Patents by Inventor Keith A. M. Walker

Keith A. M. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4213991
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is phenethyl and R.sup.2 is phenyl, each of said phenethyl or phenyl independently being unsubstituted or substituted in the phenyl ring by from 1 to 3 substituents selected from the group consisting of halo, lower alkyl and lower alkoxy with the proviso that at least one of R.sup.1 and R.sup.2 be substituted by lower alkoxy; X is oxygen or sulfur; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: July 22, 1980
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4172141
    Abstract: Compounds of the formula ##STR1## wherein R is alkyl, benzyl, substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with from one to three substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; X is oxygen or sulfur; and the pharmaceutically acceptable acid addition salts thereof are CNS-active agents, inhibitors of gastric secretion and antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: October 23, 1979
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4150153
    Abstract: Compounds of the formula ##STR1## wherein Z is hydroxymethylene, esterified hydroxymethylene, carbonyl, or ketal-, thioketal- or hemithioketal- protected carbonyl, and the pharmaceutically acceptable acid addition salts thereof, are useful as anticonvulsant and anti-secretory agents.
    Type: Grant
    Filed: November 4, 1977
    Date of Patent: April 17, 1979
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4123542
    Abstract: Compounds of the formula ##STR1## wherein R is lower alkyl; R.sup.1 is substituted or unsubstituted phenyl or phenyl straight chain lower alkyl; R.sup.2 is substituted or unsubstituted phenyl, phenyl straight chain lower alkyl or phenyl straight chain lower alkenyl; and wherein said substitution, solely in the phenyl ring of the aforesaid groups, comprises one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo and trifluoromethyl; X is oxygen or sulfur; n is an integer of from 1 to 4 with the proviso that n cannot be 1 when X is oxygen and R.sup.1 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: October 31, 1978
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4078071
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently phenyl, phenyl straight chain lower alkyl or phenyl straight chain lower alkenyl or one of the above substituted in the phenyl ring with one or more substituents independently selected from the group consisting of lower alkyl of from one to four carbon atoms, halo and trifluoromethyl; X is oxygen or sulfur; n is an integer of from 1 to 8 with the proviso that n is not 1 when R.sup.1 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: March 7, 1978
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4059705
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently alkyl, cyclohexyl substituted with from one to three lower alkyl groups, or a group of the formula ##STR2## WHEREIN M IS AN INTEGER OF FROM 0 TO 3 AND P IS AN INTEGER OF FROM 1 TO 3; X is sulfur or oxygen; n is an integer of from 1 to 8; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: November 22, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4055652
    Abstract: Novel 1-[.beta.-(R-thio)phenethyl]-imidazoles and the corresponding 1-[.beta.-(R-sulfinyl)phenethyl]imidazoles and 1-[.beta.-(R-sulfonyl)phenethyl]imidazoles wherein R is alkyl, alkenyl, aralkenyl, substituted aralkenyl, alkynyl, cycloalkyl, cycloalkyl alkyl, aralkyl, substituted aralkyl, aryl or substituted aryl; and the antimicrobial acid addition salts thereof, are useful as antifungal, anti-bacterial and anti-protozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: October 25, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4045568
    Abstract: Compounds of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is phenyl, phenyl straight chain lower alkyl or phenyl straight chain lower alkenyl or one of the above substituted in the phenyl ring with one or more substituents independently selected from the group consisting of lower alkyl of from one to four carbon atoms, halo and trifluoromethyl; the other of R.sup.1 and R.sup.2 is alkyl, cyclohexyl, cyclohexyl lower alkyl or cyclohexyl substituted with from 1 to 3 lower alkyl groups; X is oxygen or sulfur; n is an integer of from 1 to 8 with the proviso that n is not 1 when R.sup.1 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: August 30, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4039677
    Abstract: Novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole ring by an optionally substituted hydrocarbyl carbonate or a mono-, di-, or trithiocarbonate are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole with a mercapto. Both the former and latter compounds are useful as intermediates in the preparation of certain 1-[.beta.-(R-thio)phenethyl]imidazoles.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: August 2, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Patent number: 4038409
    Abstract: Novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole ring by an optionally substituted hydrocarbyl ester, thioester, or dithioester are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the position .beta. to the imidazole with a mercapto. Both the former and latter compounds are useful as intermediates in the preparation of certain 1-[.beta.-(R-thio)phenethyl] imidazoles.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: July 26, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036973
    Abstract: Compounds of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is alkyl or the group ##STR2## IN WHICH N IS 0 TO 3 AND THE OTHER OF R.sup.1 and R.sup.2 is benzyl, substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with one or more substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; X and Y are independently oxygen or sulfur with the proviso that Y is not oxygen when R.sup.2 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036970
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently benzyl substituted benzyl, phenyl or substituted phenyl, said substituted benzyl and substituted phenyl substituted on the phenyl ring with one or more substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; X and Y are independently oxygen or sulfur with the proviso that Y is not oxygen when R.sup.2 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036974
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl or the group ##STR2## IN WHICH N IS 0 TO 3; X and Y are independently oxygen or sulfur; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Keith A. M. Walker, Michael Marx
  • Patent number: 4036975
    Abstract: Compounds of the formula ##STR1## wherein R is alkyl, cycloalkyl, cycloalkyl lower alkyl, phenyl or phenyl lower alkyl, said phenyl and phenyl lower alkyl optionally substituted on the phenyl ring with one or more substituents independently selected from the group consisting of halo, lower alkyl and trifluoromethyl; and X is oxygen or sulfur with the proviso that X is not oxygen when R is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: July 19, 1977
    Assignee: Xyntex (U.S.A) Inc.
    Inventors: Keith A. M. Walker, Stefan Howard Unger