Abstract: The invention relates to a bolt for integrally fastening a first member and a second member, which are spaced away to each other, the bolt comprising a cylindrical-shaped collar bolt provided on a portion of an outer peripheral surface thereof with an external thread portion and on an inner peripheral surface thereof with an internal thread portion; and a bolt body having in an area of one end of a shank an external thread portion capable of threading into the internal thread portion of the collar bolt and a head on the other end thereof.

Abstract: An L-methionine &ggr;-lyase having modified function which is obtained by structurally stabilizing natural L-methionine &ggr;-lyase by analyzing the structure of crystals thereof by using X-ray, estimating an amino acid sequence concerning its substrate specificity and varying amino acid residue thereof; enzymes comprising a protein constituting the L-methionine &ggr;-lyase having modified function or its multimer (preferably its tetramer); DNA sequences encoding these enzymes; a process for producing these enzymes; and medicinal preparations (preferably anticancer agent) containing these enzymes.

Abstract: The present invention provides a novel L-glutamate oxidase, a gene encoding the enzyme, and a method for producing the enzyme. By use of a gene encoding the enzyme, L-glutamate oxidase can be readily prepared at low costs through a recombinant DNA technique.

Abstract: A tooth coating composition comprises a component A including a reactive metallic oxide; and a component B of water, which are mixed with each other when using the tooth coating composition, wherein at least one of the component A and the component B comprises a polycarboxylic acids, a reaction retarder and a coating film-softening agent. Specifically, the reactive metallic oxide may be zinc oxide or the like, the polycarboxylic acid may be polyacrylic acid or the like, the reaction retarder may be calcium hydrogen phosphate or the like, and the coating film-softening agent may be polymethyl methacrylate or the like. The coated film formed from the tooth coating composition has a color approximate to the color of natural teeth, and causes little irritation to mouths. In addition, the coating film has high durability and easy removability after use, so that it can be easily used by ordinary consumers.

Abstract: A tooth coating composition contains shellac, solvent for the shellac, and mica titanium as the main constituents. The coating provided on teeth with such composition is excellent in its drying property, durability, color tone, and easiness of removal thereof. The content of the shellac in the whole composition is preferably from 6 to 12% by weight and the content of the mica titanium is preferably from 3.5 to 16% by weight.

Abstract: The invention relates to a bolt for integrally fastening a first member and a second member, which are spaced away to each other, the bolt comprising a cylindrical-shaped collar bolt provided on a portion of an outer peripheral surface thereof with an external thread portion and on an inner peripheral surface thereof with an internal thread portion; and a bolt body having in an area of one end of a shank an external thread portion capable of threading into the internal thread portion of the collar bolt and a head on the other end thereof.

Abstract: A tooth coating composition comprises a component A including a reactive metallic oxide; and a component B of water, which are mixed with each other when using the tooth coating composition, wherein at least one of the component A and the component B comprises a polycarboxylic acids, a reaction retarder and a coating film-softening agent. Specifically, the reactive metallic oxide may be zinc oxide or the like, the polycarboxylic acid may be polyacrylic acid or the like, the reaction retarder may be calcium hydrogen phosphate or the like, and the coating film-softening agent may be polymethyl methacrylate or the like. The coated film formed from the tooth coating composition has a color approximate to the color of natural teeth, and causes little irritation to mouths. In addition, the coating film has high durability and easy removability after use, so that it can be easily used by ordinary consumers.

Abstract: The present invention provides a low irritant adhesive pad which can retain its adhesion for a repeated use, and a process for its production. The adhesive pad 1 of the invention is used as stuck on the human body and comprises a pad body 2 made of a silicone rubber, and a silicone gel adhesive layer 3 integrally formed on the pad body to provide an adhesive surface.

Abstract: A recombinant protein capable of constituting a recombinant L-methionine .gamma.-lyase or a variant thereof, a recombinant oligomeric enzyme, preferably tetrameric enzyme, consisting of the recombinant protein, a DNA molecule encoding the same, an expression vector containing the DNA molecule, a host cell harboring the expression vector, a method of preparing the recombinant L-methionine .gamma.-lyase, and anti-tumor agent comprising the recombinant L-methionine .gamma.-lyase or a variant thereof are provided.

Abstract: A recombinant protein capable of constituting a recombinant L-methionine .gamma.-lyase or a variant thereof, a recombinant oligomeric enzyme, preferably tetrameric enzyme, consisting of the recombinant protein, a DNA molecule encoding the same, an expression vector containing the DNA molecule, a host cell harboring the expression vector, a method of preparing the recombinant L-methionine .gamma.-lyase, and anti-tumor agent comprising the recombinant L-methionine .gamma.-lyase or a variant thereof are provided.

Abstract: A cushioning structure which is a three-dimensional multiple woven texture formed of a surface layer portion and an intermediate layer portion, characterized in that (i) protuberances are formed on one side or both sides of the surface layer portion at least unidirectionally and have an average height of 2 to 15 mm, an average width of one side of the protuberance being 2 to 30 mm; and that (ii) said intermediate layer portion is formed of one layer or by laminating two or more layers, said layer having a plurality of communicating hollow portions which are arranged in parallel unidirectionally. This cushioning structure is excellent in air permeability, cushioning properties, durability and washability, and is therefore useful as various cushioning materials.

