Patents by Inventor Kendall Carey

Kendall Carey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ASSAYING T-CELL DEPENDENT BISPECIFIC ANTIBODIES
    Publication number: 20230280355
    Abstract: The present invention provides a cell-based assay for measuring T cell activation mediated by a T cell-dependent bispecific antibody (TDB). In some aspects, the assay is useful for detecting a TDB in a composition, quantitating the amount of TDB in a composition, determining the potency and/or specificity of a TDB, or determining if a population of cells expresses a target antigen. Compositions and kits are also contemplated.
    Type: Application
    Filed: October 14, 2022
    Publication date: September 7, 2023
    Inventors: Ho Young LEE, Guoying JIANG, Pin Yee WONG, Kendall CAREY
  • Methods for assaying T-cell dependent bispecific antibodies
    Patent number: 11513127
    Abstract: The present invention provides a cell-based assay for measuring T cell activation mediated by a T cell-dependent bispecific antibody (TDB). In some aspects, the assay is useful for detecting a TDB in a composition, quantitating the amount of TDB in a composition, determining the potency and/or specificity of a TDB, or determining if a population of cells expresses a target antigen. Compositions and kits are also contemplated.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: November 29, 2022
    Assignee: Genentech, Inc.
    Inventors: Ho Young Lee, Guoying Jiang, Pin Yee Wong, Kendall Carey
  • CELL-BASED ASSAY FOR DETECTING ANTl-CD3 HOMODIMERS
    Publication number: 20200378987
    Abstract: The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.
    Type: Application
    Filed: May 14, 2020
    Publication date: December 3, 2020
    Applicant: Genentech, Inc.
    Inventor: Kendall CAREY
  • Cell-based assay for detecting anti-CD3 homodimers
    Patent number: 10690678
    Abstract: The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: June 23, 2020
    Assignee: Genentech, Inc.
    Inventor: Kendall Carey
  • METHODS FOR ASSAYING T-CELL DEPENDENT BISPECIFIC ANTIBODIES
    Publication number: 20200182882
    Abstract: The present invention provides a cell-based assay for measuring T cell activation mediated by a T cell -dependent bispecific antibody (TDB). In some aspects, the assay is useful for detecting a TDB in a composition, quantitating the amount of TDB in a composition, determining the potency and/or specificity of a TDB, or determining if a population of cells expresses a target antigen. Compositions and kits are also contemplated.
    Type: Application
    Filed: January 25, 2017
    Publication date: June 11, 2020
    Inventors: Ho Young LEE, Guoying JIANG, Pin Yee WONG, Kendall CAREY
  • CELL-BASED ASSAY FOR DETECTING ANTI-CD3 HOMODIMERS
    Publication number: 20180267055
    Abstract: The present invention provides a cell-based assay for identifying and/or quantifying anti-CD3 homodimers in a composition comprising a T cell-dependent Bispecific antibody (TDB). In some aspects, the invention T cells comprising a T cell activation responsive reporter are contacted with the TDB to detect the presence of anti-CD3 homodimers. Compositions of reporter T cells and kits are also contemplated.
    Type: Application
    Filed: November 28, 2017
    Publication date: September 20, 2018
    Applicant: Genentech, Inc.
    Inventor: Kendall CAREY
  • Methods for processing coagulation factors
    Patent number: 9598687
    Abstract: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 21, 2017
    Assignee: MEDIMMUNE, LLC
    Inventors: Alan Hunter, Xiangyang Wang, Timothy Pabst, Michaela Wendeler, Jihong Wang, Kendall Carey, Robert Strouse, Johnson Varghese
  • METHODS FOR PROCESSING COAGULATION FACTORS
    Publication number: 20140303353
    Abstract: The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
    Type: Application
    Filed: August 31, 2012
    Publication date: October 9, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: Alan Hunter, Xiangyang Wang, Timothy Pabst, Michaela Wendeler, Jihong Wang, Kendall Carey, Robert Strouse, Johnson Varghese
  • Inhibiting HER2 shedding with matrix metalloprotease antagonists
    Publication number: 20060177448
    Abstract: The present application describes using antagonists of matrix metalloproteases (MMPs), especially of MMP-15, for inhibiting HER2 shedding.
    Type: Application
    Filed: February 9, 2006
    Publication date: August 10, 2006
    Applicant: Genentech, Inc.
    Inventors: Kendall Carey, Ralph Schwall, Mark Sliwkowski, Gail Schwall