Abstract: [Problem] A compound which is useful as a STING inhibitor is provided. [Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.

Abstract: A flow channel member includes a first flow channel member non-transmissive of ultraviolet light and absorbent of laser light, a second flow channel member non-transmissive of ultraviolet light and absorbent of laser light, the second flow channel member being stacked on the first flow channel member to define a flow channel for liquid to flow between the second flow channel member and the first flow channel member, and a third flow channel member transmissive of laser light, the third flow channel member being fixed to the first flow channel member and the second flow channel member in such a manner as to close a gap between the first flow channel member and the second flow channel member.

Abstract: A flow channel member includes a first flow channel member non-transmissive of ultraviolet light and absorbent of laser light, a second flow channel member non-transmissive of ultraviolet light and absorbent of laser light, the second flow channel member being stacked on the first flow channel member to define a flow channel for liquid to flow between the second flow channel member and the first flow channel member, and a third flow channel member transmissive of laser light, the third flow channel member being fixed to the first flow channel member and the second flow channel member in such a manner as to close a gap between the first flow channel member and the second flow channel member.

Abstract: A control system includes: an engine; a first hydraulic pump and a second hydraulic pump driven by the engine; a switching device provided in a flow path that connects the first hydraulic pump to the second hydraulic pump, and configured to perform switching between a merged state in which the flow path is opened and a separated state in which the flow path is closed; a first hydraulic actuator to which hydraulic fluid discharged from the first hydraulic pump is supplied in the separated state; a second hydraulic actuator to which hydraulic fluid discharged from the second hydraulic pump is supplied in the separated state; a determining unit configured to determine whether output of the engine is limited; and a merging-separating control unit configured to control the switching device so as to perform switching to the merged state when the determining unit determines that output of the engine is limited.

Abstract: An arithmetic processing device includes a coefficient memory storing coefficients of a Taylor series expansion of a trigonometric function, a multiply-add arithmetic unit, a first bypass path supplying an output of the multiply-add arithmetic unit to a register file, an OR circuit calculating OR of a sign bit of the output of the multiply-add arithmetic unit and a least significant bit of a second input, a first selector selecting either a first input y or a value “1.0” an EOR circuit calculating an EOR of a first bit of the second input and a sign bit of an output of the first selector, and a second bypass path supplying the least significant bit of the second input to a coefficient selector. The multiply-add arithmetic unit executes an auxiliary instruction repeatedly while modifying a coefficient index from a maximum value to a minimum value to calculate sin (x).

Abstract: An arithmetic unit includes a multiplier multiplying first and second inputs to output a multiplication result, an adder adding the third input to the multiplication result to output a multiplication addition result, a normalization shift circuit shifting the multiplication addition result left with a left shift amount, and a left shift amount prediction circuit. The adder includes a carry-save adder adding a first addition value and a first carry value to the third input and a full adder outputting the multiplication addition result. The left shift amount prediction circuit includes a leading zero count circuit generating a leading zero count, a leading one count circuit generating a leading one count, and a correction circuit correcting the leading one count to zero when NOR of respective least significant bits of the M upper order bits of the second addition value and the second carry value of the full adder is true.

Abstract: A processor includes a cache memory, an issuing unit that issues, with respect to all element data as a processing object of a load instruction, a cache request to the cache memory for each of a plurality of groups which are divided to include element data, a comparing unit that compares addresses of the element data as the processing object of the load instruction, and determines whether element data in a same group are simultaneously accessible, and a control unit that accesses the cache memory according to the cache request registered in a load queue registering one or more cache requests issued from the issuing unit. The control unit processes by one access whole element data determined to be simultaneously accessible by the comparing unit.

Abstract: A preprocessing kit includes a separation device, a collecting container, and a skirt part. The skirt part is integrated with the separation device, and is provided to surround an outer circumferential surface of the separation device with a clearance being left from the outer circumferential surface so that a space having a closed upper side and an open lower side is formed between the outer circumferential surface of the separation device and the skirt part. The skirt part is provided in such a way that a lower end of the skirt part comes into intimate contact with a peripheral surface of an opening of the recess part when the collecting container containing the lower end of the separation device is fitted into the recess part.

Abstract: An arithmetic processing device includes a coefficient memory storing coefficients of a Taylor series expansion of a trigonometric function, a multiply-add arithmetic unit, a first bypass path supplying an output of the multiply-add arithmetic unit to a register file, an OR circuit calculating OR of a sign bit of the output of the multiply-add arithmetic unit and a least significant bit of a second input, a first selector selecting either a first input y or a value “1.0” an EOR circuit calculating an EOR of a first bit of the second input and a sign bit of an output of the first selector, and a second bypass path supplying the least significant bit of the second input to a coefficient selector. The multiply-add arithmetic unit executes an auxiliary instruction repeatedly while modifying a coefficient index from a maximum value to a minimum value to calculate sin (x).

Abstract: A control system includes: an engine; a first hydraulic pump and a second hydraulic pump driven by the engine; a switching device provided in a flow path that connects the first hydraulic pump to the second hydraulic pump, and configured to perform switching between a merged state in which the flow path is opened and a separated state in which the flow path is closed; a first hydraulic actuator to which hydraulic fluid discharged from the first hydraulic pump is supplied in the separated state; a second hydraulic actuator to which hydraulic fluid discharged from the second hydraulic pump is supplied in the separated state; a determining unit configured to determine whether output of the engine is limited; and a merging-separating control unit configured to control the switching device so as to perform switching to the merged state when the determining unit determines that output of the engine is limited.

