Abstract: A three-dimensional laser cutter can be disposed in a machining room. The machining room includes a ceiling and a plate member. The ceiling is provided with a suction port connected to a suction device. The plate member is disposed below the ceiling with a gap therebetween. The plate member forms a space with the ceiling.

Abstract: A steel material for sliding members with improved seizure resistance is provided. A steel material for sliding members has a chemical composition including, in mass %, 0.05 to 5.0% In, and a microstructure with metal In particles or particles of oxides mainly composed of In dispersed therein, those ones of the metal In particles which have diameters of 50 nm to 5 ?m being in a number density not lower than 5000 particles/mm2 or those ones of the particles of oxides mainly composed of In which have diameters not smaller than 1 ?m being in a number density not lower than 30 particles/mm2.

Abstract: A three-dimensional laser cutter can be disposed in a machining room. The machining room includes a ceiling and a plate member. The ceiling is provided with a suction port connected to a suction device. The plate member is disposed below the ceiling with a gap therebetween. The plate member forms a space with the ceiling.

Abstract: A Ni-based alloy tube includes a base metal having a chemical composition consisting, by mass percent, of C: 0.15% or less, Si: 1.0% or less, Mn: 2.0% or less, P: 0.030% or less, S: 0.030% or less, Cr: 10.0 to 40.0%, Ni: 50.0 to 80.0%, Ti: 0.50% or less, Cu: 0.60% or less, Al: 0.20% or less, N: 0.20% or less, and the balance: Fe and impurities; and a low Cr content complex oxide film having a thickness of 25 nm or smaller at least on an inner surface of the base metal, wherein contents of Al, Ni, Si, Ti, and Cr in the film satisfy [at % Al/at % Cr?2.00], [at % Ni/at % Cr?1.40], and [(at % Si+at % Ti)/at % Cr?0.10].

Abstract: A Ni-based alloy tube includes a base metal having a chemical composition consisting, by mass percent, of C: 0.15% or less, Si: 1.0% or less, Mn: 2.0% or less, P: 0.030% or less, S: 0.030% or less, Cr: 10.0 to 40.0%, Ni: 50.0 to 80.0%, Ti: 0.50% or less, Cu: 0.60% or less, Al: 0.20% or less, N: 0.20% or less, and the balance: Fe and impurities; and a low Cr content complex oxide film having a thickness of 25 nm or smaller at least on an inner surface of the base metal, wherein contents of Al, Ni, Si, Ti, and Cr in the film satisfy [at % Al/at % Cr?2.00], [at % Ni/at % Cr?1.40], and [(at % Si+at % Ti)/at % Cr?0.10].

Abstract: A method of cutting a cut member out of an original sheet by means of thermal cutting and machining, and includes a hole-cutting process, a finishing process, and an outer periphery-cutting process. During the hole-cutting process, a hole is created in the original sheet by means of thermal cutting while leaving a machining allowance in addition to the finished size of the hole. During the finishing process, a cutting tool is inserted into the hole which has been created through the hole-cutting process, and the cutting tool is guided along the inner circumference of the hole so as to cut the thermally-cut end surface in order to machine the hole to the finished size. During the outer periphery-cutting process, the outer periphery of the cut member is cut by means of thermal cutting to take the cut member out of the original sheet.

Abstract: A method of cutting a cut member out of an original sheet by means of thermal cutting and machining, and includes a hole-cutting process, a finishing process, and an outer periphery-cutting process. During the hole-cutting process, a hole is created in the original sheet by means of thermal cutting while leaving a machining allowance in addition to the finished size of the hole. During the finishing process, a cutting tool is inserted into the hole which has been created through the hole-cutting process, and the cutting tool is guided along the inner circumference of the hole so as to cut the thermally-cut end surface in order to machine the hole to the finished size. During the outer periphery-cutting process, the outer periphery of the cut member is cut by means of thermal cutting to take the cut member out of the original sheet.

Abstract: A method for manufacturing a Ni-based alloy article which elutes little Ni even when used in a high-temperature water environment for a long period comprises heating the Ni-based alloy in a carbon dioxide-containing atmosphere for a set period of time at an elevated temperature to form an oxide film comprising chromium oxide on a surface thereof. Using carbon dioxide as an oxidizing gas produces an oxide film of generally uniform thickness along a length of the article being treated so that resistance to nickel elution is more uniform over the entire article.

Abstract: To form a chromium oxide film on the inner surface of a Cr containing nickel-base alloy tube inexpensively and uniformly, the Cr containing nickel-base alloy tube is heated in atmospheric gas of carbon dioxide gas and non-oxidation gas to form an oxide film consisting of chromium oxide having a thickness of 0.2 to 1.5 ?m on the inner surface of the Cr containing nickel-base alloy tube. The atmospheric gas may contain oxygen gas of 5 vol % or less and/or water vapor of 7.5 vol % or less.