Abstract: A method of producing a spiral electrode group comprising a step for preparing a beltlike positive electrode plate whose thickness and width PT are PW respectively, a beltlike negative electrode plate whose thickness and width are NT and NW respectively, a beltlike first separator whose width is longer than PW+2PT, and a beltlike second separator whose width is longer than NW+2NT; a second step of making a set of the first separator and the positive electrode plate by putting a central part of the first separator and a surface of the positive electrode plate together, and by putting each horizontal end of the first separator and each side surface of the positive electrode plate together; a third step of making a set of the second separator and the negative electrode plate by putting a central part of the second separator and a surface of the negative electrode plate together, and by putting each horizontal end of the second separator and each side surface of the negative electrode plate together; and a fourth

Abstract: A blood-treating system in which apparatus for the purification of blood by purifying the blood plasma. The system includes as principal elements, an apparatus for separating blood plasma by way of a membrane, an apparatus for purifying blood plasma and an apparatus for mixing blood with blood plasma to be placed between a blood-introducing portion and a purified blood-withdrawing portion of the system. This system can remove useless substances from blood with a high efficiency without damaging and reducing blood cell components or any fear of mixing of the fine powder in the purifying agent.

Abstract: A blood-treating system in which apparatus for the purification of blood by purifying blood plasma, is provided. The system includes as principal elements, an apparatus for separating blood plasma by way of a membrane, an apparatus for purifying blood plasma and an apparatus for mixing blood with blood plasma to be placed between a blood-introducing portion and a purified blood-withdrawing portion of the system. This system can remove useless substances from blood with a high efficiency without damaging and reducing blood cell components or any fear of mixing of the fine powder in the purifying agent.

Abstract: Cis-platinum (II) complexes of 1,2-diaminocyclohexanes, more particularly, cis-platinum (II) complexes represented by the general formula ##STR1## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans-d- or trans-l-; and R.sup.1 and R.sup.2, which are same, each represent a halogen atom, or R.sup.1 and R.sup.2, when taken together, represent a group represented by the formula ##STR2## wherein R.sup.3 represents a >CH.sub.2 group, a >CHCH.sub.3 or >CHCH.sub.2 CH.sub.3 group are disclosed. Further complexes of uracil and cis-[platinum(II)-cis-, trans-d or trans-l- 1,2-diaminocyclohexane] are disclosed. These complexes have anti-tumor activity in mice. Cis-platinum (II) complex of cis-1,2-diaminocyclohexane is most effective.

Abstract: An apparatus for treating ascites which is safe and superior in performance and does not cause hemolysis, by removing harmful bacteria or cancer cells contained in ascites, by filtration, concentrating useful proteins, etc. contained therein and returning the resulting concentrate to living body is provided.Said apparatus comprises an ascites-transporting means, a hemolysis-preventive means connected to said ascites-transporting means, a filter for removing bacteria and cancer cells, containing at least one membrane for filtering the ascites which has passed said hemolysis-preventive means, and a concentrating vessel containing at least one membrane for concentrating the ascites thus filtered.

Abstract: A dialysis unit and a dialysis apparatus employing the dialysis unit which can perform dialysis at a very high efficiency. The unit comprises a vast plurality of semi-permeable hollow fibers substantially equal in length, which fibers are gathered to form a bundle and bonded in liquid-tight connection at both ends portions thereof. This bundle of hollow fibers is loosely encased in a casing having a plurality of openings substantially uniformly distributed all over the casing. The dialysis unit is put in a dialyzate bath having therein a means for making a forced current of the dialyzate. The dialyzate flows into the casing through the openings and acts upon the bundle of hollow fibers from all directions. Accordingly, the dialyzate can flow freely inside and outside the bundle, while maintaining good contact between the dialyzate and the surfaces of the fibers, even in the inner portion of the bundle.

Abstract: A two step type pressurized injector comprising as main parts, a medicine chamber for holding an injecting liquid, a piston for pressurizing the injecting liquid, a nozzle hole for ejecting the injecting liquid, a power means for displacing said piston and a regulating means for regulating the displacement of said piston is provided. This injector gives less irritation i.e. pain to the skin of a person who is receiving the injection and less external injury to the skin. The injection is carried out under a pressure of 120 Kg/cm.sup.2 or higher to effect rapid perforation to a skin and then under a pressure of 100 Kg/cm.sup.2 or lower after the perforation.

Abstract: A liquid treatment apparatus which can perform dialysis at a very high efficiency and which is suitable for dialysis of human blood is provided. The apparatus comprises a bundle of a vast plurality of semi-permeable hollow fibers substantially equal in length, which is gathered and bonded only at both end portions thereof. An inside liquid is permitted to flow the interior of the individual hollow fibers. This bundle of hollow fibers is loosely suspended in a vessel having a substantially U-shaped passage for an outside liquid, and the two gathered and bonded portions of the fiber bundle are connected to the vessel at two spaced-apart openings formed on the top face of the vessel. A dialyzate flowing outside the hollow fibers is introduced from an introduction opening formed in the bottom face of the vessel.