Abstract: An arithmetic unit includes a multiplier multiplying first and second inputs to output a multiplication result, an adder adding the third input to the multiplication result to output a multiplication addition result, a normalization shift circuit shifting the multiplication addition result left with a left shift amount, and a left shift amount prediction circuit. The adder includes a carry-save adder adding a first addition value and a first carry value to the third input and a full adder outputting the multiplication addition result. The left shift amount prediction circuit includes a leading zero count circuit generating a leading zero count, a leading one count circuit generating a leading one count, and a correction circuit correcting the leading one count to zero when NOR of respective least significant bits of the M upper order bits of the second addition value and the second carry value of the full adder is true.

Abstract: A processing device includes an instruction control unit configured to issue an instruction, an operation unit configured to perform a floating-point operation in accordance with an instruction issued from the instruction control unit, a detection unit configured to detect a subnormal number from data related to the floating-point operation performed in the operation unit, and a processing unit configured to process the data in a case in which a subnormal number is included in the data. When committing the instruction, in a case in which a subnormal number was detected by the detection unit from the data related to the floating-point operation performed in accordance with the instruction, the instruction control unit transits to a subnormal processing mode for processing a subnormal number, instructs the operation unit to re-execute the instruction, and instructs the processing unit to process the detected subnormal number.

Abstract: A flow-path structure configures an internal flow path for supply a liquid to a nozzle which ejects the liquid, and the flow-path structure includes a filter disposed across the internal flow path; a defoaming space that communicates with a defoaming route through which gases are discharged; and a first gas permeable membrane that is interposed between the defoaming space and a storage space positioned on a downstream side from the filter.

Abstract: A preprocessing kit includes a separation device, a collecting container, and a skirt part. The skirt part is integrated with the separation device, and is provided to surround an outer circumferential surface of the separation device with a clearance being left from the outer circumferential surface so that a space having a closed upper side and an open lower side is formed between the outer circumferential surface of the separation device and the skirt part. The skirt part is provided in such a way that a lower end of the skirt part comes into intimate contact with a peripheral surface of an opening of the recess part when the collecting container containing the lower end of the separation device is fitted into the recess part.

Abstract: A hybrid hydraulic excavator includes an engine, a generator motor, a capacitor, a cooling system being configured to cool the capacitor, and a controller. The cooling system includes a circulation mechanism being configured to circulate a cooling water, and a cooler being configured to cool the cooling water with output from the engine. The controller prohibits auto-stop of the engine when it is determined that the capacitor is overheated.

Abstract: A processor includes a cache memory, an issuing unit that issues, with respect to all element data as a processing object of a load instruction, a cache request to the cache memory for each of a plurality of groups which are divided to include element data, a comparing unit that compares addresses of the element data as the processing object of the load instruction, and determines whether element data in a same group are simultaneously accessible, and a control unit that accesses the cache memory according to the cache request registered in a load queue registering one or more cache requests issued from the issuing unit. The control unit processes by one access whole element data determined to be simultaneously accessible by the comparing unit.

Abstract: A hybrid hydraulic excavator includes: an engine; a generator motor; an electric storage device; a commanding system being configured to command at least activation of a service mode for maintenance and execution of a charge-release process for the electric storage device; a display being configured to provide at least information on the charge-release process for the electric storage device; and a display controller being configured to control displaying of the display. The display controller commands the display to display charge-release-failure information when the charge-release process is ongoing at the elapse of a predetermined duration of time since the activation of the service mode was commanded.

Abstract: A processor for dividing by calculating repeatedly an n-bit width partial quotient includes, a dividend zero count value counter that counts a dividend zero count value, a divisor zero count value counter that counts a divisor zero count value, a correction value calculator that calculates a correction value to a loop count value, a correction loop count value calculator that calculates a correction loop count value, a dividend shift unit that shifts leftward an absolute value of the dividend by the dividend zero count value and shifts rightward the leftward-shifted absolute value of the dividend by the correction value, a divisor shift unit that shifts leftward an absolute value of the divisor by the divisor zero count value, and a division loop operation unit that divides based on an output value from the dividend shift unit, an output value from the divisor shift unit, and the correction loop count value.

Abstract: A hybrid hydraulic excavator includes: an engine; a generator motor; an electric storage device; a commanding system being configured to command at least activation of a service mode for maintenance and execution of a charge-release process for the electric storage device; a display being configured to provide at least information on the charge-release process for the electric storage device; and a display controller being configured to control displaying of the display. The display controller commands the display to display charge-release-failure information when the charge-release process is ongoing at the elapse of a predetermined duration of time since the activation of the service mode was commanded.

Abstract: A new and distinct cultivar of Mandevilla plant named ‘Sunparakitaho’, characterized by its upright and vining plant habit; vigorous growth habit; freely branching habit, dense and bushy plant form; glossy dark green-colored leaves; freely flowering habit; long flowering period; and medium-sized flowers with pale pink-colored flowers with yellow orange-colored throats.