Patents by Inventor Keiji Itaka

Keiji Itaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220296632
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Application
    Filed: May 16, 2022
    Publication date: September 22, 2022
    Applicants: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi UCHIDA, Keiji ITAKA, Kazunori KATAOKA, Naoto YOSHINAGA
  • Patent number: 11364259
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: June 21, 2022
    Assignees: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Naoto Yoshinaga
  • Publication number: 20210260207
    Abstract: The present invention provides a polyion complex which can efficiently deliver mRNA into a living body as well as a therapeutic agent and a therapeutic method of arthropathy in which the polyion complex is used. For example, there is provided a polyion complex comprising a cationic polymer and mRNA, wherein the cationic polymer is a polymer comprising a cationic unnatural amino acid as a monomer unit and the cationic unnatural amino acid is an amino acid having a group represented by —(NH—(CH2)2)p—NH2, wherein p is 2, 3 or 4, as a side chain.
    Type: Application
    Filed: April 26, 2021
    Publication date: August 26, 2021
    Applicant: NanoCarrier Co., Ltd.
    Inventors: Keiji ITAKA, Shinsuke OHBA, Yuichi TEI, Kazunori KATAOKA
  • Publication number: 20190328769
    Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.
    Type: Application
    Filed: December 27, 2017
    Publication date: October 31, 2019
    Applicants: THE UNIVERSITY OF TOKYO, KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Satoshi UCHIDA, Keiji ITAKA, Kazunori KATAOKA, Naoto YOSHINAGA
  • Patent number: 10232054
    Abstract: A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 19, 2019
    Assignee: AccuRna, Inc.
    Inventors: Kazunori Kataoka, Keiji Itaka, Takehiko Ishii, Hirokuni Uchida, Satoshi Uchida, Miyuki Baba
  • Publication number: 20190008980
    Abstract: The present invention provides a polyion complex which can efficiently deliver mRNA into a living body as well as a therapeutic agent and a therapeutic method of arthropathy in which the polyion complex is used. For example, there is provided a polyion complex comprising a cationic polymer and mRNA, wherein the cationic polymer is a polymer comprising a cationic unnatural amino acid as a monomer unit and the cationic unnatural amino acid is an amino acid having a group represented by —(NH—(CH2)2)p—NH2, wherein p is 2, 3 or 4, as a side chain.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 10, 2019
    Applicant: AccuRna, Inc.
    Inventors: Keiji ITAKA, Shinsuke OHBA, Yuichi TEI, Kazunori KATAOKA
  • Publication number: 20170183389
    Abstract: The present invention provides a method for improving protein expression and a composition for protein expression. The composition is a composition for use in expressing a target protein, the composition comprising an mRNA encoding the target protein, wherein 80% or more of the mRNA molecules contained in the composition have a sequence consisting substantially of poly(A) having a length of 230 to 250 nucleotides on the 3?-end side of the protein-coding region thereof.
    Type: Application
    Filed: April 23, 2015
    Publication date: June 29, 2017
    Applicant: ACCURNA, INC.
    Inventors: Keiji ITAKA, Kazunori KATAOKA, Masaru IKEGAMI, Satoshi UCHIDA, Hirokuni UCHIDA, Kazuya NAGATA
  • Publication number: 20170173182
    Abstract: A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 22, 2017
    Applicant: AccuRna, Inc.
