Abstract: A method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is [1-13C] N-acetyl cysteine, a deuterated derivative thereof, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient; and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing [1-13C] N-acetyl cysteine or a deuterated derivative thereof.

Abstract: Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.

Abstract: Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.

Abstract: This silver-coated spherical resin includes: a spherical resin; and silver coated on a surface of the spherical resin, wherein an amount of the silver is in a range of 2 to 80 parts by mass with respect to 100 parts by mass of the silver-coated spherical resin, and a crystallite diameter of the silver measured by X-ray diffractometry is in a range of 18 to 24 nm. This method for producing a silver-coated spherical resin includes: a process of subjecting a spherical resin to a pretreatment using an aqueous solution of a tin compound; and a subsequent process of subjecting the spherical resin to an electroless silver plating using a reducing agent, wherein, during the pretreatment, a temperature of the aqueous solution of the tin compound is set to be in a range of 20 to 45° C.

Abstract: This silver-coated spherical resin includes: a spherical resin; and silver coated on a surface of the spherical resin, wherein an amount of the silver is in a range of 2 to 80 parts by mass with respect to 100 parts by mass of the silver-coated spherical resin, and a crystallite diameter of the silver measured by X-ray diffractometry is in a range of 18 to 24 nm. This method for producing a silver-coated spherical resin includes: a process of subjecting a spherical resin to a pretreatment using an aqueous solution of a tin compound; and a subsequent process of subjecting the spherical resin to an electroless silver plating using a reducing agent, wherein, during the pretreatment, a temperature of the aqueous solution of the tin compound is set to be in a range of 20 to 45° C.

Abstract: Provided is an axial fan apparatus including a housing and an axial-flow impeller. The axial-flow impeller is capable of rotating inside the housing and includes a plurality of axial-flow wings each having a negative pressure generation surface for generating a negative pressure, and an auxiliary vane standing on the negative pressure generation surface at an end portion of each of the plurality of axial-flow wings.

Abstract: A composite optical element is provided. The composite optical element includes a plurality of optical elements, in which at least one of the optical elements is formed of an element modifying an optical path and the other optical elements are bonded to an incident surface and/or exit surface of the element modifying the optical path with a low refractive index material layer in between.

Abstract: An evaporator unit includes an evaporator configured to evaporate a refrigerant, and a capillary tube configured to decompress the refrigerant. The capillary tube has two longitudinal ends bonded to the evaporator. At least one position of a middle portion between the two longitudinal ends of the capillary tube is fixed to the evaporator by press-contacting the evaporator. Therefore, it can prevent a crack from being caused at the bonding portions of the two longitudinal ends of the capillary tube.

Abstract: Prior to assembly of an elastic member (51) to a slinger (52), a radially inner surface (58) of a first portion (56) is formed in a concave shape, and a radially inner surface (59) of a second portion (57) is formed in a conical shape. The second axial lip (55) is adapted such that, after the elastic member (51) is assembled to the slinger (52) and when a second axial lip (55) is in a not-yet-worn state, the second axial lip (55) does not come into contact with a fixation section (65) of the slinger (52).

Abstract: An axial fan apparatus including an axial-flow impeller, a drive unit, and a housing. The axial-flow impeller is capable of rotating and includes a plurality of blades inclined with respect to a rotational axis direction. The drive unit rotates the axial-flow impeller. The housing is mounted with the drive unit, and includes a sidewall, and a plurality of slits that circulate gas. The sidewall is provided around the axial-flow impeller. The plurality of slits are provided to the sidewall and inclined with respect to the rotational axis direction in a direction opposed to a direction in which the plurality of blades incline.

Abstract: There is provided an axial fan apparatus including an axial-flow impeller, a drive unit, and a housing. The axial-flow impeller is capable of rotating and includes a plurality of blades inclined with respect to a rotational axis direction. The drive unit rotates the axial-flow impeller. The housing is mounted with the drive unit, and includes a sidewall, and a plurality of slits that circulate gas. The sidewall is provided around the axial-flow impeller. The plurality of slits are provided to the sidewall and inclined with respect to the rotational axis direction in a direction opposed to a direction in which the plurality of blades incline.

