Patents by Inventor Keith G. Tomazi

Keith G. Tomazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8946433
    Abstract: The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: February 3, 2015
    Assignee: Mallinckrodt LLC
    Inventors: Brian Orr, Joseph P. Haar, Jr., George H. Klemm, Keith G. Tomazi
  • Patent number: 8629301
    Abstract: The present invention relates to the economical and separation of benzphetamine hydrochloride and methamphetamine by liquid extraction. An extraction process employing a suitable organic solvent and water at a pH in the range of from about 6 to about 8 provides excellent removal of the methamphetamine by dissolution in the water phase while the benzphetamine dissolves in the organic phase. Simple separation of the two phases results in separation of the two amines.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: January 14, 2014
    Assignee: Mallinckrodt LLC
    Inventor: Keith G. Tomazi
  • Patent number: 8394814
    Abstract: The invention provides a method for separating noscapine from an opium source without substantially changing the color of the noscapine.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: March 12, 2013
    Assignee: Mallinekrodt LLC
    Inventors: Benjamin M. Marshall, Keith G. Tomazi
  • Patent number: 8232397
    Abstract: The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Brenda E. Allen, Esa T. Jarvi, Dennis J. Kalota, James R. Meyer, Keith G. Tomazi, Anthony Mannino, Brian Orr
  • Publication number: 20120071659
    Abstract: The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 22, 2012
    Applicant: Mallinckrodt LLC
    Inventors: Brian ORR, Joseph P. HAAR, JR., George H. KLEMM, Keith G. TOMAZI
  • Patent number: 7750187
    Abstract: There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: July 6, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Dennis J. Kalota, Keith G. Tomazi
  • Publication number: 20100113831
    Abstract: A highly pure crystalline form of benzphetamine hydrochloride and methods for the purification and crystallization of benzphetamine hydrochloride in high yield are disclosed.
    Type: Application
    Filed: October 17, 2006
    Publication date: May 6, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Keith G. Tomazi, Gary A. Nichols, Michelle R. Menze, Dennis J. Kalota
  • Publication number: 20100087647
    Abstract: The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Brenda E. Allen, Esa T. Jarvi, Dennis J. Kalota, James R. Meyer, Keith G. Tomazi, Anthony Mannino, Brian Orr
  • Publication number: 20100081822
    Abstract: The invention provides a method for separating noscapine from an opium source without substantially changing the color of the noscapine.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Benjamin M. Marshall, Keith G. Tomazi
  • Publication number: 20090275754
    Abstract: A process for purifying Narcotine to remove color and impurities to form Noscapine. The process includes forming an aqueous isopropanol solution with the Narcotine product wherein the isopropanol concentration of the solution is about 20% to about 70% by volume; and adjusting the pH of the solution with a strong base to a pH of about 10 to about 14, wherein impurities are removed from the Narcotine product.
    Type: Application
    Filed: March 28, 2007
    Publication date: November 5, 2009
    Inventors: Keith G. Tomazi, Leroy Love, JR., Joseph P. Haar, JR.
  • Publication number: 20090124833
    Abstract: The present invention relates to the economical and separation of benzphetamine hydrochloride and methamphetamine by liquid extraction. An extraction process employing a suitable organic solvent and water at a pH in the range of from about 6 to about 8 provides excellent removal of the methamphetamine by dissolution in the water phase while the benzphetamine dissolves in the organic phase. Simple separation of the two phases results in separation of the two amines.
    Type: Application
    Filed: November 2, 2005
    Publication date: May 14, 2009
    Applicant: MALLINCKRODT INC.
    Inventor: Keith G. Tomazi
  • Patent number: 7495098
    Abstract: A method for extracting at least one alkaloid from opium that includes dissolving opium in a solvent, heating the dissolved opium solution, cooling the dissolved opium solution, adjusting the pH of the dissolved opium solution with at least one first weak acid, filtering the dissolved opium solution to recover a filtrate; and then separating and purifying at least one alkaloid in the filtrate. Preferably, this includes an additional step of chilling the opium solution after adjusting the pH of the dissolved opium solution with at least one first acid. The preferred method for separating and purifying at least one alkaloid in the filtrate includes utilizing preparative liquid chromatography, however, solvent extraction and filtration can also be utilized.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: February 24, 2009
    Assignee: Mallinckrodt Inc
    Inventor: Keith G. Tomazi
  • Publication number: 20080262268
    Abstract: There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation.
    Type: Application
    Filed: November 2, 2005
    Publication date: October 23, 2008
    Inventors: Dennis J. Kalota, Keith G. Tomazi