2009
    Assignee: Hitachi, Ltd.
    Inventors: Hiroyuki Yamamoto, Takanori Ninomiya, Kazuo Saitoh
  • Patent number: 7609064
    Abstract: A probe for a nuclear magnetic resonance apparatus comprises: a transmission coil for irradiating a sample with a high-frequency electromagnetic wave; and a receiving coil for detecting a nuclear magnetic resonance signal emitted by the sample, wherein a selector switch is disposed to the transmission coil to reduce the deterioration of sensitivity of the receiving coil by switching the resonance state of the transmission circuit between during irradiation and during detection, even if an electromagnetic coupling remains between transmission and reception.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 27, 2009
    Assignee: Hitachi, Ltd.
    Inventors: Yuzo Fukuda, Kazuo Saitoh, Hiroyuki Yamamoto, Michiya Okada
  • Publication number: 20090212776
    Abstract: An NMR measurement apparatus adopts a circulation flow scheme using a sample solution containing a high molecular compound representing a measuring object and a low molecular compound solution containing a low molecular compound representing a ligand. The measurement apparatus comprises a mixing filter 32 for mixing the sample solution and the low molecular compound solution, a separation filter 34 for performing separation therebetween, a flow channel 1 through which the sample solution drained out of the separation filter 34 is injected to the mixing filter 32, a flow channel 2 through which the low molecular compound solution drained out of the separation filter 34 is injected to the mixing filter 32, and a flow channel 3 through which the mixture solution drained out of the mixing filter 32 is injected to the separation filter 34 by way of a reservoir 10.
    Type: Application
    Filed: February 17, 2009
    Publication date: August 27, 2009
    Inventors: Isao Kitagawa, Michiya Okada, Kazuo Saitoh
  • Publication number: 20090165262
    Abstract: The present invention relates to a long article, such as belts or junction means of buckle members for wearing, such as bag articles including magazine pouches that are used by those who handle machine guns in terrorism incidents and fights, magazine belts or vests that become members for attaching the magazine pouches, or junction means of buckle members for attaching magazine pouches and the like. The object of the present invention is to provide various kinds of buckles which are made of engineering polymers, titanium and stainless steel plates and the like in order to meet requirements for the modernization of equipment, which are novel and strong and permit easy attachment, which are lightweight and easy to carry, and in which male and female members do not disengage from each other, and a junction device that can release the junction of the buckles in an emergency and as required.
    Type: Application
    Filed: December 28, 2007
    Publication date: July 2, 2009
    Inventors: Masahiro Shimamura, Kazuo Saitoh
  • Publication number: 20090121718
    Abstract: A probe for nuclear magnetic resonance (NMR) measurement provided with a multiple resonant circuit for detecting signals of two or more nuclides with high detection efficiency for nuclide at low resonant frequency comprises a multiple resonance radio frequency (RF) coil circuit that, with multiple lead lines connected to the RF coil, causes a part of the RF coil, separated by the connection points of the lead lines, to function as the inductor of a trap circuit that cuts off a signal at the frequency F1 for a signal at the resonant frequency F1 of a first nuclide and, at the same time, to function as an RF coil that detects a signal at the frequency F2 for a signal at the resonant frequency F2 of a second nuclide, thus increasing the signal detection efficiency for the nuclide at the frequency F2.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 14, 2009
    Inventors: Hiroyuki YAMAMOTO, Kazuo Saitoh, Kenji Kawasaki, Yuzo Fukuda, Michiya Okada
  • Patent number: 7501877
    Abstract: Objects of the present invention are to provide an integration circuit which produces no integration leak so that the bit accuracy is improved in a sigma-delta modulation circuit or a delta modulator circuit, which is based on a single flux quantum circuit that uses a flux quantum as an information carrier, and to provide a method for reducing thermal noise and quantization noise. According to the present invention, an integration circuit is formed by Josephson junctions and an inductor to reduce the integration leak, and a plurality of modulator circuits are connected to one another so as to add up each output. As a result, it is possible to reduce the influence of thermal noise exerted upon the bit accuracy, the thermal noise having no correlativity to one another.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: March 10, 2009
    Assignee: Hitachi, Ltd.
    Inventors: Futoshi Furuta, Kazuo Saitoh
  • Patent number: 7471087
    Abstract: A NMR probe which causes only a minimum disturbance to magnetic-field uniformity, and which acquires a high resonant Q value. A detection coil 1 for detecting a nuclear magnetic resonance signal emitted from a sample 3 measured, and a compensation coil 4 composed of a superconducting material for compensating for inductance of the detection coil 1 are electrically connected in series with each other. Moreover, a tuning-dedicated variable capacitor 6 is connected to the detection coil 1 in series therewith, and a matching-dedicated variable capacitor 5 is connected to the compensation coil 4 in series therewith. Furthermore, a coaxial cable 9 is connected to both ends of the matching-dedicated variable capacitor 5. This configuration allows detection of the signal.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: December 30, 2008
    Assignee: Hitachi, Ltd.
    Inventors: Yuzo Fukuda, Kazuo Saitoh
  • Publication number: 20080290872
    Abstract: A sample tube is used to ensure uniformity in a static magnetic field and uniformity in electromagnetic wave irradiation for NMR measurement for continuous sample injection. The sample tube is formed of a signal detecting tube having a length lying between 80% and 100% of the length of an antenna, the signal detecting tube accommodating a sample at the position of the antenna; first and second joint tubes each having an outside diameter equal to the outside diameter of the signal detecting tube and having an inside diameter smaller than the inside diameter of the signal detecting tube; and injection and ejection supporting tubes each having an inside diameter smaller than the inside diameter of the signal detecting tube. The first and second joint tubes have magnetic susceptibility matched to or brought close to that of a sample solvent.