Abstract: A sealing apparatus includes a slinger which includes a cylindrical portion, and radially-extending portions and provided respectively at axially-opposite ends of the cylindrical portion and an elastic member which includes a base portion fixed to a surface of an inner radially-extending portion of a radially-extending core metal member, and a lip portion connected with the base portion. The lip portion is formed by a first axial lip contacting one radially-extending portion of the slinger and a second axial lip contacting the other radially-extending portion of the slinger. The elastic member is formed such that in an axial cross-section, the distance between a cylindrical portion-opposing surface of the elastic member radially opposed to the cylindrical portion and the cylindrical portion is increasing generally uniformly axially outward.

Abstract: The invention provides a sealing device in which adhesion of an elastic member used for the sealing device is controlled, and a coefficient of friction against a member sliding against the sealing device is reduced. A sealing device includes a first member 1, a second member 2 moving relative to the first member, and an elastic member 3 fixed to the first member 1 and sliding against the second member 2, and is characterized in that: the elastic member 3 is made of a rubber composition containing a metal soap, an organic acid amide and an oil-containing particle.

Abstract: The invention provides a sealing device, a rolling bearing and a rolling bearing for a wheel, in which a torque can be reduced, and also the air and lubricant are less liable to escape from the interior of the bearing to the exterior of the bearing, and the air and foreign matters are less liable to intrude into the bearing from the exterior of the bearing.

Abstract: The invention provides a sealing device, a rolling bearing and a rolling bearing for a wheel, in which a torque can be reduced, and also the air and lubricant are less liable to escape from the interior of the bearing to the exterior of the bearing, and the air and foreign matters are less liable to intrude into the bearing from the exterior of the bearing. A bottom 73 of an axial concave portion in a surface of an elastic member 51 forming a radial lip 70, facing away from a flange portion in an axial direction overlaps an end face 77 of a radially-extending portion 61 of a core metal member 50, facing a tubular portion 65, in a radial direction. A bottom 81 of a radial concave portion of the elastic member 51 forming the radial lip 70, facing the tubular portion 65 of a slinger 52 is spaced from the end face 77 of the core metal member 50 toward a flange portion 66 in the axial direction.

Abstract: Prior to assembly of an elastic member (51) to a slinger (52), a radially inner surface (58) of a first portion (56) is formed in a concave shape, and a radially inner surface (59) of a second portion (57) is formed in a conical shape. The second axial lip (55) is adapted such that, after the elastic member (51) is assembled to the slinger (52) and when a second axial lip (55) is in a not-yet-worn state, the second axial lip (55) does not come into contact with a fixation section (65) of the slinger (52).

Abstract: A composite optical element is provided. The composite optical element includes a plurality of optical elements, in which at least one of the optical elements is formed of an element modifying an optical path and the other optical elements are bonded to an incident surface and/or exit surface of the element modifying the optical path with a low refractive index material layer in between.

Abstract: An evaporator unit includes an evaporator configured to evaporate a refrigerant, and a capillary tube configured to decompress the refrigerant. The capillary tube has two longitudinal ends bonded to the evaporator. At least one position of a middle portion between the two longitudinal ends of the capillary tube is fixed to the evaporator by press-contacting the evaporator. Therefore, it can prevent a crack from being caused at the bonding portions of the two longitudinal ends of the capillary tube.

Abstract: There is provided an axial fan apparatus including an axial-flow impeller, a drive unit, and a housing. The axial-flow impeller is capable of rotating and includes a plurality of blades inclined with respect to a rotational axis direction. The drive unit rotates the axial-flow impeller. The housing is mounted with the drive unit, and includes a sidewall, and a plurality of slits that circulate gas. The sidewall is provided around the axial-flow impeller. The plurality of slits are provided to the sidewall and inclined with respect to the rotational axis direction in a direction opposed to a direction in which the plurality of blades incline.

Abstract: Provided is an axial fan apparatus including a housing and an axial-flow impeller. The axial-flow impeller is capable of rotating inside the housing and includes a plurality of axial-flow wings each having a negative pressure generation surface for generating a negative pressure, and an auxiliary vane standing on the negative pressure generation surface at an end portion of each of the plurality of axial-flow wings.