Abstract: A method for manufacturing a Ni-based alloy article which elutes little Ni even when used in a high-temperature water environment for a long period comprises heating the Ni-based alloy in a carbon dioxide-containing atmosphere for a set period of time at an elevated temperature to form an oxide film comprising chromium oxide on a surface thereof. Using carbon dioxide as an oxidizing gas produces an oxide film of generally uniform thickness along a length of the article being treated so that resistance to nickel elution is more uniform over the entire article.

Abstract: A method of heat treatment for an efficient forming of two-layered oxide film on the inside surface of a Ni-base alloy tube. The oxide film suppresses the Ni release in a high-temperature water environment. At least two gas supplying devices are provided on the outlet side of a continuous heat treatment furnace; or one gas supplying device is provided respectively on the outlet side and the inlet side thereof. The tube is put into the furnace while supplying an atmospheric gas into the tube from the front end of the tube moving direction with one of these gas supplying devices and a gas introducing pipe, which is arranged inside the furnace, and this tube is maintained at 650 to 1200° C. for 1 to 1200 minutes. The atmospheric gas consists of hydrogen or a mixture of hydrogen and argon, whose dew point is in a range of from ?60° C. to +20° C.

Abstract: A method of heat treatment for an efficient forming of two-layered oxide film on the inside surface of a Ni-base alloy tube. The oxide film suppresses the Ni release in a high-temperature water environment.

Abstract: A Ni-base heat resistant alloy excellent in weldability and strength at elevated temperatures and suited for use in manufacturing cracking furnace tubes and reformer furnace tubes to be used in ethylene plants as well as a welded joint therefor is provided. The alloy of the invention is a Ni-base heat-resistant alloy, which comprises C: not more than 0.1%, Si: not more than 2%, Mn: not more than 2%, P: not more than 0.025%, S: not more than 0.005%, N: not more than 0.04%, Cr: 10 to 30%, Al: 2.1 to less than 4.5%, and Mo: 2.5 to 15% or W: 2.5 to 9% or Mo and W: 2.5 to 15% in total, and satisfies the relation (1) given below: (104Si+1980P+1980S+9Al+15Ti+11Nb+1.8W+11600B)≦{1.

Abstract: The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) wherein one of R1 and R2 is hydrogen and the other is a group represented by wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.

Abstract: A Ni-base heat resistant alloy excellent in weldability and strength at elevated temperatures and suited for use in manufacturing cracking furnace tubes and reformer furnace tubes to be used in ethylene plants as well as a welded joint therefor is provided. The alloy of the invention is a Ni-base heat-resistant alloy, which comprises C: not more than 0.1%, Si: not more than 2%, Mn: not more than 2%, P: not more than 0.025%, S: not more than 0.005%, N: not more than 0.04%, Cr: 10 to 30%, Al: 2.1 to less than 4.5%, and Mo: 2.5 to 15% or W: 2.5 to 9% or Mo and W: 2.

Abstract: (1) A nickel-base alloy product having, on the surface thereof, an oxide film comprising at least two layers, namely a first layer mainly composed of Cr2O3 and having a chromium content of not less than 50% relative to the total amount of metal elements and a second layer occurring outside the first layer and mainly composed of MnCr2O4, wherein the grain size of Cr2O3 crystals in the first layer is 50 to 1,000 nm and the total oxide film thickness is 180 to 1,500 nm. (2) A method of producing the nickel-base alloy product as specified above under (1) which comprises subjecting a nickel-base alloy product to oxide film formation treatment by maintaining the same at a temperature of 650 to 1,200° C. in a hydrogen atmosphere or hydrogen-argon mixed atmosphere showing a dew point of −60° C. to +20° C. for 1 to 1,200 minutes.

Abstract: The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) 1

Abstract: The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by the following general formula (IX) and so on, as well as a biologically acceptable salt thereof wherein R16 represents —N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents —NH—, —O— or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.

Abstract: The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by the following general formula (IX) and so on, as well as a biologically acceptable salt thereof wherein R16 represents —N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents —NH—, —O— or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.

Abstract: Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) and quinione analogues derived therefrom (wherein R1 is alkyl, optionally substituted benzyl or optionally substituted aryl; R2 is hydrogen, alkyl, alkenyl or optionally substituted benzyl; R3 is hydrogen, alkyl, alkenyl, optionally substituted benzyl, hydroxyl, alkoxy, alkenyloxy or optionally substituted benzyloxy; R4 is hydrogen, alkyl, alkenyl, optionally substituted benzyl or hydroxyl; and R5 and R6 are each independently hydrogen, alkyl, alkenyl or optionally substituted benzyl). The polyhydroxyphenol derivatives and the quinone analogues exhibit a potent inhibitory activity against bone resorption and are useful as preventive and therapeutic agents for bone and cartilage diseases.