Patents by Inventor Kazuyuki Tomisawa
Kazuyuki Tomisawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6291467Abstract: An aromaheterocyclic derivative represented by the formula: wherein Z is a group represented by the following formula: wherein Ar1 is a phenyl group or a phenyl group substituted with a halogen atom or an alkyl group of 1 to 5 carbon atoms, R2 is an alkyl group of 1 to 5 carbon atoms, Y is a hydrogen atom, a mercapto group, an alkylthio group of 1 to 5 carbon atoms, an amino group or an amino group substituted with one or two alkyl groups having 1 to 5 carbon atoms, Ar2 is a phenyl group of one or two substituents selected from the group consisting of a halogen atom, an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms, a hydroxyl group and a trifluoromethyl group, or a phenyl group, B1-B2 is CH—CO or C═C(R1) (wherein R1 is a hydrogen atom or an alkyl group of 1 to 5 carbon atoms), and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof, which is a dopamine D4 receptor antagonist compound having an antipsychotic actioType: GrantFiled: September 15, 2000Date of Patent: September 18, 2001Assignees: Taisho Pharmaceutical Co., Ltd., Nihon Nohyaku Co. Ltd.Inventors: Atsuro Nakazato, Toshihito Kumagai, Shigeyuki Chaki, Kazuyuki Tomisawa, Masashi Nagamine, Makoto Gotoh, Masanori Yoshida
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Patent number: 6281355Abstract: A nitrogen-containing tetracyclic compound represented by the formula: wherein Y1—Y2—Y3 is N—C═N or a group represented by the formula: C═C—NR3 (wherein R3 is a hydrogen atom, a C1-5 alkyl group or a nitrogen-containing C2-10 alkyl group), Y4 is S, SO, SO2, CH2 or a group represented by the formula: NR4 (wherein R4 is a C1-5 alkanoyl group or a C1-5 alkyl group), R1 and R2 are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R1 and R2 taken together with the nitrogen atom to which they are attached form a cyclic amino group, X1 and X2 are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom, and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 1, 2000Date of Patent: August 28, 2001Assignees: Taisho Pharmaceutical Co., Ltd., Nihon Nohyaku Co., Ltd.Inventors: Atsuro Nakazato, Taketoshi Okubo, Toshihito Kumagai, Shigeyuki Chaki, Kazuyuki Tomisawa, Masashi Nagamine, Makoto Gotoh, Kuniaki Kondoh, Masanori Yoshida
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Patent number: 6187781Abstract: A 4-tetrahydropyridylpyrimidine compound represented by formula (I): wherein Ar represents a phenyl group substituted with 1 to 3 substituents selected from a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, and a trifluoromethyl group, a phenyl group, a thienyl group or a furanyl group; R1 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an amino group or an amino group substituted with 1 or 2 alkyl groups having 1 to 5 carbon atoms; R2 represents an alkyl group having 1 to 5 carbon atoms, a cycloalkylalkyl group having 4 to 7 carbon atoms, an alkenyl group having 2 to 5 carbon atoms or an alkynyl group having 2 to 5 carbon atoms; and X1, X2, and X3, which may be the same or different, each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an alkylthio group having 1 to 5 carbon atoms, an amino group or an amino group substituted with 1 orType: GrantFiled: September 21, 1999Date of Patent: February 13, 2001Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Toshihito Kumagai, Taketoshi Okubo, Izumi Aibe, Hideo Tanaka, Shigeyuki Chaki, Shigeru Okuyama, Kazuyuki Tomisawa
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Patent number: 6166033Abstract: This invention provides a 2-carbonylthiazole derivative represented by formula (I): ##STR1## wherein each of Ar.sup.1 and Ar.sup.2 represents a phenyl group or a substituted phenyl group; R.sup.1 represents an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group or an amino group; Y.sup.1 --Y.sup.2 represents CH--CO or C.dbd.CR.sup.2, wherein R.sup.2 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; and n is an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof. The disclosed compounds are useful as drugs for preventing and treating dopamine D receptor-related morbid states such as schizophrenia and problematic behavior caused by cerebrovascular accidents and senile dementia and do not induce extrapyramidal disorders as side effects.Type: GrantFiled: November 5, 1999Date of Patent: December 26, 2000Assignees: Taisho Pharmaceutical Co., Ltd., Nihon Nohyaku Co., Ltd.Inventors: Atsuro Nakazato, Toshihito Kumagai, Shigeyuki Chaki, Kazuyuki Tomisawa, Masashi Nagamine, Makoto Gotoh, Masanori Yoshida
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Patent number: 6162832Abstract: A 2-phenoxyaniline derivative represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkoxy group, R.sup.2 is a halogen atom or a nitro group, and R.sup.3 is a hydrogen atom or a halogen atom, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 10, 2000Date of Patent: December 19, 2000Assignee: Taisho Pharmaceutical Co., Inc.Inventors: Tomomi Ota, Misa Nakanishi, Izumi Aibe, Minoru Taguchi, Kazuyuki Tomisawa
