Patents by Inventor Keiko Fukushima

Keiko Fukushima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for analyzing PSA and method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA
    Patent number: 10866240
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for p-N-acetylgalactosamine residues and/or a lectin having an affinity for fucose a(I, 2) galactose residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: December 15, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Katsuko Yamashita, Keiko Fukushima, Shiro Baba, Takefumi Satoh
  • Method for analyzing PSA, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA
    Patent number: 10196694
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: February 5, 2019
    Assignees: TOKYO INSTITUTE OF TECHNOLOGY, KONICA MINOLTA, INC.
    Inventors: Katsuko Yamashita, Keiko Fukushima
  • METHOD FOR ANALYZING PSA, AND A METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA
    Publication number: 20160138118
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Application
    Filed: January 25, 2016
    Publication date: May 19, 2016
    Applicants: TOKYO INSTITUTE OF TECHNOLOGY, KONICA MINOLTA HOLDINGS, INC.
    Inventors: Katsuko Yamashita, Keiko Fukushima
  • Method for analyzing PSA, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA
    Patent number: 9285368
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: March 15, 2016
    Assignees: TOKYO INSTITUTE OF TECHNOLOGY, KONICA MINOLTA HOLDINGS, INC.
    Inventors: Katsuko Yamashita, Keiko Fukushima
  • 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of inflammatory or immunological disorders
    Patent number: 9206186
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: December 8, 2015
    Assignee: AXIKIN PHARMACEUTICALS, INC.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • 2-Phenoxy- and 2-Phenylsulfonamide Derivatives with CCR3 Antagonistic Activity for the Treatment of Inflammatory or Immunological Disorders
    Publication number: 20140005176
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 2, 2014
    Applicant: AXIKIN PHARMACEUTICALS, INC.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • METHOD FOR DETECTING GASTRIC CANCER
    Publication number: 20130130276
    Abstract: The object of the present invention is to provide a method for detecting gastric cancer, and a kit for detecting gastric cancer. The object can be solved by a method for detecting gastric cancer characterized by analyzing ?1,4-N-acetylgalactosamine transferase 1. According to the present invention, gastric cancer patients can be detected at high rates, even early stage gastric cancer patients without a subjective symptom.
    Type: Application
    Filed: May 17, 2011
    Publication date: May 23, 2013
    Applicants: School Juridical Person Kitasato Institute, Tokyo Institute of Technology
    Inventors: Katsuko Yamashita, Keiko Fukushima, Masahiko Watanabe, Keishi Yamashita
  • METHOD FOR ANALYZING MUCIN 1 HAVING SIAALPHA2-8SIAALPHA2-3GALBETA GLYCANS
    Publication number: 20130115612
    Abstract: The object of the present invention is to provide a clinical marker capable of distinguishing breast cancer from interstitial pneumonia; and a clinical marker for detecting malignancy or progress level of breast cancer, and for monitoring effects of the treatment of breast cancer. The object can be solved by a method for analyzing mucin 1 having Sia?2-8Sia?2-3Gal?-R, characterized by comprising the step of bringing a first probe specifically binding to a mucin 1 having Sia?2-8Sia?2-3Gal?-R into contact with a sample to be tested.
    Type: Application
    Filed: May 6, 2011
    Publication date: May 9, 2013
    Applicants: YAMAGUCHI UNIVERSITY, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Katsuko Yamashita, Keiko Fukushima, Yuji Hinoda
  • METHOD FOR ANALYZING PSA, AND A METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA
    Publication number: 20120282612
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Application
    Filed: March 4, 2010
    Publication date: November 8, 2012
    Applicants: Konica Minolta Holdings, Inc., Tokyo Institute of Technology
    Inventors: Katsuko Yamashita, Keiko Fukushima
  • Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders
    Patent number: 8242118
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 14, 2012
    Assignee: Axikin Pharmaceuticals Inc.
    Inventors: Yingfu Li, Akihiko Watanabe, Timothy B. Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Fukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino
  • METHOD FOR ANALYZING PSA AND METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA
    Publication number: 20110294141
    Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues and/or a lectin having an affinity for fucose ?(1, 2) galactose residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.
    Type: Application
    Filed: February 4, 2010
    Publication date: December 1, 2011
    Inventors: Katsuko Yamashita, Keiko Fukushima, Shiro Baba, Takefumi Satoh
  • Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders
    Patent number: 7700586
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: April 20, 2010
    Assignee: Axikin Pharmaceuticals, Inc.
    Inventors: Yingfu Li, Akihiko Watanabe, Timothy B. Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Fukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino
  • 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders
    Patent number: 7674797
    Abstract: The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: March 9, 2010
    Assignee: Axikin Pharmaceuticals, Inc.
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • 2-Phenoxy- and 2-Phenylsulfonamide Derivatives with CCR3 Antagonistic Activity for the Treatment of Inflammatory or Immunological Disorders
    Publication number: 20090286771
    Abstract: Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
    Type: Application
    Filed: July 16, 2009
    Publication date: November 19, 2009
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • Optically active pyridine derivative and a medicament containing the same
    Publication number: 20090054424
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula: or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 26, 2009
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger
  • Optically active pyridine derivative and a medicament containing the same
    Patent number: 7375103
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: May 20, 2008
    Assignee: Bayer HealthCare AG
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger
  • 2-Phenoxy- and 2-phenylsulfomamide derivatives with ccr3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders
    Publication number: 20070155725
    Abstract: The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
    Type: Application
    Filed: March 11, 2004
    Publication date: July 5, 2007
    Inventors: Yingfu Li, Kevin Bacon, Hiromi Sugimoto, Keiko Fukushima, Kentaro Hashimoto, Makiko Marumo, Toshiya Moriwaki, Noriko Nunami, Naoki Tsuno, Klaus Urbahns, Nagahiro Yoshida
  • Optically active pyridine derivative and a medicament containing the same
    Publication number: 20050215547
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]?-azin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
    Type: Application
    Filed: March 3, 2003
    Publication date: September 29, 2005
    Applicant: Bayer HealthCare AG
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger
  • Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders
    Publication number: 20050070582
    Abstract: The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
    Type: Application
    Filed: September 4, 2002
    Publication date: March 31, 2005
    Applicant: Bayer Healthcare AG
    Inventors: Yingfu Li, Akihiko Watanabe, Timothy Lowinger, Kevin Bacon, Norihiro Kawamura, Takuya Shintani, Tetsuo Kikuchi, Toshiya Moriwaki, Klaus Urbahns, Keiko Fukushima, Noriko Nunami, Takashi Yoshino, Toshiki Murata, Megumi Yamauchi, Hiroko Yoshino