Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: An implantable medical device with a reservoir including a movable reservoir member, a fill port in fluid communication with the reservoir, and a valve that includes a housing including an opening in fluid communication with the fill port and the reservoir and a valve seat adjacent to the opening, and a valve element, operably connected to the movable reservoir member, that is movable relative to the valve seat between a closed position and an open. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: A fluid transfer device with a fluid transfer device housing, including a bore and a valve seat that extends around the bore, configured to be carried within the implantable medical device, a piston located within the bore, and a valve element movable relative to the valve seat. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same. The valves may include a valve seat and a valve element, and be configured such that one of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in a closed position.

Abstract: Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: An ambulatory medical device including a reservoir, a fluid transfer device operably connected to the reservoir, and a pressure regulator that has a valve seat and a valve element movable between a closed position where the valve element engages the valve seat and prevents fluid flow and an open position where the valve element is in spaced relation to the valve seat and does not prevent fluid flow. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is engaged by the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: Systems and methods are disclosed for streaming of audio data of separate streams in at least two different formats. In some embodiments handheld game devices are in wireless communication and a first of the handheld game devices streams audio data during game play to a second of the handheld game devices. In some embodiments the audio data includes audio data from a plurality of streams of audio data. In some embodiments the streams of audio data include streams of audio data in different formats, generally different compressed formats, some of which may be selected based on whether a device includes circuitry specifically configured to decompress audio data in a specific data format.

Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.

Abstract: A handheld video game system provides a music video game including a guitar simulation. Operation of the handheld video game system is designed to simulate, to a certain extent, the playing of a real guitar. The handheld video game system typically includes a touch sensitive screen, whereby certain actuation and stroke motions made along the surface of the touch sensitive screen are processed by the handheld video game system as simulated guitar strums. Sets of criteria are implemented by the handheld video game system to determine whether a particular stroke motion is processed and registered as a valid strum.

Abstract: Systems and methods are disclosed for streaming of audio data of separate streams in at least two different formats. In some embodiments handheld game devices are in wireless communication and a first of the handheld game devices streams audio data during game play to a second of the handheld game devices. In some embodiments the audio data includes audio data from a plurality of streams of audio data. In some embodiments the streams of audio data include streams of audio data in different formats, generally different compressed formats, some of which may be selected based on whether a device includes circuitry specifically configured to decompress audio data in a specific data format.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same. The valves includes a valve element and a valve seat, and one of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion.

Abstract: A catheter for use in delivery or withdrawal of a formulation, wherein the catheter has an outer layer comprising a bio-compatible material and a barrier layer comprising a material that provides a more effective barrier than the outer layer against inward and outward diffusion of substances that may cause destabilization of the formulation. The catheter may include a flared distal end tip to aid in the release, during a bolus delivery or catheter flush, of any obstruction situated at the distal end tip of the catheter. The catheter may also include a slit valve at the distal end tip which has one or more and, preferably a plurality of slits that may be elastically extended to an open position by the expulsion of the formulation during an IIP pump stroke. During the interval between IIP pump strokes, the slits return to a closed position and hinder the inflow of body fluid into the distal end tip.

Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.

Abstract: Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.

Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.

Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.