Patents by Inventor Kelvin W. Gee

Kelvin W. Gee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAreceptors
    Patent number: 8865719
    Abstract: The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: October 21, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS
    Publication number: 20120077816
    Abstract: The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
    Type: Application
    Filed: March 9, 2010
    Publication date: March 29, 2012
    Inventors: Timothy B.C. Johnstone, Dark J. Hogenkamp, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7825278
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: November 2, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7820663
    Abstract: The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: October 26, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof
    Publication number: 20080176897
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: February 15, 2008
    Publication date: July 24, 2008
    Inventors: Timothy B.C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
    Patent number: 7355047
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: April 8, 2008
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Publication number: 20080064748
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: May 5, 2005
    Publication date: March 13, 2008
    Inventors: Derk J. Hogenkamp, Timothy B.C. Johnstone, Kelvin W. Gee
  • Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
    Patent number: 5591733
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: January 7, 1997
    Assignee: University of Southern California
    Inventors: Michael B. Bolger, Kelvin W. Gee, Nancy C. Lan, Robert H. Purdy, Seid Mirsadeghi, Syed Hasan Tahir, Delia Belelli
  • Use of peripheral-type benzodiazpine sites for treatment of CNS trauma or disease
    Patent number: 5550124
    Abstract: It is a purpose of this invention to provide a means of treating various central nervous system (CNS) injuries to prevent or minimize damage to the CNS. A novel use has been found for some previously known compounds which are inhibitory agonists of the peripheral-type BZ receptors.It is another purpose of this invention to provide a means of speeding the recovery of tissue damaged through injury to the CNS. The above described inhibitory agonists of the peripheral-type BZ receptors are useful for this purpose, and provide an easily administrable medication.Additionally, a means is provided for screening for new compounds which will act as inhibitory agonists of the peripheral-type BZ receptors and therefore which can be used for treating CNS injuries and for speeding the recovery of tissue damaged through such injuries.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: August 27, 1996
    Assignee: University of Southern California
    Inventor: Kelvin W. Gee
  • Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
    Patent number: 5232917
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: August 3, 1993
    Assignee: University of Southern California
    Inventors: Michael Bolger, Kelvin W. Gee, Nancy C. Lan, Delia Belelli, Seid Mirsadeghi, Robert Purdy
  • Method, compositions, and compounds for modulating brain excitability
    Patent number: 5208227
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionophore (GBR) complex.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: May 4, 1993
    Assignee: University of Southern California
    Inventors: Kelvin W. Gee, Michael B. Bolger, Roberta E. Brinton, Deborah J. Burke, Bruce S. McEwen
  • Method, compositions, and compounds for modulating brain excitability
    Patent number: 5120723
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
    Type: Grant
    Filed: May 10, 1990
    Date of Patent: June 9, 1992
    Assignee: University of Southern California
    Inventors: Kelvin W. Gee, Michael B. Bolger
  • Method, compositions, and compounds for modulating brain excitability
    Patent number: RE35517
    Abstract: Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: May 20, 1997
    Assignee: University of Southern California
    Inventors: Kelvin W. Gee, Michael B. Bolger, Nancy C. Lan