Publication number: 20080234303
Abstract: The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, salt thereof, wherein R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Type:
Application
Filed:
December 20, 2006
Publication date:
September 25, 2008
Inventors:
Samit Bhattacharya, Michael Luzzio, Donn Wishka, Gonghua Pan, Arthur Brosius, Joel Arcari, James Southers, Kendra Nelson, Jun Xiao