    Inventors: Kazunori KATAOKA, Keiji ITAKA, Takehiko ISHII, Hirokuni UCHIDA, Satoshi UCHIDA, Miyuki BABA
  • Patent number: 9314529
    Abstract: An excellent nucleic acid delivery composition is provided which has reduced cytotoxicity and improved nucleic acid introduction efficiency and gene expression efficiency. The composition comprises: a block copolymer having an uncharged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid, wherein the mol percentage (B/H ratio) of the cationic groups of the block copolymer to the total cationic groups of the block copolymer and the cationic polymer is between 25% and 90%.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: April 19, 2016
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Takehiko Ishii, Kensuke Osada, Qixian Chen, Keiji Itaka, Satoshi Uchida
  • Patent number: 8791086
    Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: July 29, 2014
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Shourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Hiroyuki Koyama, Takuya Hashimoto, Yuichi Tei
  • Patent number: 8445279
    Abstract: Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells. This invention, the 3D spheroid cultured construction for MSCs, leads to great improve of the differentiation efficiency. This invention relates to a cultured cell construct comprising a support; at least one island on the support; a hydrophilic and cytophobic substance applied on the surface of said support so as to encircle the island; and a spheroid which is derived from MSCs, said spheroid being in contact with the island.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: May 21, 2013
    Assignee: Transparent Inc.
    Inventors: Wenjie Wang, Keiji Itaka, Shinsuke Ohba, Nobuhiro Nishiyama, Ung-il Chung, Yuichi Yamasaki, Kazunori Kataoka
  • Publication number: 20130109743
    Abstract: An excellent nucleic acid delivery composition is provided which has reduced cytotoxicity and improved nucleic acid introduction efficiency and gene expression efficiency. The composition comprises: a block copolymer having an uncharged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid, wherein the mol percentage (B/H ratio) of the cationic groups of the block copolymer to the total cationic groups of the block copolymer and the cationic polymer is between 25% and 90%.
    Type: Application
    Filed: July 11, 2011
    Publication date: May 2, 2013
    Applicant: The University of Tokyo
    Inventors: Kazunori Kataoka, Takehiko Ishii, Kensuke Osada, Qixian Chen, Keiji Itaka, Satoshi Uchida
  • Patent number: 8318205
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: November 27, 2012
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
  • Publication number: 20120177594
    Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.
    Type: Application
    Filed: July 22, 2010
    Publication date: July 12, 2012
    Inventors: Kazunori Kataoka, Shourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Hiroyuki Koyama, Takuya Hashimoto, Yuichi Tei
  • Patent number: 7829657
    Abstract: Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: November 9, 2010
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Keiji Itaka, Nobuhiro Nishiyama, Shigeto Fukushima, Woo-Dong Jang, Kanjiro Miyata, Masataka Nakanishi, Shunsaku Asano, Naoki Kanayama
  • Patent number: 7780957
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 24, 2010
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
  • Publication number: 20100137512
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Application
    Filed: January 25, 2010
    Publication date: June 3, 2010
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
  • Publication number: 20100099190
    Abstract: Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells. This invention, the 3D spheroid cultured construction for MSCs, leads to great improve of the differentiation efficiency. This invention relates to a cultured cell construct comprising a support; at least one island on the support; a hydrophilic and cytophobic substance applied on the surface of said support so as to encircle the island; and a spheroid which is derived from MSCs, said spheroid being in contact with the island.
    Type: Application
    Filed: October 21, 2008
    Publication date: April 22, 2010
    Applicant: Transparent Inc.
    Inventors: Wenjie WANG, Keiji Itaka, Shinsuke Ohba, Nobuhiro Nishiyama, Ung-il Chung, Yuichi Yamasaki, Kazunori Kataoka
  • Publication number: 20080249049
    Abstract: A composition for the delivery of nucleic acid to target cells or tissues, which comprises polycationically charged polymer as a carrier of nucleic acid is provided. Said polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to said main chain either directly or via a linker. This composition is low-toxic, and has a high efficiency in introducing nucleic acid into cells.
    Type: Application
    Filed: February 8, 2006
    Publication date: October 9, 2008
    Inventors: Kazunori Kataoka, Keiji Itaka, Nobuhiro Nishiyama, Shigeto Fukushima, Woo-Dong Jang, Kanjiro Miyata, Masataka Nakanishi, Shunsaku Asano, Naoki Kanayama
  • Publication number: 20070059271
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Application
    Filed: May 7, 2004
    Publication date: March 15, 2007
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada