Abstract: A wireless surgical loupe enables a user to use the wireless loupe to perform a procedure, transmit information acquired by the wireless loupe and display patient information on a wireless loupe display. The transmitted information is able to be used to aid the operating room procedure, enhance education and be recorded for later use.

Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.

Abstract: A feeding tube assembly having a feeding tube, an imaging assembly having a rigid axis and a bending axis transversely oriented relative to the rigid axis is disclosed. The imaging assembly can be preferentially deformable along the bending axis relative to the rigid axis. A marking disposed on at least one of the imaging assembly and the feeding tube can provide an indication of the bending axis. A packaging comprising a curvilinear cavity and a circular cavity can respectively contain the imaging assembly and the feeding tube, in a coiled configuration, which induces the feeding tube assembly into a pre-set, arcuate shape.

Abstract: A feeding tube assembly having a feeding tube, an imaging assembly having a rigid axis and a bending axis transversely oriented relative to the rigid axis is disclosed. The imaging assembly can be preferentially deformable along the bending axis relative to the rigid axis. A marking disposed on at least one of the imaging assembly and the feeding tube can provide an indication of the bending axis. A packaging comprising a curvilinear cavity and a circular cavity can respectively contain the imaging assembly and the feeding tube, in a coiled configuration, which induces the feeding tube assembly into a pre-set, arcuate shape.

Abstract: A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Abstract: A technique for incorporating odor control agent particles into an absorbent article is provided. More specifically, the odor control particles are “homogenously” distributed (e.g., in a substantially uniform manner) within an airformed fiber matrix of an absorbent core of an absorbent article. An absorbent core containing such a homogeneously distributed odor control particles may possess a greater surface area for contacting malodorous compounds, thereby increasing the likelihood of odor reduction.

Abstract: A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.

Abstract: In one example, a mixing header includes a body that defines a fluid passage having an inlet side and an outlet side. The mixing header also includes a flow conditioning element that is connected to the body and arranged for fluid communication with the fluid passage. The flow conditioning element also includes a plurality of elements each connected to, and extending outwardly from, a hub.

Abstract: A wireless surgical loupe enables a user to use the wireless loupe to perform a procedure, transmit information acquired by the wireless loupe and display patient information on a wireless loupe display. The transmitted information is able to be used to aid the operating room procedure, enhance education and be recorded for later use.

Abstract: A feeding tube assembly having a feeding tube, an imaging assembly having a rigid axis and a bending axis transversely oriented relative to the rigid axis is disclosed. The imaging assembly can be preferentially deformable along the bending axis relative to the rigid axis. A marking disposed on at least one of the imaging assembly and the feeding tube can provide an indication of the bending axis. A packaging comprising a curvilinear cavity and a circular cavity can respectively contain the imaging assembly and the feeding tube, in a coiled configuration, which induces the feeding tube assembly into a pre-set, arcuate shape.

Abstract: The present invention features, inter alia, compositions and methods for the treatment of cancer and infectious disease. The compositions include engineered proteins that specifically bind a metal chelate and may be bispecific. For example, the engineered proteins may bind (a) a target (e.g., a cellular protein) on a cancerous cell or a pathogen and (b) a metal chelate comprising DOTA, or an active variant thereof, and a metal ion such as a radionuclide. By virtue of the multiple binding sites, the engineered protein effectively delivers a metal chelate to a cell one wishes to destroy.

Abstract: In one example, a mixing header includes a body that defines a fluid passage having an inlet side and an outlet side. The mixing header also includes a flow conditioning element that is connected to the body and arranged for fluid communication with the fluid passage. The flow conditioning element also includes a plurality of elements each connected to, and extending outwardly from, a hub.

Abstract: In one example, a fluid system component includes a first element and a second element, where one or both of the first and second elements are configured to be exposed to a fluid. The fluid system also includes a flexible diaphragm positioned between the first and second elements. Finally, the fluid system component includes one or more retaining elements, each retaining element having a first portion received in the first element and a second portion received in the second element. The retaining elements also extend through the flexible diaphragm.

Abstract: A cleansing composition is disclosed that changes color during use. The cleansing composition contains a plurality of thermochromic dyes that cause a color change to occur at a threshold temperature and continue to cause a color change over a temperature range. The range of temperatures corresponds to approximately the amount of time sufficient to properly wash or scrub using the product.