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Patent number: 6156801Abstract: A 2-phenoxyaniline derivative represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, an amino group or an NHCOR.sup.3 group, R.sup.2 is a halogen atom, an amino group, a cyano group, a C.sub.1-6 alkyl group, a C.sub.1-3 perfluoroalkyl group, an NHCOR.sup.3 group, a CH.sub.2 OR.sup.4 group, an OCH.sub.2 R.sup.5 group or a COR.sup.6 group, R.sup.3 is a C.sub.1-6 alkyl group, R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sup.5 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-5 aminoalkyl group, a C.sub.2-7 alkoxy-carbonyl group or a carbamoyl group, and R.sup.6 is a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group which is unsubstituted or substituted by a halogen atom, an amino group, a cyano group or a straight or branched C.sub.1-6 alkyl group; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 15, 1999Date of Patent: December 5, 2000Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Tomomi Ota, Misa Nakanishi, Minoru Taguchi, Kazuyuki Tomisawa
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Patent number: 6066672Abstract: The present invention provides an amino compound represented by Formula: ##STR1## wherein X is CH.sub.2 NH or CONH, Y is CH.sub.2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH.dbd.C(R.sup.4)R.sup.5, CH.sub.2 CH(R.sup.4)R.sup.5 or an alkoxycarbonyl group, R.sup.1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R.sup.2 and R.sup.3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R.sup.4 and R.sup.Type: GrantFiled: July 16, 1998Date of Patent: May 23, 2000Assignees: Taisho Pharmaceutical Co., Ltd., Sagami Chemical Research CenterInventors: Takeo Kobori, Kenichi Goda, Kikuo Sugimoto, Tomomi Ota, Kazuyuki Tomisawa
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Patent number: 5484588Abstract: There are provided attracting and ingestion-stimulating agents for cockroach comprising as the active ingredient one or more compounds represented by the formula ##STR1## wherein R represents an amino group or an aminomethyl group. The attracting and ingestion-stimulating agents for cockroach exhibit a very potent attracting and ingestion-stimulating activity in the known species of house cockroach, both male and female.Type: GrantFiled: February 2, 1993Date of Patent: January 16, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kazumasa Ogino, Haruo Shimamura, Kazuyuki Tomisawa, Fumio Urushizaki, Masami Nemoto, Tuguchika Yoshida
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Patent number: 5116877Abstract: A cinnamamide derivative represented by the formula ##STR1## wherein X is a halogen atom is useful as a muscle relaxant.Type: GrantFiled: January 29, 1990Date of Patent: May 26, 1992Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Hironaka Aihara, Michio Kurachi, Kazuyuki Tomisawa
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Patent number: 4600540Abstract: Benzoylpropionic acid derivatives represented by the general formula ##STR1## (wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a benzyl group, R.sup.2 represents a lower alkyl group or a phenyl group, X represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a phenoxy group or a halogenophenoxy group, and Y represents a hydrogen atom or a lower alkyl group). The compounds have immunomodulative function and are effective for treatment of diseases caused by abnormal immunofunction.Type: GrantFiled: June 4, 1985Date of Patent: July 15, 1986Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kazuyuki Tomisawa, Kazuya Kameo, Toru Matsunaga, Shiuji Saito, Kaoru Sota
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Patent number: 4594197Abstract: 3-Benzoyl-2-mercaptopropionic acid derivatives represented by the general formula ##STR1## (wherein, X represents a hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group or a lower alkoxy group, Y represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, Z represents a hydrogen atom or an acyl group, and R represents a hydrogen atom or a lower alkyl group). These compounds have immunomodulative function and are effective for the treatment of diseases caused by abnormal immunofunction.Type: GrantFiled: August 31, 1984Date of Patent: June 10, 1986Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kazuyuki Tomisawa, Kazuya Kameo, Toru Matsunaga, Shiuji Saito, Yoshimoto Nakashima, Kaoru Sota
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Patent number: 4541959Abstract: Diphenylsulfide derivatives represented by the general formula ##STR1## wherein, X represents a hydrogen atom, a chlorine atom or a methyl group, and R represents a hydrogen atom or a lower alkyl group. These diphenyl sulfides reduce lipids such as cholesterols and triglycerides in the blood of mammals.Type: GrantFiled: August 29, 1984Date of Patent: September 17, 1985Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kazuyuki Tomisawa, Kazuya Kameo, Toru Matsunaga, Shiuji Saito, Yoshimoto Nakashima, Kaoru Sata
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Patent number: 4472316Abstract: Novel compounds having the general formula ##STR1## wherein X is hydrogen or halogen, Y is hydrogen, halogen, methoxy or alkyl having 1 to 3 carbon atoms, Z is hydrogen, alkylcarbonyl having 2 to 6 carbon atoms or benzoyl, and R is hydrogen, alkali metal or alkyl having 1 to 5 carbon atoms, are disclosed. These compounds exhibit excellent hypolipidemic activity and little or no side effect.Type: GrantFiled: February 23, 1983Date of Patent: September 18, 1984Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kaoru Sota, Yasuhide Tachi, Kazuyuki Tomisawa, Kazuya Kameo, Toru Matsunaga, Jiro Sawada