    Type: Application
    Filed: May 16, 2008
    Publication date: November 27, 2008
    Inventors: Isao Kitagawa, Michiya Okada, Kazuo Saitoh
  • Publication number: 20080262757
    Abstract: In a leakage detection system configured by arranging a number of gas sensors, a leakage spot is promptly and accurately estimated. An output voltage of the each sensor is converted into concentration, and a time differential coefficient of the concentration is obtained. A leakage spot is estimated to be on a straight line connecting between the sensors for which the time differential coefficient is large.
    Type: Application
    Filed: April 15, 2008
    Publication date: October 23, 2008
    Inventors: Koichi Yokosawa, Sadaki Nakano, Kazuo Saitoh
  • Publication number: 20080252294
    Abstract: It is an object of the invention to provide, in a nuclear magnetic resonance spectrometer wherein the direction of the static magnetic field is the horizontal direction, a nuclear magnetic resonance probe coil having a highly uniform magnetic field, which can measure at high sensitivity. The present invention, by selecting the design and shapes of the materials forming the probe coil with a view to suppressing disorder in the magnetic field distribution, and using superconducting thin film coils formed on hollow circular substrates to form a receiver coil and coil support materials having curved surfaces, provides a nuclear magnetic resonance spectrometer of high sensitivity that can improve uniformity of a magnetic field.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 16, 2008
    Inventors: Haruhiro Hasegawa, Hiroyuki Yamamoto, Kazuo Saitoh
  • Publication number: 20080231277
    Abstract: The present invention provides a highly-sensitive nuclear magnetic resonance (NMR) spectrometer which achieves a high Q factor using a superconductor, and concurrently which is provided with a probe antenna maintaining the magnetic homogeneity of the static magnetic field in a sample space. An antenna coil is fabricated by using a wire having a superconducting layer formed on the surface of a metal wire.
    Type: Application
    Filed: January 23, 2008
    Publication date: September 25, 2008
    Inventors: Hiroyuki Yamamoto, Kazuo Saitoh, Haruhiro Hasegawa, Masaya Takahashi, Michiya Okada
  • Publication number: 20080129368
    Abstract: Objects of the present invention are to provide an integration circuit which produces no integration leak so that the bit accuracy is improved in a sigma-delta modulation circuit or a delta modulator circuit, which is based on a single flux quantum circuit that uses a flux quantum as an information carrier, and to provide a method for reducing thermal noise and quantization noise. According to the present invention, an integration circuit is formed by Josephson junctions and an inductor to reduce the integration leak, and a plurality of modulator circuits are connected to one another so as to add up each output. As a result, it is possible to reduce the influence of thermal noise exerted upon the bit accuracy, the thermal noise having no correlativity to one another.
    Type: Application
    Filed: June 8, 2007
    Publication date: June 5, 2008
    Inventors: Futoshi Furuta, Kazuo Saitoh
  • Publication number: 20080111548
    Abstract: A signal line is drawn from a generally middle point of the antenna coil, and a capacitance-variable capacitors are connected at both sides of the antenna coil. This structure realizes a circuit in which a series resonance circuit composed of an antenna coil and a capacitor and an another series resonance circuit composed of an another antenna coil and an another capacitor are connected in parallel to each other across the generally middle point of the antenna coil to which the signal line is connected. Through the control of the resonance frequencies of the series resonance circuits, the parallel resonance frequency of the whole antenna is tuned to a desired frequency, and the resonance characteristic in which the impedance is matched to a specific value, e.g., 50 ?, can be achieved.
    Type: Application
    Filed: November 8, 2007
    Publication date: May 15, 2008
    Inventors: Hiroyuki Yamamoto, Takanori Ninomiya, Kazuo Saitoh
  • Patent number: 7358736
    Abstract: The invention provides a low temperature probe having a high sensitivity by reducing a heat intrusion into a receive coil. A heat making an intrusion into a coil is suppressed by inserting a heat radiation shield in which a temperature is controlled at about 100 K to a portion between an outer container of a probe and a coil portion. A heat radiation shield bore sleeve is provided in a heat radiation bore, is connected to the heat radiation shield, and is cooled by a second heat exchanger. Further, the coil portion is cooled by a first heat exchanger. In preparation for a contraction at a time of being cooled, the outer container, the heat radiation shield and the coil portion are connected by using a fixing portion, and a heat relieving mechanism or a contraction relieving mechanism is provided in a root side (an opposite side to the fixing portion) of the heat radiation shield and the coil portion.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: April 15, 2008
    Assignee: Hitachi, Ltd.
    Inventors: Yuzo Fukuda, Hiromitsu Seino, Kazuo Saitoh, Hiroyuki Tanaka, Tsuyoshi Wakuda, Norihide Saho, Michiya Okada
  • Patent number: 7352186
    Abstract: Provided is a nuclear magnetic resonance probe coil that is included in a nuclear magnetic resonance apparatus in which the direction of a static magnetic field is horizontal and that can highly sensitively measure multiple nuclear species. A nuclear magnetic resonance apparatus includes a unit that horizontally applies a static magnetic field, a unit that vertically moves a specimen to a predetermined position in the apparatus, and a probe including in the distal part thereof a probe coil that applies a radiofrequency signal to the specimen and that detects a signal produced by the specimen.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: April 1, 2008
    Assignee: Hitachi, Ltd.
    Inventors: Haruhiro Hasegawa, Hiroyuki Yamamoto, Kazuo Saitoh